Unraveling the role of myeloid cells and metabolism in clinical progression of MS (B04)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

In the previous funding period we focused on antigen presenting cell / T cell interactions and their consequences on T cell plasticity in chronic neuroinflammation (e.g. Ulges et al., Nat Immunol 2016, Lückel et al., Nat Commun 2019). We now aim (1) to understand the role of G protein-coupled receptor sensing of acidification and ICER expression in CNS inflammation and disease progression, (2) to further delineate the role of ICER in metabolic reprogramming of macrophages and microglia in CNS inflammation and (3) to translate our findings to MS patients by integrating RNA sequencing from CSF cells with metabolic profiling.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Stefan Bittner, since 1/2021; Professor Dr. Tobias Bopp; Professorin Dr. Frauke Zipp, until 12/2020