Redesign of allosteric regulation of enzyme for self-regulated dynamic control of metabolic fluxes in microbial amino acid production

Applicant Professor Dr. An-Ping Zeng

Subject Area Biological Process Engineering
Pharmacy

Term from 2011 to 2016

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 203132763

Final Report Year 2017

Final Report Abstract

No abstract available

(2017) Analysis of intracellular metabolites of Corynebacterium glutamicum at high cell density with automated sampling and filtration and assessment of engineered enzymes for effective l-lysine production. Engineering in life sciences 17 (5) 512–522
Da Luz, Julian A.; Hans, Enrico; Frank, Doinita; Zeng, An-Ping
(See online at https://doi.org/10.1002/elsc.201600163)
(2015) Rational design of allosteric regulation of homoserine dehydrogenase by a non-natural inhibitor L-lysine. ACS Synthetic Biology. 4(2):126-131
Z. Chen, S. Rappert and A.-P. Zeng
(See online at https://doi.org/10.1021/sb400133g)
(2016) Protein engineering approaches to chemical biotechnology. Current Opinion in Biotechnology. 42: 198–205
Z. Chen and A.-P. Zeng
(See online at https://doi.org/10.1016/j.copbio.2016.07.007)
(2018) Engineering Biomolecular Switches for Dynamic Metabolic Control. In: A.-P. Zeng, H. Zhao (eds.) Synthetic Biology and Metabolic Engineering. Adv. Biochem. Eng. /Biotechnol., vol. 162. S. 45–76
C.-W. Ma, L.–B. Zhou and A.-P. Zeng
(See online at https://doi.org/10.1007/10_2016_9)