Coordination of protein synthesis and cell cycle control under stress conditions (07)

• Subject Area: Cell Biology
• Term: from 2012 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542

Molecular and functional damage causes cells to trigger adaptive stress responses, which frequently include induction of a cell cycle arrest and inhibition of global protein synthesis. Georg Stoecklin (TP07) investigates how cell cycle regulation is connected to the translational component of stress responses. The proposed work will (1) explore a novel pathway that blocks cells from entering mitosis by inhibition of the central mitotic kinase CDK1, (2) elucidate molecular components of the stress response to ribotoxins and (3) determine the mechanism by which CDK1 controls both global and specific protein synthesis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1036: Cellular Surveillance and Damage Response
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Georg Stoecklin