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Structural models and conformational dynamics of the G protein coupled bile acid receptor TGR5 (B02)

Subject Area Structural Biology
Term from 2012 to 2016
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431
 
The project focuses on the structural investigation of signaling properties of the bile acid G-protein coupled receptor TGR5 as well as the structure-based development of small molecule modulators/ inhibitors of TGR5 signaling. Using the binding model of TGR5-agonists, TGR5-antagonist will be identified using a computer-based approach, further characterized in vitro using NMR and fluorescence-spectroscopy and validated using ex vivo functional studies. In addition, a novel approach to modulate the TGR5/ G-protein interaction by small molecule inhibitors will be pursued.
DFG Programme Collaborative Research Centres
 
 

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