Modellierung der Nukleinsäuren-Packung in Virushüllen und Selbstorganisation von Viruskapsiden

• Antragsteller: Dr. Andrey Georgievich Cherstvy, Ph.D.
• Fachliche Zuordnung: Biophysik
• Förderung: Förderung von 2012 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 210890642

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

The current project has been focused on understanding of nucleic acid packing inside virus capsids and kinetics of virus self‐assembly. The major focus was on (i) implications of intermolecular interactions between the DNA under confinement, (ii) the adsorption and charge matching of flexible RNA chains during virus self‐assembly, (iii) the effects of macromolecular crowding in the cell cytoplasm on the reaction kinetics and diffusion of various molecular components. A significant progress was achieved in each of these key directions, as recognized by the publication record in solid scientific journals and the overall PI’s output.

Projektbezogene Publikationen (Auswahl)

• “Electrostatic interactions in biological DNA‐related systems“, Phys. Chem. Chem. Phys., 13 9942 (2011)
  A. G. Cherstvy
  
• “Critical polyelectrolyte adsorption under confinement: planar slit, cylindrical pore, and spherical cavity”, Biopolymers, 97 311 (2012)
  A. G. Cherstvy
  (Siehe online unter https://doi.org/10.1002/bip.22023)
• “Anomalous diffusion and ergodicity breaking in heterogeneous diffusion processes”, New J. Phys., 15 083039 (2013)
  A. G. Cherstvy, A. V. Chechkin, and R. Metzler
  (Siehe online unter https://doi.org/10.1088/1367-2630/15/8/083039)
• “Sensing viruses by mechanical tension of DNA in responsive hydrogels”, Phys Rev. X, 4 021002 (2014)
  J. Shin, A. G. Cherstvy, and R. Metzler
  (Siehe online unter https://doi.org/10.1103/PhysRevX.4.021002)
• “Strong and weak polyelectrolyte adsorption onto oppositely charged curved surfaces”, Adv. Polym. Sci., 255 1 (2014)
  R. G. Winkler and A. G. Cherstvy
  (Siehe online unter https://doi.org/10.1007/12_2012_183)
• “Polymer Looping Is Controlled by Macromolecular Crowding, Spatial Confinement, and Chain Stiffness”, ACS Macro Lett., 4 202‐206 (2015)
  J. Shin, A. G. Cherstvy, and R. Metzler
  (Siehe online unter https://doi.org/10.1021/mz500709w)