Central Project 2 - Central Recruitment and Assessment
Final Report Abstract
The Recruitment and Assessment Center (RAC) centrally recruited participants for all projects and monitored data for all projects at a central database. Data from all individual projects were made available to be used for post-hoc analyses by all projects. In the first funding period, participants with current Borderline Personality Disorder (BPD), remitted BPD, Posttraumatic Stress Disorder (PTSD) and healthy control participants were recruited. In the second funding period, recruitment was re-stricted to current BPD and healthy controls. Interested persons were called by one of the diagnosticians and the BPD-section of the IPDE and the PTSD-section of the SCID-I was administered. Suitable participants were finally invited for taking part in the studies. Later, a pre-screening was introduced, during which a study nurse checked the general exclusion criteria such as medication, pregnancy or underweight. Due to the prescreening, a significant amount of diagnosticians` time could be saved because medication was the main reason for excluding participants at this stage. One of the advantages of the Central Project was the overview of the different studies with their individual needs so that synergies could be detected. The Central Project also mediated between the interests of the individual projects and the burden of the participants. The professionalization of the process and specialization of team members for different parts (arrival, schedule, personal support, diagnostic assessments) along with a personal assistance of a student research assistants for the participants led to a high satisfaction of the participants. The multiple steps of the recruitment process in combination with rater trainings and weekly supervisions led to a highly accurately diagnosed sample of 413 (remitted) Borderline and 37 PTSD patients. During both funding periods, inter-rater reliabilities in the sample as assessed by intra-class coefficients were consistently larger than 0.9 In 2014, the so far recruited patients were genotyped for ~100 selected single-nucleotide polymorphisms (SNPs) using the iPLEX assay on the MassARRAY MALDI-TOF mass spectrometer (SE-QUE-NOM, San Diego, California, USA) within the context of a larger study. In single SNP analyses there was found (i) an association between dopa decarboxylase gene variants and borderline personality disorder and (ii) a nominally significant association of a SNP in the bipolar disorder gene CACNA1C in women. 71 BPD patients were genotyped using the Infinium PsychArray-24 Bead Chip (Illumina, San Diego, CA, USA). Remaining BPD patients will be genotyped on the Global Screening Array Bead Chip (Il-lumina, San Diego, CA, USA). KFO256 patients were part of the first genome-wide association study in BPD cases and controls. In a gene-based analysis, two significant genes were found. Moreover, a genetic overlap with bipolar disorder, major depression and schizophrenia could be shown.
Publications
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(2014). Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder. Psychiatric Genetics, 24(6), 262-265
Witt, S. H., Kleindienst, N., Frank, J., Treutlein, J., Mühleisen, T., Degenhardt, F., . . . Bohus, M.
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(2014). Association between dopa decarboxylase gene variants and borderline personality disorder. Psychiatry Research, 219(3), 693-695
Mobascher, A., Bohus, M., Dahmen, N., Dietl, L., Giegling, I., Jungkunz, M., . . . Lieb, K.
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(2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry, 7, e1155
Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., . . . Rietschel, M.
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How to Assess Recovery in Borderline Personality Disorder: Psychosocial Functioning and Satisfaction With Life in a Sample of Former DBT Study Patients. J Pers Disord. 2018 Sep 4:1-19
Zeitler, ML., Bohus, M., Kleindienst, N., Knies, R., Ostermann, M., Schmahl, C., and Lyssenko, L.
