Molecular mechanisms of leukocyte activation and recruitment during systemic inflammatory responses (SIRS and sepsis)

• Applicant: Professor Dr. Alexander Zarbock
• Subject Area: Anaesthesiology
• Term: from 2011 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 211933074

• Final Report Year: 2017

Final Report Abstract

No abstract available

Publications

• Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. Journal of Experimental Medicine, Vol. 209. 2012, pp. 407-21.
  Block H., Herter J.M., Rossaint J., Stadtmann A., Kliche S., Lowell C.A., Zarbock A.
  (See online at https://doi.org/10.1084/jem.20111493)
• The PSGL-1-Lselectin signaling complex regulates neutrophil adhesion under flow. Journal of Experimental Medicine, Vol. 210. 2013, No. 11, 2171-2180.
  Stadtmann A., Germena G., Block H., Boras M., Rossaint J., Sundd P., Lefort C., Fisher C.I., Buscher K., Gelschefarth B., Urzainqui A., Gerke V., Ley K., Zarbock A.
  (See online at https://doi.org/10.1084/jem.20130664)
• Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. Journal of the American Medical Association, Vol. 313. 2015, Issue 21, pp. 2133-2141.
  Zarbock A., Schmidt C., Van Aken H., et al.
  (See online at https://doi.org/10.1001/jama.2015.4189)
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nature Communications, Vol. 7. 2016, Article number: 13464.
  Rossaint J., Kühne K., Skupski J., Van Aken H., Looney M.R., Hidalgo A., Zarbock A.
  (See online at https://doi.org/10.1038/ncomms13464)
• FGF23 signaling impairs neutrophil recruitment and host defense during CKD. Journal of Clinical Investigation, Vol. 126. 2016, Issue 3, pp. 962-974.
  Zarbock A.
  (See online at https://doi.org/10.1172/JCI83470)
• Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Medicine, Vol. 43. 2017, Issue 11, pp. 1551–1561.
  Meersch M., Schmidt C., Hoffmeier A., Van Aken H., Wempe C., Gerss J., Zarbock A.
  (See online at https://doi.org/10.1007/s00134-016-4670-3)
• Skap2 is required for β2 integrinmediated neutrophil recruitment and functions. Journal of Experimental Medicine, Vol. 214. 2017, no. 3, pp. 851-874.
  Boras M., Volmering S., Bokemeyer A., Rossaint J., Block H., Bardel B., Van Marck V., Heitplatz B., Kliche S., Reinhold A., Lowell C., Zarbock A.
  (See online at https://doi.org/10.1084/jem.20160647)