Redesign of allosteric regulation of enzyme for self-regulated dynamic control of metabolic fluxes in microbial amino acid production

• Applicant: Professor Dr. An-Ping Zeng
• Subject Area: Biological Process Engineering ; Pharmacy
• Term: from 2011 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 203132763

• Final Report Year: 2017

No abstract available

Publications

• (2015) Rational design of allosteric regulation of homoserine dehydrogenase by a non-natural inhibitor L-lysine. ACS Synthetic Biology. 4(2):126-131
  Chen, Zhen; Rappert, Sugima & Zeng, An-Ping
  
• (2016) Protein engineering approaches to chemical biotechnology. Current Opinion in Biotechnology. 42: 198–205
  Chen, Zhen & Zeng, An-Ping
  
• (2017) Analysis of intracellular metabolites of Corynebacterium glutamicum at high cell density with automated sampling and filtration and assessment of engineered enzymes for effective l-lysine production. Engineering in life sciences 17 (5) 512–522
  da Luz, Julian A.; Hans, Enrico; Frank, Doinita & Zeng, An‐Ping
  
• (2018) Engineering Biomolecular Switches for Dynamic Metabolic Control. In: A.-P. Zeng, H. Zhao (eds.) Synthetic Biology and Metabolic Engineering. Adv. Biochem. Eng. /Biotechnol., vol. 162. S. 45–76
  Ma, Cheng-Wei; Zhou, Li-Bang & Zeng, An-Ping