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Projekt Druckansicht

Systematic Reconstruction of Calcium Signaling Networks in Mitochondria

Fachliche Zuordnung Zellbiologie
Förderung Förderung von 2012 bis 2018
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 221568619
 
Erstellungsjahr 2018

Zusammenfassung der Projektergebnisse

With funding from the Emmy Noether Research Grant, we have developed a multidisciplinary research towards a systems-level understanding of mitochondria as dynamic receiver and integrators of signaling events, with a particular focus on the molecular reconstruction, pharmacological targeting and pathophysiological relevance of calcium-mediated, mitochondrial signal transduction cascades. We have successfully developed novel, systematic experimental and computational strategies that, together with quantitative, multiparametric measurements of mitochondrial functions in vivo and in vitro, have allowed us to identify genetic and chemical means for modulating mitochondrial calcium homeostasis and understanding the contribution of mitochondrial dysfunctions in animal models and human patients with neurodegenerative diseases. We will continue to combine biochemical, physiological and genetic approaches to characterize the function of newly discovered components of the mitochondrial calcium uniporter channel as well as of candidate proteins mediating signaling pathways between the ER and mitochondria. At the same time, we aim to extend our systematic experimental and computational approaches to reconstruct Ca2+-dependent signal transduction cascades in mitochondria, with a particular focus on Ca2+-mediated regulation of mitochondrial metabolism.

Projektbezogene Publikationen (Auswahl)

 
 

Zusatzinformationen

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