Project Details
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The role of Cereblon binding protein in immunomodulatory therapy of Multiple Myeloma.

Subject Area Hematology, Oncology
Human Genetics
Term from 2012 to 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 224778962
 
Final Report Year 2016

Final Report Abstract

My research was focused on the genomic characterization of Multiple Myeloma with a focus on mutation screening in the key genes of the disease and the CRBN pathway, which is cruzial for the anti-MM action of the immunomodulatory drugs. Results obtained provided evidence of targetable mutations in MM as well as biomarkers of response and survival. Furthermore we described an altered mutational landscape of drug refractory disease, however this is still not fully understood and needs to be further explored. Apart from MM we identified recurrent mutations in chronic lymphocytic leukemia and described their role in disease progression and were first to describe the entire genome of a well-differentiated liposarcoma.

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