Core facility for genetically engineered pig lines (Z03)

Subject Area Biology
Term from 2012 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 213602983
 

Project Description

The goal of this project is to provide genetically multi-modified (GM) donor pigs (originally generated and characterised in projects B1&2 and B3) for preclinical experiments: GM donors for basic studies as well as islet, heart valve, and heart transplantation studies have been delivered to Project Groups A and C. The Centre for Innovative Medical Models (CiMM) at LMU Munich has been completed with high hygienic standards (e.g. PCMV free, HEV free) and GM pig lines have been introduced via embryo transfer. PERV-C free animals have been identified and a mini-herd is being maintained. Moreover, Auckland Islet pigs have been successfully imported into the CiMM facility and will be provided as islet donors. A uniform high hygiene standard of donor pigs for preclinical transplantation studies and a pipeline, which facilitates the distribution of designated pathogen-free tissues and organs for clinical trials, will be established.
DFG Programme CRC/Transregios
Subproject of TRR 127:  Biology of Xenogeneic Cell and Organ Transplantation - From Bench to Bedside
Applicant Institution Ludwig-Maximilians-Universität München
Project Heads Professor Dr. Franz-Josef Kaup, until 6/2016; Dr. Barbara Keßler; Professor Dr. Wilfried A. Kues, since 8/2023; Dr. Andrea Lucas-Hahn, until 12/2020; Professor Dr. Heiner Niemann, until 12/2020; Dr. Björn Petersen, until 7/2023; Professorin Dr. Angelika Schnieke; Professor Dr. Eckhard Wolf