Antimicrobial priming, aging, antimicrobial tolerance and persistence in Escherichia coli (C05)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2012 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 190578797

When bacteria are exposed to sub-lethal concentrations of certain antimicrobial peptides, they subsequently become much more resistant against lethal concentrations of those drugs. Here we want (1) to disentangle priming mediated tolerance and persistence and their consequences experimentally, (2) to understand the role of priming under different kinetics and address the question whether the response to a continuously increasing concentration of stressors is mediated by the same mechanisms as the priming response to a single, temporary event, (3) to investigate the role of cell age on primability.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 973: Priming and Memory of Organismic Responses to Stress
• Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Jens Rolff