Molekulare Mechanismen der Leukozytenaktivierung und -rekrutierung im Rahmen systemischer Inflammationssyndrome (SIRS und Sepsis)

• Antragsteller: Professor Dr. Alexander Zarbock
• Fachliche Zuordnung: Anästhesiologie
• Förderung: Förderung von 2011 bis 2017
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 211933074

• Erstellungsjahr: 2017

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. Journal of Experimental Medicine, Vol. 209. 2012, pp. 407-21.
  Block, Helena; Herter, Jan M.; Rossaint, Jan; Stadtmann, Anika; Kliche, Stefanie; Lowell, Clifford A. & Zarbock, Alexander
  
• The PSGL-1-Lselectin signaling complex regulates neutrophil adhesion under flow. Journal of Experimental Medicine, Vol. 210. 2013, No. 11, 2171-2180.
  Stadtmann, Anika; Germena, Giulia; Block, Helena; Boras, Mark; Rossaint, Jan; Sundd, Prithu; Lefort, Craig; Fisher, Charles I.; Buscher, Konrad; Gelschefarth, Bernadette; Urzainqui, Ana; Gerke, Volker; Ley, Klaus & Zarbock, Alexander
  
• Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. Journal of the American Medical Association, Vol. 313. 2015, Issue 21, pp. 2133-2141.
  Zarbock, Alexander; Schmidt, Christoph; Van Aken, Hugo; Wempe, Carola; Martens, Sven; Zahn, Peter K.; Wolf, Britta; Goebel, Ulrich; Schwer, Christian I.; Rosenberger, Peter; Haeberle, Helene; Görlich, Dennis; Kellum, John A. & Meersch, Melanie
  
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nature Communications, Vol. 7. 2016, Article number: 13464.
  Rossaint, Jan; Kühne, Katharina; Skupski, Jennifer; Van Aken, Hugo; Looney, Mark R.; Hidalgo, Andres & Zarbock, Alexander
  
• FGF23 signaling impairs neutrophil recruitment and host defense during CKD. Journal of Clinical Investigation, Vol. 126. 2016, Issue 3, pp. 962-974.
  Rossaint, Jan; Oehmichen, Jessica; Van Aken, Hugo; Reuter, Stefan; Pavenstädt, Hermann J.; Meersch, Melanie; Unruh, Mark & Zarbock, Alexander
  
• Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Medicine, Vol. 43. 2017, Issue 11, pp. 1551–1561.
  Meersch, Melanie; Schmidt, Christoph; Hoffmeier, Andreas; Van Aken, Hugo; Wempe, Carola; Gerss, Joachim & Zarbock, Alexander
  
• Skap2 is required for β2 integrinmediated neutrophil recruitment and functions. Journal of Experimental Medicine, Vol. 214. 2017, no. 3, pp. 851-874.
  Boras, Mark; Volmering, Stephanie; Bokemeyer, Arne; Rossaint, Jan; Block, Helena; Bardel, Bernadette; Van Marck, Veerle; Heitplatz, Barbara; Kliche, Stefanie; Reinhold, Annegret; Lowell, Clifford & Zarbock, Alexander