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Recombination processes and ancestral partitioning

Subject Area Mathematics
Term from 2012 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 221913424
 
Recombination is a major source of genetic variability in populations. It occurs during sexual reproduction and leads to the `reshuffling' of the genetic material of two parents into the type of an offspring individual. More precisely, the maternal and paternal sequences perform one or more crossovers and are cut and relinked accordingly, which results in a reciprocal exchange of genetic material.The main objective of the proposed project is to further analyse the Moran model with recombination (which describes the joint action of random reproduction and recombination in a finite population) and the corresponding ancestral partitioning process, which emerges if the genetic material of individuals taken from a population today are traced back into the past. We will also take into account the additional effects of selection and of superimposed mutation. Emphasis will be on the regime of high recombination rates, that is, on the law of large numbers and the moderate-recombination diffusion limit.
DFG Programme Priority Programmes
 
 

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