Gut microbiome metabolites in MS inflammation and neurodegeneration (A01)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

In the next funding period questions arising from the current study will be addressed: Does propionate (PA) has a direct neuroprotective/neuroregenerative impact, and if so, what are the mechanisms? What is the range of effects of PA on the gut tissue? Are other immune cell subsets affected, i.e. resident myeloid cells? Does long-term PA supplementation lead to a reversal of MS associated gut microbiome changes? Which metabolic factors in the gut are altered in response to PA supplementation?

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Ralf Gold; Professor Dr. Aiden Haghikia; Privatdozent Dr. Gurumoorthy Krishnamoorthy, Ph.D., until 12/2020