Structural determinants of disturbed evidence accumulation in cortical decision networks after stroke (C02)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

The evidence accumulation process during decision making is distributed over a large-scale structural and functional network of cortical regions. However, fundamental questions concerning the organization and structural determinants of this network remain open. We will study stroke patients and patients with cerebral small vessel disease, providing models for focal and distributed brain lesions, by algorithmic modeling of behavior, structural MRI, EEG, and catecholaminergic pharmacologic intervention. By this, we aim at a better understanding of the structural underpinnings and organization of the cortical decision network in the healthy brain, and of cognitive impairments in patients with vascular brain lesions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Heads: Privatdozent Dr. Bastian Cheng, since 7/2019; Professor Dr. Jens Fiehler, until 6/2019; Professor Dr. Götz Thomalla