Characterization of bioenergetic processes in mononuclear leukocytes from high-yielding dairy cows with positive and negative energy balance
Final Report Abstract
Immune response in early lactation differs highly among cows, and may be a result of metabolic and endocrine changes. Individual immune response during transition period, indicated by lymphocyte proliferation, as affected by feed intake, milk performance, methane emission, metabolism, as well as lymphocyte activation in dairy cows were investigated. Cows differed markedly in the proliferative response, but not in the metabolic and endocrine status or in their lymphocyte activation. In cows lacking the energy to sustain the shift from lymphocyte activation to proliferation, disease susceptibility might be exacerbated because energy is spent without reaching host defense. Interestingly, a positive relationship between methane emission and immune response was observed. In vitro, lymphocyte from multiparous dairy cows before and after calving responded differently to five immune modulators used. In antepartum lymphocytes the modulators seem to represent an energy source or positive extrinsic signals to use nutrients for the activation process. Whereas for lymphocytes from postpartum cows, high BHB concentrations and high insulin concentrations seem to act as negative and positive signals for lymphocytes, respectively, to utilize nutrients for activation and proliferation.
Publications
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(2018) Effect of immune modulators on in vitro activation and proliferation of peripheral blood mononuclear cells from multiparous Holstein cows peripartum. Journal of animal physiology and animal nutrition 102 (6) 1515–1520
Wang, Shaopu; Meese, Susanne; Ulbrich, Susanne E.; Bollwein, Heinrich; Röntgen, Monika; Gimsa, Ulrike; Schwarm, Angela
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(2016) Investigation on the association between methane emission and immune response in highyielding dairy cows during early lactation. Proceedings 6th Greenhouse Gas and Animal Agriculture Conference (GGAA 2016), Melbourne, Australia (Eckard R, ed.) Abstr. PO217, p. 143
Meese S, SE Ulbrich, H Bollwein, R Bruckmaier, O Wellnitz, M Kreuzer, M Röntgen, U Gimsa, A Schwarm
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(2017) The agreement between two next-generation laser methane detectors and respiration chamber facilities in recording methane concentrations in the spent air produced by dairy cows. Computers and Electronics in Agriculture, 143: 262-272
Sorg D, Mühlbach S, Rosner F, Kuhla B, Derno M, Meese S, Schwarm A, Kreuzer M, Swalve H
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(2018) Short communication: Effect of immune modulators and lactation number on in vitro proliferation of lymphocytes from non-pregnant dairy heifers and cows. Canadian Journal of Animal Science
Meese S, Gimsa U, Röntgen M, Weitzel JM, Tuchscherer A, Miersch C, Vernunft A, Viergutz T, Kreuzer M, Schwarm A
