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Steps to clinical xenogeneic cardiac replacement (C08)

Subject Area Cardiac and Vascular Surgery
Immunology
Term since 2012
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 213602983
 
Successful preclinical orthotopic pig-to-baboon procedures depend on: (i) stable genetic modifications, (ii) continuous non-ischemic perfusion techniques, (iii) clinically acceptable immunosuppression based on humanised non-thrombogenic anti-CD40/CD40L antibodies and (iv) omitting intrinsic (genetically derived) donor organ overgrowth using mTOR inhibitor rapamycin derivate or genetically-modified minipig breeds. Long-term results will be necessary but also provide in-depth knowledge of the various steps.
DFG Programme CRC/Transregios
 
 

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