Genetic basis involved in host interaction and adaptation of Escherichia coli: Impact on crosstalk with cellular barriers (B05)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054

We aim at the identification of bacterial properties and the molecular mechanisms involved in different types of host-bacterium interaction at cellular barriers leading to infection or colonization. We want to unravel how bacteria downregulate RNA polymerase II and c-MYC-dependent host gene expression. We also want to understand how epigenetic mechanisms, like histone acetylation and DNA methylation, reprogramme innate immunity during infection with uropathogenic E. coli.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1009: Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Ulrich Dobrindt