Understanding a novel class of functional polymers: Dual functional antimicrobial degradable polyesters
Zusammenfassung der Projektergebnisse
The objective of the project was to explore the possibility of forming dual functional polymers capable of showing fast antibacterial action of non-leaching contact-type and biodegradability. Emphasis was placed on (1) establishing new methods for combining antibacterial units with biodegradable polymers in order to get non-leaching antibacterial action and on (2) characterization of the resulting materials, especially with respect to their antibacterial, degradation and biocompatibility properties using standard and modified procedures. Several different strategies such as, click reactions, reactive blending, use of antibacterial macroinitiators were used for covalent attachment of antibacterial moieties with biodegradable polyesters in the form of varied macromolecular architectures. The new materials show fast antibacterial action against Gram-positive and Gram-negative bacteria. Presence of antibacterial units affect degradation kinetics as observed by carrying out the enzymatic degradability and compostability tests without hindering overall degradation of polymers. For many application areas of biodegradable polymers like sutures, implants, wound coatings etc. on one side and packaging, food storage etc. on the other side, it is reasonable to have antibacterial functionality in addition to biodegradability and the materials studied in this project could be of great interest in future.
Projektbezogene Publikationen (Auswahl)
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Antimicrobial hydantoin-grafted polycaprolactone by ring-opening polymerization and click chemistry, Macromolecular Bioscience, 2012, 12 (12), 1721–1730
Licheng Tan, Samarendra Maji, Claudia Mattheis, Yiwang Chen and Seema Agarwal
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Effect of guanidinylation on the properties of poly (2-aminoethylmethacrylate)-based antibacterial materials, Bioscience, 2013, 13 (2), 242–255
Claudia Mattheis, Hui Wang, Claus Meister and Seema Agarwal
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Oligomeric dual functional antibacterial polycaprolactone, Polym. Chem. 2014, 5, 2453-2460
Hui Wang, Christopher V. Synatschke, Alexander Raup, Valérie Jérôme, Ruth Freitag and Seema Agarwal
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Antibacterial 45S5 Bioglass®-based scaffolds reinforced with genipin cross-linked gelatin for bone tissue engineering, J. Mater. Chem. B, 2015,3, 3367-3378
Wei Li, Hui Wang, Yaping Ding, Ellen C. Scheithauer, Ourania-Menti Goudouri, Alina Grünewald, Rainer Detsch, Seema Agarwal and Aldo R. Boccaccini
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Biodegradable aliphatic-aromatic polyester with antibacterial property, Polym. Eng. Sci, Vol 56 Issue 10, October 2016, Pages 1146-1152
Hui Wang, Markus Langner, Seema Agarwal
