Innate immune response in virus-induced liver damage (A10)

• Subject Area: Immunology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431

In unpublished preliminary work we found that T cells are responsible for induction of apoptotic liver cells after LCMV infection. The presence of apoptotic cells correlated with the induction of the inhibiting cytokine IL-10. In the following funding period, the influence of apoptotic cells on the antiviral immune response will be determined. The role of apoptotic cells on liver cell damage and liver regeneration will be investigated. Mechanistically, we will focus on the interaction of MHC-I with inhibitory receptors, the tyrosine kinase MER (Mertk) and the "do not eat me" signal CD47.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 974: Communication and System Relevance in Liver Injury and Regeneration
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Heads: Professor Dr. Karl Sebastian Lang; Professor Dr. Philipp Alexander Lang, Ph.D.