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Multi-targeting and identification of synergistic activities to overcome therapy resistance in ALL (B06)

Subject Area Hematology, Oncology
Term from 2012 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 217328187
 
Despite high cure rates, therapy resistance is a major clinical challenge in the treatment of pediatric acute lymphoblastic leukemia (ALL). This project aims at identifying vulnerabilities and cooperative activities of single compounds and combinations of classical chemotherapeutics and agents targeting different cellular pathways. Pharmaco-profiles will be analyzed in a series of characterized patient-derived xenograft ALL samples established in our NOD/SCID/huALL system. Identified combinations showing synthetic lethality will be further pre-clinically evaluated in phase-II-like studies in our xenograft system.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Ulm
 
 

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