SPP 1656:  Intestinal Microbiota - A Microbial Ecosystem at the Edge between Immune Homeostasis and Inflammation

• Subject Area: Medicine
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 220134278

• Final Report Year: 2021

No abstract available

Publications

• Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways. Gut 2015;64:601-10
  Günther, Claudia; Buchen, Barbara; He, Gui-Wei; Hornef, Mathias; Torow, Natalia; Neumann, Helmut; Wittkopf, Nadine; Martini, Eva; Basic, Marijana; Bleich, André; Watson, Alastair J M; Neurath, Markus F & Becker, Christoph
  
• Active suppression of intestinal CD4(+)TCRalphabeta(+) T-lymphocyte maturation during the postnatal period. Nat Commun 2015;6:7725
  Torow, Natalia; Yu, Kai; Hassani, Kasra; Freitag, Jenny; Schulz, Olga; Basic, Marijana; Brennecke, Anne; Sparwasser, Tim; Wagner, Norbert; Bleich, André; Lochner, Matthias; Weiss, Siegfried; Förster, Reinhold; Pabst, Oliver & Hornef, Mathias W.
  
• Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat Immunol 2015;16:880-8
  Lindner, Cornelia; Thomsen, Irene; Wahl, Benjamin; Ugur, Milas; Sethi, Maya K; Friedrichsen, Michaela; Smoczek, Anna; Ott, Stephan; Baumann, Ulrich; Suerbaum, Sebastian; Schreiber, Stefan; Bleich, André; Gaboriau-Routhiau, Valérie; Cerf-Bensussan, Nadine; Hazanov, Helena; Mehr, Ramit; Boysen, Preben; Rosenstiel, Philip & Pabst, Oliver
  
• Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. Gut 2016;65:225-37
  Schaubeck, Monika; Clavel, Thomas; Calasan, Jelena; Lagkouvardos, Ilias; Haange, Sven Bastiaan; Jehmlich, Nico; Basic, Marijana; Dupont, Aline; Hornef, Mathias; Bergen, Martin von; Bleich, André & Haller, Dirk
  
• Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection. PLoS Pathog 2015;11:e1005008
  Rausch, Philipp; Steck, Natalie; Suwandi, Abdulhadi; Seidel, Janice A.; Künzel, Sven; Bhullar, Kirandeep; Basic, Marijana; Bleich, Andre; Johnsen, Jill M.; Vallance, Bruce A.; Baines, John F. & Grassl, Guntram A.
  
• Interferon-lambda and interleukin 22 act synergistically for the induction of interferonstimulated genes and control of rotavirus infection. Nat Immunol 2015;16:698-707
  Hernández, Pedro P; Mahlakõiv, Tanel; Yang, Ines; Schwierzeck, Vera; Nguyen, Nam; Guendel, Fabian; Gronke, Konrad; Ryffel, Bernhard; Hölscher, Christoph; Dumoutier, Laure; Renauld, Jean-Christophe; Suerbaum, Sebastian; Staeheli, Peter & Diefenbach, Andreas
  
• Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol 2016;306:343-355
  Rausch, Philipp; Basic, Marijana; Batra, Arvind; Bischoff, Stephan C.; Blaut, Michael; Clavel, Thomas; Gläsner, Joachim; Gopalakrishnan, Shreya; Grassl, Guntram A.; Günther, Claudia; Haller, Dirk; Hirose, Misa; Ibrahim, Saleh; Loh, Gunnar; Mattner, Jochen; Nagel, Stefan; Pabst, Oliver; Schmidt, Franziska; Siegmund, Britta; ... & Baines, John F.
  
• Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium. Nat Microbiol 2016;2:16215
  Brugiroux, Sandrine; Beutler, Markus; Pfann, Carina; Garzetti, Debora; Ruscheweyh, Hans-Joachim; Ring, Diana; Diehl, Manuel; Herp, Simone; Lötscher, Yvonne; Hussain, Saib; Bunk, Boyke; Pukall, Rüdiger; Huson, Daniel H.; Münch, Philipp C.; McHardy, Alice C.; McCoy, Kathy D.; Macpherson, Andrew J.; Loy, Alexander; Clavel, Thomas; ... & Stecher, Bärbel
  
• Multicenter quality assessment of 16S ribosomal DNA- sequencing for microbiome analyses reveals high inter-center variability. Int J Med Microbiol 2016;306:334-342
  Hiergeist, Andreas; Reischl, Udo & Gessner, Andrè
  
• Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut 2017;66:863-871
  Lee, Thomas; Clavel, Thomas; Smirnov, Kirill; Schmidt, Annemarie; Lagkouvardos, Ilias; Walker, Alesia; Lucio, Marianna; Michalke, Bernhard; Schmitt-Kopplin, Philippe; Fedorak, Richard & Haller, Dirk
  
• The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol 2016;1:16131
  Lagkouvardos, Ilias; Pukall, Rüdiger; Abt, Birte; Foesel, Bärbel U.; Meier-Kolthoff, Jan P.; Kumar, Neeraj; Bresciani, Anne; Martínez, Inés; Just, Sarah; Ziegler, Caroline; Brugiroux, Sandrine; Garzetti, Debora; Wenning, Mareike; Bui, Thi P. N.; Wang, Jun; Hugenholtz, Floor; Plugge, Caroline M.; Peterson, Daniel A.; Hornef, Mathias W.; ... & Clavel, Thomas
  
• Enhancement of IFNgamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. Cell Host Microbe 2017;21:682-694 e5
  Thiemann, Sophie; Smit, Nathiana; Roy, Urmi; Lesker, Till Robin; Gálvez, Eric J.C.; Helmecke, Julia; Basic, Marijana; Bleich, Andre; Goodman, Andrew L.; Kalinke, Ulrich; Flavell, Richard A.; Erhardt, Marc & Strowig, Till
  
• Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice. Gut Microbes 2019;10:188-203
  Ring, Christiane; Klopfleisch, Robert; Dahlke, Katja; Basic, Marijana; Bleich, André & Blaut, Michael
  
• Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells. Mucosal Immunol 2018;11:1621-1629
  Ruder, Barbara; Murtadak, Vinay; Stürzl, Michael; Wirtz, Stefan; Distler, Ute; Tenzer, Stefan; Mahapatro, Mousumi; Greten, Florian R.; Hu, Yinling; Neurath, Markus F.; Cesarman, Ethel; Ballon, Gianna; Günther, Claudia & Becker, Christoph
  
• Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature 2018;560:489-493
  Fulde, Marcus; Sommer, Felix; Chassaing, Benoit; van Vorst, Kira; Dupont, Aline; Hensel, Michael; Basic, Marijana; Klopfleisch, Robert; Rosenstiel, Philip; Bleich, André; Bäckhed, Fredrik; Gewirtz, Andrew T. & Hornef, Mathias W.
  
• Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat Commun 2018;9:3903
  Pezoldt, Joern; Pasztoi, Maria; Zou, Mangge; Wiechers, Carolin; Beckstette, Michael; Thierry, Guilhem R.; Vafadarnejad, Ehsan; Floess, Stefan; Arampatzi, Panagiota; Buettner, Manuela; Schweer, Janina; Fleissner, Diana; Vital, Marius; Pieper, Dietmar H.; Basic, Marijana; Dersch, Petra; Strowig, Till; Hornef, Mathias; Bleich, André; ... & Huehn, Jochen
  
• The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nat Commun 2018;9:3760
  Kindt, Alida; Liebisch, Gerhard; Clavel, Thomas; Haller, Dirk; Hörmannsperger, Gabriele; Yoon, Hongsup; Kolmeder, Daniela; Sigruener, Alexander; Krautbauer, Sabrina; Seeliger, Claudine; Ganzha, Alexandra; Schweizer, Sabine; Morisset, Rosalie; Strowig, Till; Daniel, Hannelore; Helm, Dominic; Küster, Bernhard; Krumsiek, Jan & Ecker, Josef
  
• Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate. Am J Physiol Gastrointest Liver Physiol 2019;317:G493-G507
  Kaden-Volynets, Valentina; Günther, Claudia; Zimmermann, Julia; Beisner, Julia; Becker, Christoph & Bischoff, Stephan C.
  
• Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. Inflamm Bowel Dis 2020;26:66-79
  Stolzer, Iris; Kaden-Volynets, Valentina; Ruder, Barbara; Letizia, Marilena; Bittel, Miriam; Rausch, Philipp; Basic, Marijana; Bleich, André; Baines, John F; Neurath, Markus F; Wirtz, Stefan; Weidinger, Carl; Bischoff, Stephan C; Becker, Christoph & Günther, Claudia
  
• Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest 2019;129:1972-1983
  Visekruna, Alexander; Hartmann, Sabrina; Sillke, Yasmina Rodriguez; Glauben, Rainer; Fischer, Florence; Raifer, Hartmann; Mollenkopf, Hans; Bertrams, Wilhelm; Schmeck, Bernd; Klein, Matthias; Pagenstecher, Axel; Lohoff, Michael; Jacob, Ralf; Pabst, Oliver; Bland, Paul William; Luu, Maik; Romero, Rossana; Siegmund, Britta; Rajalingam, Krishnaraj; ... & Steinhoff, Ulrich
  
• Microbial Colonization in Adulthood Shapes the Intestinal Macrophage Compartment. J Crohns Colitis 2019;13:1173-1185
  Schmidt, Franziska; Dahlke, Katja; Batra, Arvind; Keye, Jacqueline; Wu, Hao; Friedrich, Marie; Glauben, Rainer; Ring, Christiane; Loh, Gunnar; Schaubeck, Monika; Hackl, Hubert; Trajanoski, Zlatko; Schumann, Michael; Kühl, Anja A; Blaut, Michael & Siegmund, Britta
  
• Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis. Cell Host Microbe 2019;25:681-694 e8
  Herp, Simone; Brugiroux, Sandrine; Garzetti, Debora; Ring, Diana; Jochum, Lara M.; Beutler, Markus; Eberl, Claudia; Hussain, Saib; Walter, Steffi; Gerlach, Roman G.; Ruscheweyh, Hans J.; Huson, Daniel; Sellin, Mikael E.; Slack, Emma; Hanson, Buck; Loy, Alexander; Baines, John F.; Rausch, Philipp; Basic, Marijana; ... & Stecher, Bärbel
  
• Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family. Microbiome 2019;7:28
  Lagkouvardos, Ilias; Lesker, Till R.; Hitch, Thomas C. A.; Gálvez, Eric J. C.; Smit, Nathiana; Neuhaus, Klaus; Wang, Jun; Baines, John F.; Abt, Birte; Stecher, Bärbel; Overmann, Jörg; Strowig, Till & Clavel, Thomas
  
• Temporally Distinct Functions of the Cytokines IL- 12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. Immunity 2019;51:367-380 e4
  Eftychi, Christina; Schwarzer, Robin; Vlantis, Katerina; Wachsmuth, Laurens; Basic, Marijana; Wagle, Prerana; Neurath, Markus F.; Becker, Christoph; Bleich, André & Pasparakis, Manolis
  
• A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity. Nat Commun 2020;11:6389
  Wylensek, David; Hitch, Thomas C. A.; Riedel, Thomas; Afrizal, Afrizal; Kumar, Neeraj; Wortmann, Esther; Liu, Tianzhe; Devendran, Saravanan; Lesker, Till R.; Hernández, Sara B.; Heine, Viktoria; Buhl, Eva M.; M. D’Agostino, Paul; Cumbo, Fabio; Fischöder, Thomas; Wyschkon, Marzena; Looft, Torey; Parreira, Valeria R.; Abt, Birte; ... & Clavel, Thomas
  
• Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. Am J Physiol Gastrointest Liver Physiol 2020;318:G736-G747
  Jin, Cheng Jun; Baumann, Anja; Brandt, Annette; Engstler, Anna Janina; Nier, Anika; Hege, Marianne; Schmeer, Christian; Kehm, Richard; Höhn, Annika; Grune, Tilman; Witte, Otto W. & Bergheim, Ina
  
• An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell Rep 2020;30:2909-2922 e6
  Lesker, Till R.; Durairaj, Abilash C.; Gálvez, Eric J.C.; Lagkouvardos, Ilias; Baines, John F.; Clavel, Thomas; Sczyrba, Alexander; McHardy, Alice C. & Strowig, Till
  
• Bile acids drive the newborn's gut microbiota maturation. Nat Commun 2020;11:3692
  van Best, N.; Rolle-Kampczyk, U.; Schaap, F. G.; Basic, M.; Olde Damink, S. W. M.; Bleich, A.; Savelkoul, P. H. M.; von Bergen, M.; Penders, J. & Hornef, M. W.
  
• Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota. Gut Microbes 2020;12:1-17
  Fischer, Florence; Romero, Rossana; Hellhund, Anne; Linne, Uwe; Bertrams, Wilhelm; Pinkenburg, Olaf; Eldin, Hosam Shams; Binder, Kai; Jacob, Ralf; Walker, Alesia; Stecher, Bärbel; Basic, Marijana; Luu, Maik; Mahdavi, Rouzbeh; Heintz-Buschart, Anna; Visekruna, Alexander & Steinhoff, Ulrich
  
• Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp. Cell Host Microbe 2020;28:838-852 e6
  Gálvez, Eric J.C.; Iljazovic, Aida; Amend, Lena; Lesker, Till Robin; Renault, Thibaud; Thiemann, Sophie; Hao, Lianxu; Roy, Urmi; Gronow, Achim; Charpentier, Emmanuelle & Strowig, Till
  
• Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment. Sci Transl Med 2020;12
  Riba, Ambre; Hassani, Kasra; Walker, Alesia; van Best, Niels; von Zeschwitz, Dunja; Anslinger, Teresa; Sillner, Nina; Rosenhain, Stefanie; Eibach, Daniel; Maiga-Ascofaré, Oumou; Rolle-Kampczyk, Ulrike; Basic, Marijana; Binz, Anne; Mocek, Sabine; Sodeik, Beate; Bauerfeind, Rudolf; Mohs, Antje; Trautwein, Christian; Kiessling, Fabian; ... & Hornef, Mathias W.
  
• Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity 2020;53:1015-1032 e8
  Guendel, Fabian; Kofoed-Branzk, Michael; Gronke, Konrad; Tizian, Caroline; Witkowski, Mario; Cheng, Hung-Wei; Heinz, Gitta Anne; Heinrich, Frederik; Durek, Pawel; Norris, Paula S.; Ware, Carl F.; Ruedl, Christiane; Herold, Susanne; Pfeffer, Klaus; Hehlgans, Thomas; Waisman, Ari; Becher, Burkhard; Giannou, Anastasios D.; Brachs, Sebastian; ... & Diefenbach, Andreas
  
• Integrated microbiota and metabolite profiles link Crohn's disease to sulfur metabolism. Nat Commun 2020;11:4322
  Metwaly, Amira; Dunkel, Andreas; Waldschmitt, Nadine; Raj, Abilash Chakravarthy Durai; Lagkouvardos, Ilias; Corraliza, Ana Maria; Mayorgas, Aida; Martinez-Medina, Margarita; Reiter, Sinah; Schloter, Michael; Hofmann, Thomas; Allez, Matthieu; Panes, Julian; Salas, Azucena & Haller, Dirk
  
• Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities. Front Microbiol 2019;10:2999
  Eberl, Claudia; Ring, Diana; Münch, Philipp C.; Beutler, Markus; Basic, Marijana; Slack, Emma Caroline; Schwarzer, Martin; Srutkova, Dagmar; Lange, Anna; Frick, Julia S.; Bleich, André & Stecher, Bärbel