GRK 1870:  Bacterial Respiratory Infections - Common and Specific Mechanism of Pathogen Adaption and Immune Defence

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 214214857

• Final Report Year: 2020

Final Report Abstract

The objective of the RTG 1870 BacRes was to form a generation of scientists in infection research associated with the development of competencies in bioanalytics and methodologies of infection biology and infection immunology as well. The PhD students were embedded in a cutting-edge scientific research environment and worked in interdisciplinary research teams together with a network of international partners. The structured qualification programme and PhD student training in methodologies as well as project management were tailore-made so that the PhD students developed critical thinking as well as communication and problem solving skills. In this respect, it was highly important to offer flexible professional skill training with a number of optional workshops. This enabled the PhD students to develop their individual career plan with the support of the supervisor or personal Thesis Committee. The concept of the supervision strategy and mentoring by a personal Thesis Committee in combination with the annual reports had been highly successful to develop and focus the research projects of the PhD students. Importantly, this resulted in a number of joined publications and outstanding results. Both, the PhD students and the supervisors independently participated at courses of good scientific practice. This facilitated the communication between the supervisor and PhD student and also provided the know-how for communication, project management, and leadership. The optional international mobility programme between the international partners and the dual doctoral programme (Greifswald – Groningen) promoted interdisciplinary work on doctoral projects and enabled the transfer of know-how and technologies and resulted in joint publications. The RTG 1870 Retreats jointly organized with the International Leibniz Research School in Jena (spokesperson Prof. Peter F. Zipfel) or the RTG 1409 of the University of Münster (spokesperson Prof. M. Alexander Schmidt) were extremely successful, opened the view for related scientific approaches. In conclusion, the PhD students benefitted in the RTG 1870 from a highly interdisciplinary and collaborative research programme, the national and international conferences e.g., 1st International Conference on Respiratory Pathogens organised by the RTG BacRes, and the structured qualification programme. The scientific, methodological and complementary skills acquired in the RTG 1870 strengthened the key competencies of the PhD students and offered excellent perspectives for successful career of the doctoral researchers in science or industry.

Publications

• (2014) Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus. Mol Microbiol 93(6):1259-68
  Müller M, Reiß S, Schlüter R, Mäder U, Beyer A, Reiß W, Marles-Wright J, Lewis RJ, Pförtner H, Völker U, Riedel K, Hecker M, Engelmann S, Pané-Farré J
  (See online at https://doi.org/10.1111/mmi.12733)
• (2014) Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus. Mol Microbiol 93(6):1259-68
  Müller M, Reiß S, Schlüter R, Mäder U, Beyer A, Reiß W, Marles-Wright J, Lewis RJ, Pförtner H, Völker U, Riedel K, Hecker M, Engelmann S, Pané-Farré J
  (See online at https://doi.org/10.1111/mmi.12733)
• (2014) Impact of antibiotics with various target sides on the metabolome of Staphylococcus aureus. Antimicrob Agents Chemother 58(12):7151- 7163
  Dörries K, Schlueter R, Lalk M
  (See online at https://doi.org/10.1128/aac.03104-14)
• (2014) Metabolic insights into Staphylococcus aureus and its natural habitats. Dissertation, University of Greifswald
  Dörries K
  
• (2014) Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae. MBio 5(6)
  Schulz C, Gierok P, Petruschka L, Lalk M, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/mbio.01858-14)
• (2014) Regulation of the Arginine Deiminase System by ArgR2 Interferes with Arginine Metabolism and Fitness of Streptococcus pneumoniae. MBio 5(6)
  Schulz C, Gierok P, Petruschka L, Lalk M, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/mbio.01858-14)
• (2014) Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB. Mol Microbiol 93(6):1183-206
  Abdullah MR, Gutiérrez-Fernández J, Pribyl T, Gisch N, Saleh M, Rohde M, Petruschka L, Burchhardt G, Schwudke D, Hermoso JA, Hammerschmidt S
  (See online at https://doi.org/10.1111/mmi.12729)
• (2015) Functional and structural characterization of DacB and PccL, lipoproteins contributing to pneumococcal pathogenesis. Dissertation, University of Greifswald
  Abdullah MR
  
• (2015) The influence of regulatory proteins on the physiology and virulence of Streptococcus pneumoniae. Dissertation University of Greifswald
  Schulz C.
  
• (2016) A Staphylococcus aureus proteome overview: Shared and specific proteins and protein complexes from representative strains of all three clades. Proteomes 4(1):8
  Liang C, Schaack D, Srivastava M, Gupta SK, Sarukhanyan E, Giese A, Pagels M, Romanov N, Pané-Farré J, Fuchs S, Dandekar T
  (See online at https://doi.org/10.3390/proteomes4010008)
• (2016) Adaptive immune response to lipoproteins of Staphylococcus aureus in healthy subjects. Proteomics 16:2667-2677
  Vu CH, Kolata J, Stentzel S, Beyer A, Gesell Salazar M, Steil L, Pané-Farré J, Rühmling V, Engelmann S, Götz F, van Dijl JM, Hecker M, Mäder U, Schmidt F, Völker U, Bröker BM
  (See online at https://doi.org/10.1002/pmic.201600151)
• (2016) Burkholderia pseudomallei colony morphotypes show a synchronized metabolic pattern after acute infection. PLoS Negl Trop Dis 10:e0004483
  Gierok P, Kohler C, Steinmetz I, Lalk M
  (See online at https://doi.org/10.1371/journal.pntd.0004483)
• (2016) Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis. Sci Rep 6:28172
  Zühlke D, Dörries K, Bernhardt J, Maass S, Muntel J, Liebscher V, Pane-Farre J, Riedel K, Lalk M, Völker U, Engelmann S, Becher D, Fuchs S, Hecker M
  (See online at https://doi.org/10.1038/srep28172)
• (2016) How does Streptococcus pneumoniae invade the brain? Trends Microbiol 24(4):307-315
  Iovino F, Seinen J, Henriques-Normark B, van Dijl JM
  (See online at https://doi.org/10.1016/j.tim.2015.12.012)
• (2016) Metabolic aspects of host pathogen interactions revealed by metabolomics. Dissertation, University of Greifswald
  Westhoff P
  
• (2016) Modular architecture and unique teichoic acid recognition features of choline-binding protein L (CbpL) contributing to pneumococcal pathogenesis. Sci Rep 5(6):38094
  Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA
  (See online at https://doi.org/10.1038/srep38094)
• (2016) Modular architecture and unique teichoic acid recognition features of choline-binding protein L (CbpL) contributing to pneumococcal pathogenesis. Sci Rep 5(6):38094
  Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA
  (See online at https://doi.org/10.1038/srep38094)
• (2016) Modular architecture and unique teichoic acid recognition features of choline-binding protein L (CbpL) contributing to pneumococcal pathogenesis. Sci Rep 5(6):38094
  Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA
  (See online at https://doi.org/10.1038/srep38094)
• (2016) Modular architecture and unique teichoic acid recognition features of choline-binding protein L (CbpL) contributing to pneumococcal pathogenesis. Sci Rep 5(6):38094
  Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA
  (See online at https://doi.org/10.1038/srep38094)
• (2016) Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. FEBS Lett 590(21):3820-3839
  Kohler S, Voß F, Gómez Mejia A, Brown JS, Hammerschmidt S
  (See online at https://doi.org/10.1002/1873-3468.12352)
• (2016) Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. FEBS Lett 590(21):3820-3839
  Kohler S, Voß F, Gómez Mejia A, Brown JS, Hammerschmidt S
  (See online at https://doi.org/10.1002/1873-3468.12352)
• (2016) Simultaneous gene finding in multiple genomes. Bioinformatics 32(22):3388–3395
  König S, Romoth LW, Gerischer L, Stanke M
  (See online at https://doi.org/10.1093/bioinformatics/btw494)
• (2016) Staphylococcus aureus infection reduces nutrition uptake and nucleotide biosynthesis in a human airway epithelial cell line. Metabolites 6(4):41
  Gierok P, Harms M, Methling K, Hochgräfe F, Lalk M
  (See online at https://doi.org/10.3390/metabo6040041)
• (2016) Thioredoxins and methionine sulfoxide reductases in the pathophysiology of pneumococcal meningitis. J Infect Dis 214(6):953-61
  Ribes S, Abdullah MR, Saleh M, Hanisch UK, Nau R, Hammerschmidt S
  (See online at https://doi.org/10.1093/infdis/jiw268)
• (2017) A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions. Sci Reports 8:9718
  Michalik S, Depke M, Murr A, Gesell Salazar M, Kusebauch U, Sun Z, Meyer TC, Surmann K, Pförtner H, Hildebrandt P, Weiss S, Palma Medina LM, Gutjahr M, Hammer E, Becher D, Pribyl T, Hammerschmidt S, Deutsch EW, Bader SL, Hecker M, Moritz RL, Mäder U, Völker U, Schmidt F
  (See online at https://doi.org/10.1038/s41598-017-10059-w)
• (2017) Global spread of mouse-adapted Staphylococcus aureus lineages CC1, CC15, and CC88 among mouse breeding facilities. Int J Med Microbiol. 2018 Aug;308(6):598-606
  Mrochen DM, Grumann D, Schulz D, Gumz J, Trübe P, Pritchett-Corning K, Johnson S, Nicklas W, Kirsch P, Martelet K, van den Brandt J, Berg S, Bröker BM, Wiles S, Holtfreter S
  (See online at https://doi.org/10.1016/j.ijmm.2017.11.006)
• (2017) Laboratory mice are frequently colonized with Staphylococcus aureus and mount a systemic immune response - Note of caution for in vivo infection experiments. Front Cell Infect Microbiol 7:152
  Schulz D, Grumann D, Trübe P, Pritchett-Corning K, Johnson S, Reppschläger K, Gumz J, Sundaramoorthy N, Michalik S, Berg S, van den Brandt J, Fister R, Monecke S, Uy B, Schmidt F, Bröker BM, Wiles S, Holtfreter S
  (See online at https://doi.org/10.3389/fcimb.2017.00152)
• (2017) Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nat Commun 2017; 8(1):2093
  Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gomez Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N
  (See online at https://doi.org/10.1038/s41467-017-01720-z)
• (2017) Signatures of cytoplasmic proteins in the exoproteome distinguish community- and hospital-associated methicillin-resistant Staphylococcus aureus USA300 lineages. Virulence 5:1-17
  Mekonnen SA, Palma Medina LM, Glasner C, Tsompanidou E, de Jong A, Grasso S, Schaffer M, Mäder U, Larsen AR, Gumpert H, Westh H, Völker U, Otto A, Becher D, van Dijl JM
  (See online at https://doi.org/10.1080/21505594.2017.1325064)
• (2017) Signatures of cytoplasmic proteins in the exoproteome distinguish community- and hospital-associated methicillin-resistant Staphylococcus aureus USA300 lineages. Virulence 5:1-17
  Mekonnen SA, Palma Medina LM, Glasner C, Tsompanidou E, de Jong A, Grasso S, Schaffer M, Mäder U, Larsen AR, Gumpert H, Westh H, Völker U, Otto A, Becher D, van Dijl JM
  (See online at https://doi.org/10.1080/21505594.2017.1325064)
• (2017) Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus. J Allergy Clin Immunol 139:492-500
  Stentzel S, Teufelberger A, Nordengrün M, Kolata J, Schmidt F, van Crombruggen K, Michalik S, Kumpfmüller J, Tischer S, Schweder T, Hecker M, Engelmann S, Völker U, Krysko O, Bachert C, Bröker B
  (See online at https://doi.org/10.1016/j.jaci.2016.03.045)
• (2017) Streptococcus pneumoniae Two- Component Regulatory Systems: The interplay of the pneumococcus with its environment. Int J Med Microbiol 2017; pii: S1438-4221(17)30382-X
  Gómez-Mejia A, Gámez G, Hammerschmidt S
  (See online at https://doi.org/10.1016/j.ijmm.2017.11.012)
• (2017) The IL-33/ST2 axis is crucial in type 2 airway responses induced by the Staphylococcus aureus protease SplD. J Allergy Clin Immunol. pii: S0091-6749(17)30793-5
  Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, O'Brien C, Provoost S, Hammad H, Gonçalves A, Beyaert R, Declercq W, Vandenabeele P, Krysko DV, Bröker BM, Bachert C, Krysko O
  (See online at https://doi.org/10.1016/j.jaci.2017.05.004)
• (2017) Wild rodents and shrews are natural hosts of Staphylococcus aureus. Int J Med Microbiol 308(6): 590-597
  Mrochen D, Schulz D, Fischer S, Jeske K, El Gohary H, Reil D, Imholt C, Trübe P, Suchomel J, Tricaud E, Jacob J, Heroldova M, Bröker BM, Walther B, Ulrich R, Holtfreter S
  (See online at https://doi.org/10.1016/j.ijmm.2017.09.014)
• (2018) Comparative Genome Annotation. In: Comparative Genomics: Methods and Protocols, Methods in Molecular Biology (eds. Setubal JC et al.). Springer 2018, vol. 1704, ISBN: 978-1-4939-7461-0
  König S, Romoth L, Stanke M
  (See online at https://doi.org/10.1007/978-1-4939-7463-4_6)
• (2018) Functional characterization of a novel protease isolated from a mouseadapted S. aureus strain. Dissertation, University of Greifswald. University Medicine of Greifswald
  El Gohary H
  
• (2018) Infection and metabolism - Streptococcus pneumoniae metabolism facing the host environment. Cytokine 2018; pii: S1043-4666(18)30319-3
  Leonard A, Lalk M
  (See online at https://doi.org/10.1016/j.cyto.2018.07.021)
• (2018) Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence. MBio. 9:1-17
  Nagel A, Michalik S, Debarbouille M, Hertlein T, Gesell Salazar M, Rath H, Msadek T, Ohlsen K, van Dijl JM, Völker U, Mäder U
  (See online at https://doi.org/10.1128/mbio.01332-18)
• (2018) Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence. MBio. 9:1-17
  Nagel A, Michalik S, Debarbouille M, Hertlein T, Gesell Salazar M, Rath H, Msadek T, Ohlsen K, van Dijl JM, Völker U, Mäder U
  (See online at https://doi.org/10.1128/mbio.01332-18)
• (2018) Intranasal vaccination with lipoproteins confers protection against pneumococcal colonisation. Frontiers in immunology 9:2405
  Voß F, Kohler TP, Meyer T, Abdullah MR, van Opzeeland FJ, Saleh M, Michalik S, van Selm S, Schmidt F, De Jonge MI, Hammerschmidt S
  (See online at https://doi.org/10.3389/fimmu.2018.02405)
• (2018) Intranasal vaccination with lipoproteins confers protection against pneumococcal colonisation. Frontiers in immunology 9:2405
  Voß F, Kohler TP, Meyer T, Abdullah MR, van Opzeeland FJ, Saleh M, Michalik S, van Selm S, Schmidt F, De Jonge MI, Hammerschmidt S
  (See online at https://doi.org/10.3389/fimmu.2018.02405)
• (2018) Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. Int J Med Microbiol 2018; pii: S1438-4221(17)30487-3
  Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M
  (See online at https://doi.org/10.1016/j.ijmm.2018.01.001)
• (2018) Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. Int J Med Microbiol 2018; pii: S1438-4221(17)30487-3
  Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M
  (See online at https://doi.org/10.1016/j.ijmm.2018.01.001)
• (2018) Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. Int J Med Microbiol 2018; pii: S1438-4221(17)30487-3
  Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M
  (See online at https://doi.org/10.1016/j.ijmm.2018.01.001)
• (2018) Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two- Component Regulatory System 08. mSphere 2018; 3(3). pii: e00165-18
  Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voss F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/msphere.00165-18)
• (2018) Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere 2018; 3(3). pii: e00165-18
  Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voss F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/mSphere.00165-1822695)
• (2018) Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere 2018; 3(3). pii: e00165-18
  Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voss F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/msphere.00165-18)
• (2018) Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08. mSphere 2018; 3(3). pii: e00165-18
  Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voß F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S
  (See online at https://doi.org/10.1128/msphere.00165-18)
• (2018) Proteomic response of Streptococcus pneumoniae to iron limitation. Int J Med Microbiol 2018; pii: S1438-4221(17)30471-X
  Hoyer J, Bartel J, Gómez-Mejia A, Rohde M, Hirschfeld C, Heß N, Sura T, Maaß S, Hammerschmidt S, Becher D
  (See online at https://doi.org/10.1016/j.ijmm.2018.02.001)
• (2018) Proteomic response of Streptococcus pneumoniae to iron limitation. Int J Med Microbiol 2018; pii: S1438-4221(17)30471-X
  Hoyer J, Bartel J, Gómez-Mejia A, Rohde M, Hirschfeld C, Heß N, Sura T, Maaß S, Hammerschmidt S, Becher D
  (See online at https://doi.org/10.1016/j.ijmm.2018.02.001)
• (2018) Proteomic response of Streptococcus pneumoniae to iron limitation. Int J Med Microbiol 2018; pii: S1438-4221(17)30471-X
  Hoyer J, Bartel J, Gómez-Mejia A, Rohde M, Hirschfeld C, Heß N, Sura T, Maaß S, Hammerschmidt S, Becher D
  (See online at https://doi.org/10.1016/j.ijmm.2018.02.001)
• (2018) Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation. Thromb Haemost 2018; 118(4):745-757
  Binsker U, Palankar R, Wesche J, Kohler TP, Prucha J, Burchhardt G, Rohde M, Schmidt F, Bröker BM, Mamat U, Pané-Farré J, Graf A, Ebner P, Greinacher A, Hammerschmidt S
  (See online at https://doi.org/10.1055/s-0038-1637735)
• (2018) Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion. Int J Med Microbiol 2018; pii: S1438-4221(17)30312-0
  Nguyen MT, Luqman A, Bitschar K, Hertlein T, Dick J, Ohlsen K, Bröker BM, Schittek B, Götz F
  (See online at https://doi.org/10.1016/j.ijmm.2017.11.013)
• (2018) Tackling the Regulation of Pneumococcal Fitness and Virulence Factors. Dissertation, University of Greifswald
  Gómez-Mejia A
  
• (2018) The hidden lipoproteome of Staphylococcus aureus. Int J Med Microbiol 2018; pii: S1438- 4221(17)30493-9
  Graf A, Lewis R J, Fuchs S, Pagels M, Engelmann S, Riedel K, Pané-Farré J
  (See online at https://doi.org/10.1016/j.ijmm.2018.01.008)
• (2018) The hidden lipoproteome of Staphylococcus aureus. Int J Med Microbiol 2018; pii: S1438- 4221(17)30493-9
  Graf A, Lewis R J, Fuchs S, Pagels M, Engelmann S, Riedel K, Pané-Farré J
  (See online at https://doi.org/10.1016/j.ijmm.2018.01.008)
• (2018) The quest for bacterial allergens. Int J Med Microbiol 2018; pii: S1438-4221(17)30504-0
  Nordengrün M, Michalik S, Völker U, Bröker BM, Gómez-Gascón L
  (See online at https://doi.org/10.1016/j.ijmm.2018.04.003)
• (2018) The serine/threonine kinase Stk and the phosphatase Stp regulate cell wall synthesis in Staphylococcus aureus. Sci Rep 2018; 8(1):13693
  Jarick M, Bertsche U, Stahl M, Schultz D, Methling K, Lalk M, Stigloher C, Steger M, Schlosser A, Ohlsen K
  (See online at https://doi.org/10.1038/s41598-018-32109-7)
• (2018) There's no place like OM: vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis. Virulence 2018; 9(1):456-464
  Gabarrini G, Palma Medina LM, Stobernack T, Prins RC, du Teil Espina M, Kuipers J, Chlebowicz MA, Rossen JWA, van Winkelhoff AJ, van Dijl JM
  (See online at https://doi.org/10.1080/21505594.2017.1421827)
• (2018) Untersuchungen zum Einfluss der Rho-Aktivität auf die Expression SaeRS- abhängiger Virulenzfaktoren in Staphylococcus aureus. Dissertation, University of Greifswald
  Nagel A
  
• (2018) Wild rodents and shrews are natural hosts of Staphylococcus aureus. Int J Med MIcrobiol 2017; pii: S1438-4221(17)30386-7
  Mrochen DM, Schulz D, Fischer S, Jeske K, El Gohary H, Reil D, Imholt C, Trübe P, Suchomel J, Tricaud E, Jacob J, Heroldova M, Bröker BM, Strommenger B, Walther B, Ulrich R, Holtfreter S
  (See online at https://doi.org/10.1016/j.ijmm.2017.09.014)
• The variome of pneumococcal virulence factors and regulators. BMC Genomics 2018; 19:10
  Gámez G, Castro A, Gómez-Mejia A, Gallego M, Bedoya A, Camargo M, Hammerschmidt S
  (See online at https://doi.org/10.1186/s12864-017-4376-0)
• (2019) Analyse der metabolischen Anpassung von Streptococcus pneumoniae an antimikrobielle Umwelteinflüsse. Dissertation, University of Greifswald
  Leornard A
  
• (2019) Between adaptation and virulence: A proteomics view on Staphylococcus aureus Infections. Dissertation, University of Greifswald
  Palma Medina LM
  
• (2019) Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains. International J Med Microbiology 2019; 309(1):26-38
  Trübe P, Hertlein T, Mrochen D, Schulz D, Jorde I, Krause B, et al.
  (See online at https://doi.org/10.1016/j.ijmm.2018.10.007)
• (2019) Eicosanoid Profile of Influenza A Virus Infected Pigs. Metabolites. 2019 Jul 3;9(7). pii: E130
  Schultz D, Methling K, KoInfekt Study Group, Rothe M, Lalk M
  (See online at https://doi.org/10.3390/metabo9070130)
• (2019) Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence 10:879-891
  Seinen J, Dieperink W, Mekonnen SA, Lisotto P, Harmsen HJM, Hiemstra B, Ott A, Schultz D, Lalk M, Oswald S, Hammerschmidt S, de Smet AMGA, van Dijl JM
  (See online at https://doi.org/10.1080/21505594.2019.1682797)
• (2019) Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence 10:879-891
  Seinen J, Dieperink W, Mekonnen SA, Lisotto P, Harmsen HJM, Hiemstra B, Ott A, Schultz D, Lalk M, Oswald S, Hammerschmidt S, de Smet AMGA, van Dijl JM
  (See online at https://doi.org/10.1080/21505594.2019.1682797)
• (2019) Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence 10:879-891
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