Characterizing and modulating thalamo-pontine networks in headache (A05)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

The goal of this project is to investigate nociceptive processing focusing on the hierarchical role and structure of brainstem networks in different headache and facial pain syndromes and between the ictal and interictal state building on the results of the previous funding period. Hypothesis-driven experiments will focus on hypothalamic input to lower brainstem nuclei such as the PAG, SSR and trigeminal nuclei. We will subsequently describe cortico-pontine networks using simultaneous brainstem functional MRI and EEG in migraine patients. Finally, we will investigate brainstem networks mediating the trigemino-autonomic reflex and modulate this reflex arc using highly specific interventions such as oxygen inhalation and indomethacin.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Arne May