KFO 286:  Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia

• Subject Area: Medicine
• Term: from 2013 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 226262100

• Final Report Year: 2022

No abstract available

Publications

• Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors. Sci Transl Med 2013;5:189ra78
  Riabinska, Arina; Daheim, Mathias; Herter-Sprie, Grit S.; Winkler, Johannes; Fritz, Christian; Hallek, Michael; Thomas, Roman K.; Kreuzer, Karl-Anton; Frenzel, Lukas P.; Monfared, Parisa; Martins-Boucas, Jorge; Chen, Shuhua & Reinhardt, Hans Christian
  
• Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep 2013;3:881-91
  Brinkmann, Kerstin; Zigrino, Paola; Witt, Axel; Schell, Michael; Ackermann, Leena; Broxtermann, Pia; Schüll, Stephan; Andree, Maria; Coutelle, Oliver; Yazdanpanah, Benjamin; Seeger, Jens Michael; Klubertz, Daniela; Drebber, Uta; Hacker, Ulrich T.; Krönke, Martin; Mauch, Cornelia; Hoppe, Thorsten & Kashkar, Hamid
  
• A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Cancer Discov 2014;4:592-605
  Dietlein, Felix; Thelen, Lisa; Jokic, Mladen; Jachimowicz, Ron D.; Ivan, Laura; Knittel, Gero; Leeser, Uschi; van Oers, Johanna; Edelmann, Winfried; Heukamp, Lukas C. & Reinhardt, H. Christian
  
• AKT-pathway inhibition in chronic lymphocytic leukemia reveals response relationships defined by TCL1. Curr Cancer Drug Targets 2014;14:700-12
  Schrader, Alexandra; Popal, Wagma; Lilienthal, Nils; Crispatzu, Giuliano; Mayer, Petra; Jones, Dan; Hallek, Michael & Herling, Marco
  
• Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. Leukemia 2015;29:981-4
  Huelsemann, M. F.; Patz, M.; Beckmann, L.; Brinkmann, K.; Otto, T.; Fandrey, J.; Becker, H. J.; Theurich, S.; von Bergwelt-Baildon, M.; Pallasch, C. P.; Zahedi, R. P.; Kashkar, H.; Reinhardt, H. C.; Hallek, M.; Wendtner, C. M. & Frenzel, L. P.
  
• Natural ligands and antibody-based fusion proteins: harnessing the immune system against cancer. Trends Mol Med 2014;20:72-82
  Vyas, Maulik; Koehl, Ulrike; Hallek, Michael & Strandmann, Elke Pogge von
  
• Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy. Mol Cell Oncol 2014;1:e29906
  Albert, Marie-Christine; Brinkmann, Kerstin & Kashkar, Hamid
  
• Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies? Cell Death Dis 2014;5:e1098
  Brinkmann, K. & Kashkar, H.
  
• A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study. Leukemia 2016;30:929-36
  Rawstron, A. C.; Fazi, C.; Agathangelidis, A.; Villamor, N.; Letestu, R.; Nomdedeu, J.; Palacio, C.; Stehlikova, O.; Kreuzer, K.-A.; Liptrot, S.; O'brien, D.; De Tute, R. M.; Marinov, I.; Hauwel, M.; Spacek, M.; Dobber, J.; Kater, A. P.; Gambell, P.; Soos
  
• A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Cell 2015;162:146-59
  Dietlein, Felix; Kalb, Bastian; Jokic, Mladen; Noll, Elisa M.; Strong, Alexander; Tharun, Lars; Ozretić, Luka; Künstlinger, Helen; Kambartel, Kato; Randerath, Winfried J.; Jüngst, Christian; Schmitt, Anna; Torgovnick, Alessandro; Richters, André; Rauh, Daniel; Siedek, Florian; Persigehl, Thorsten; Mauch, Cornelia; Bartkova, Jirina; ... & Reinhardt, H. Christian
  
• Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing. PLoS One 2015;10:e0129544
  Vollbrecht, Claudia; Mairinger, Fabian Dominik; Koitzsch, Ulrike; Peifer, Martin; Koenig, Katharina; Heukamp, Lukas Carl; Crispatzu, Giuliano; Wilden, Laura; Kreuzer, Karl-Anton; Hallek, Michael; Odenthal, Margarete; Herling, Carmen Diana & Buettner, Reinhard
  
• Cytotoxicity of the CD37 antibody BI 836826 against chronic lymphocytic leukaemia cells in combination with chemotherapeutic agents or PI3K inhibitors. Br J Haematol 2016;173:791-4
  Krause, Günter; Baki, Imaan; Kerwien, Susan; Knödgen, Eva; Neumann, Lars; Göckeritz, Elisa; Landwehr, Thomas; Heider, Karl‐Heinz & Hallek, Michael
  
• DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies. Front Genet 2015;6:11
  Shatnyeva, Olga M.; Hansen, Hinrich P.; Reiners, Katrin S.; Sauer, Maike; Vyas, Maulik & Strandmann, Elke Pogge von
  
• DNA repair mechanisms in cancer development and therapy. Front Genet 2015;6:157
  Torgovnick, Alessandro & Schumacher, Björn
  
• Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells. Int J Cancer 2015;137:2234-42
  Göckeritz, Elisa; Kerwien, Susan; Baumann, Michael; Wigger, Marion; Vondey, Verena; Neumann, Lars; Landwehr, Thomas; Wendtner, Clemens M.; Klein, Christian; Liu, Ningshu; Hallek, Michael; Frenzel, Lukas P. & Krause, Günter
  
• Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules 2015;5:1855-69
  Edifizi, Diletta & Schumacher, Björn
  
• miRs-138 and -424 control palmitoylationdependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL. Blood 2015;125:2948-57
  Berg, Valeska; Rusch, Marion; Vartak, Nachiket; Jüngst, Christian; Schauss, Astrid; Waldmann, Herbert; Hedberg, Christian; Pallasch, Christian P.; Bastiaens, Philippe I. H.; Hallek, Michael; Wendtner, Clemens-Martin & Frenzel, Lukas P.
  
• Mutations driving CLL and their evolution in progression and relapse. Nature 2015;526:525-30
  Landau, Dan A.; Tausch, Eugen; Taylor-Weiner, Amaro N.; Stewart, Chip; Reiter, Johannes G.; Bahlo, Jasmin; Kluth, Sandra; Bozic, Ivana; Lawrence, Mike; Böttcher, Sebastian; Carter, Scott L.; Cibulskis, Kristian; Mertens, Daniel; Sougnez, Carrie L.; Rosenberg, Mara; Hess, Julian M.; Edelmann, Jennifer; Kless, Sabrina; Kneba, Michael; ... & Wu, Catherine J.
  
• Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden. Mol Cancer 2015;14:114
  Prinz, Christian; Vasyutina, Elena; Lohmann, Gregor; Schrader, Alexandra; Romanski, Steffen; Hirschhäuser, Christoph; Mayer, Petra; Frias, Corazon; Herling, Carmen D.; Hallek, Michael; Schmalz, Hans-Günther; Prokop, Aram; Mougiakakos, Dimitrios & Herling, Marco
  
• Regulation of the DNA damage response by ubiquitin conjugation. Front Genet 2015;6:98
  Brinkmann, Kerstin; Schell, Michael; Hoppe, Thorsten & Kashkar, Hamid
  
• The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL. Leukemia 2015;29:2003-14
  Vasyutina, E.; Boucas, J. M.; Bloehdorn, J.; Aszyk, C.; Crispatzu, G.; Stiefelhagen, M.; Breuer, A.; Mayer, P.; Lengerke, C.; Döhner, H.; Beutner, D.; Rosenwald, A.; Stilgenbauer, S.; Hallek, M.; Benner, A. & Herling, M.
  
• A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair (Amst) 2016;41:8-15
  Babu, Vipin & Schumacher, Björn
  
• A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells. Mol Cancer Ther 2016;15:971-84
  Lilienthal, Nils; Lohmann, Gregor; Crispatzu, Giuliano; Vasyutina, Elena; Zittrich, Stefan; Mayer, Petra; Herling, Carmen Diana; Tur, Mehmet Kemal; Hallek, Michael; Pfitzer, Gabriele; Barth, Stefan & Herling, Marco
  
• B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. Blood 2016;127:2732-41
  Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Seeger, Jens M.; Al-Baldawi, Yussor; Al-Maarri, Mona; Fritz, Christian; Vlantis, Katerina; Bezhanova, Svetlana; Scheel, Andreas H.; Wolz, Olaf-Oliver; Reimann, Maurice; Möller, Peter; López, Cristina; Schlesner, Matthias; Lohneis, Philipp; Weber, Alexander N. R.; Trümper, Lorenz; Staudt, Louis M.; ... & Reinhardt, H. Christian
  
• CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene 2017;36:933-41
  Sauer, M.; Schuldner, M.; Hoffmann, N.; Cetintas, A.; Reiners, K. S.; Shatnyeva, O.; Hallek, M.; Hansen, H. P.; Gasser, S. & von Strandmann, E. P.
  
• Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun 2016;7:10612
  Franz, André; Pirson, Paul A.; Pilger, Domenic; Halder, Swagata; Achuthankutty, Divya; Kashkar, Hamid; Ramadan, Kristijan & Hoppe, Thorsten
  
• Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy. Blood 2016;128:395-404
  Herling, Carmen Diana; Klaumünzer, Marion; Rocha, Cristiano Krings; Altmüller, Janine; Thiele, Holger; Bahlo, Jasmin; Kluth, Sandra; Crispatzu, Giuliano; Herling, Marco; Schiller, Joanna; Engelke, Anja; Tausch, Eugen; Döhner, Hartmut; Fischer, Kirsten; Goede, Valentin; Nürnberg, Peter; Reinhardt, Hans Christian; Stilgenbauer, Stephan; Hallek, Michael; ... & Kreuzer, Karl-Anton
  
• Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment. Oncol Res Treat 2016;39:9-16
  Frenzel, Lukas P.; Reinhardt, H. Christian & Pallasch, Christian P.
  
• Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology 2016;5:e1071008
  Besse, Benjamin; Charrier, Mélinda; Lapierre, Valérie; Dansin, Eric; Lantz, Olivier; Planchard, David; Le Chevalier, Thierry; Livartoski, Alain; Barlesi, Fabrice; Laplanche, Agnès; Ploix, Stéphanie; Vimond, Nadège; Peguillet, Isabelle; Théry, Clotilde; Lacroix, Ludovic; Zoernig, Inka; Dhodapkar, Kavita; Dhodapkar, Madhav; Viaud, Sophie; ... & Chaput, Nathalie
  
• Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood 2016;128:574-83
  Thijssen, Rachel; ter Burg, Johanna; Garrick, Brett; van Bochove, Gregor G. W.; Brown, Jennifer R.; Fernandes, Stacey M.; Rodríguez, María Solé; Michot, Jean-Marie; Hallek, Michael; Eichhorst, Barbara; Reinhardt, Hans Christian; Bendell, Johanna; Derks, Ingrid A. M.; van Kampen, Roel J. W.; Hege, Kristen; Kersten, Marie José; Trowe, Torsten; Filvaroff, Ellen H.; Eldering, Eric; ... & Kater, Arnon P.
  
• E4 ligasespecific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis. Nat Struct Mol Biol 2016;23:995-1002
  Ackermann, Leena; Schell, Michael; Pokrzywa, Wojciech; Kevei, Éva; Gartner, Anton; Schumacher, Björn & Hoppe, Thorsten
  
• Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner. Mol Cancer Res 2016;14:1110-23
  Jokić, Mladen; Vlašić, Ignacija; Rinneburger, Miriam; Klümper, Niklas; Spiro, Judith; Vogel, Wenzel; Offermann, Anne; Kümpers, Christiane; Fritz, Christian; Schmitt, Anna; Riabinska, Arina; Wittersheim, Maike; Michels, Sebastian; Ozretić, Luka; Florin, Alexandra; Welcker, Daniela; Akyuz, Mehmet Deniz; Nowak, Michael; Erkel, Martin; ... & Reinhardt, Hans Christian
  
• Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial. Blood 2016;127:208-15
  Fischer, Kirsten; Bahlo, Jasmin; Fink, Anna Maria; Goede, Valentin; Herling, Carmen Diana; Cramer, Paula; Langerbeins, Petra; von Tresckow, Julia; Engelke, Anja; Maurer, Christian; Kovacs, Gabor; Herling, Marco; Tausch, Eugen; Kreuzer, Karl-Anton; Eichhorst, Barbara; Böttcher, Sebastian; Seymour, John F.; Ghia, Paolo; Marlton, Paula; ... & Hallek, Michael
  
• LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell 2016;30:610-22
  Nguyen, Phuong-Hien; Fedorchenko, Oleg; Rosen, Natascha; Koch, Maximilian; Barthel, Romy; Winarski, Tomasz; Florin, Alexandra; Wunderlich, F. Thomas; Reinart, Nina & Hallek, Michael
  
• NKp30 isoforms and NKp30 ligands are predictive biomarkers of response to imatinib mesylate in metastatic GIST patients. Oncoimmunology 2017;6:e1137418
  Rusakiewicz, Sylvie; Perier, Aurélie; Semeraro, Michaela; Pitt, Jonathan M.; Pogge von Strandmann, Elke; Reiners, Katrin S.; Aspeslagh, Sandrine; Pipéroglou, Christelle; Vély, Frédéric; Ivagnes, Alexandre; Jegou, Sarah; Halama, Niels; Chaigneau, Loic; Validire, Pierre; Christidis, Christos; Perniceni, Thierry; Landi, Bruno; Berger, Anne; Isambert, Nicolas; ... & Zitvogel, Laurence
  
• Rewired NFkappaB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma. Eur J Haematol 2016;97:499-510
  Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Pallasch, Christian P. & Reinhardt, Hans Christian
  
• Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet 2016;7:73
  Franz, André; Ackermann, Leena & Hoppe, Thorsten
  
• Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia. Leukemia 2017;31:1177-86
  Lohmann, G.; Vasyutina, E.; Bloehdorn, J.; Reinart, N.; Schneider, J. I.; Babu, V.; Knittel, G.; Crispatzu, G.; Mayer, P.; Prinz, C.; Muenzner, J. K.; Biersack, B.; Efremov, D. G.; Chessa, L.; Herling, C. D.; Stilgenbauer, S.; Hallek, M.; Schobert, R.; Re
  
• A combination of lowdose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition. Br J Cancer 2017;116:600-8
  Schiffmann, L. M.; Brunold, M.; Liwschitz, M.; Goede, V.; Loges, S.; Wroblewski, M.; Quaas, A.; Alakus, H.; Stippel, D.; Bruns, C. J.; Hallek, M.; Kashkar, H.; Hacker, U. T. & Coutelle, O.
  
• ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma. Cancer Res 2017;77:3040-56
  Schmitt, Anna; Knittel, Gero; Welcker, Daniela; Yang, Tsun-Po; George, Julie; Nowak, Michael; Leeser, Uschi; Büttner, Reinhard; Perner, Sven; Peifer, Martin & Reinhardt, Hans Christian
  
• Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue. Br J Haematol 2017;178:949-53
  Göckeritz, Elisa; Vondey, Verena; Guastafierro, Anna; Pizevska, Maja; Hassenrück, Floyd; Neumann, Lars; Hallek, Michael & Krause, Günter
  
• HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies. Blood 2017;130:1628-38
  Bobrowicz, Malgorzata; Dwojak, Michal; Pyrzynska, Beata; Stachura, Joanna; Muchowicz, Angelika; Berthel, Elise; Dalla-Venezia, Nicole; Kozikowski, Mieszko; Siernicka, Marta; Miazek, Nina; Zapala, Piotr; Domagala, Antoni; Bojarczuk, Kamil; Malenda, Agata; Barankiewicz, Joanna; Graczyk-Jarzynka, Agnieszka; Zagozdzon, Agnieszka; Gabrysiak, Magdalena; Diaz, Jean-Jacques; ... & Winiarska, Magdalena
  
• Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. Cell Rep 2017;20:2026-43
  Edifizi, Diletta; Nolte, Hendrik; Babu, Vipin; Castells-Roca, Laia; Mueller, Michael M.; Brodesser, Susanne; Krüger, Marcus & Schumacher, Björn
  
• Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Nucleic Acids Res 2017;45:9467-80
  Wilson, David M.; Rieckher, Matthias; Williams, Ashley B. & Schumacher, Björn
  
• Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nat Commun 2017;8:153
  Knittel, Gero; Rehkämper, Tim; Korovkina, Darya; Liedgens, Paul; Fritz, Christian; Torgovnick, Alessandro; Al-Baldawi, Yussor; Al-Maarri, Mona; Cun, Yupeng; Fedorchenko, Oleg; Riabinska, Arina; Beleggia, Filippo; Nguyen, Phuong-Hien; Wunderlich, F. Thomas; Ortmann, Monika; Montesinos-Rongen, Manuel; Tausch, Eugen; Stilgenbauer, Stephan; P. Frenzel, Lukas; ... & Reinhardt, H. Christian
  
• A mechanistic classification of clinical phenotypes in neuroblastoma. Science 2018;362:1165-70
  Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; ... & Fischer, Matthias
  
• Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T- PLL. Nat Commun 2018;9:697
  Schrader, A.; Crispatzu, G.; Oberbeck, S.; Mayer, P.; Pützer, S.; von Jan, J.; Vasyutina, E.; Warner, K.; Weit, N.; Pflug, N.; Braun, T.; Andersson, E. I.; Yadav, B.; Riabinska, A.; Maurer, B.; Ventura Ferreira, M. S.; Beier, F.; Altmüller, J.; Lanasa, M.; ... & Herling, M.
  
• Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Nat Commun 2018;9:727
  Herling, Carmen D.; Abedpour, Nima; Weiss, Jonathan; Schmitt, Anna; Jachimowicz, Ron Daniel; Merkel, Olaf; Cartolano, Maria; Oberbeck, Sebastian; Mayer, Petra; Berg, Valeska; Thomalla, Daniel; Kutsch, Nadine; Stiefelhagen, Marius; Cramer, Paula; Wendtner, Clemens-Martin; Persigehl, Thorsten; Saleh, Andreas; Altmüller, Janine; Nürnberg, Peter; ... & Peifer, Martin
  
• Copy-number analysis and inference of subclonal populations in cancer genomes using Sclust. Nat Protoc 2018;13:1488-501
  Cun, Yupeng; Yang, Tsun-Po; Achter, Viktor; Lang, Ulrich & Peifer, Martin
  
• Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance. Genome Med 2018;10:55
  Grasse, Sabrina; Lienhard, Matthias; Frese, Steffen; Kerick, Martin; Steinbach, Anne; Grimm, Christina; Hussong, Michelle; Rolff, Jana; Becker, Michael; Dreher, Felix; Schirmer, Uwe; Boerno, Stefan; Ramisch, Anna; Leschber, Gunda; Timmermann, Bernd; Grohé, Christian; Lüders, Heike; Vingron, Martin; Fichtner, Iduna; ... & Schweiger, Michal R.
  
• MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. Nucleic Acids Res 2018;46:6129-39
  Bianco, Julien N & Schumacher, Björn
  
• The Cdkn1a(SUPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep 2018;25:1027-39 e6
  Torgovnick, Alessandro; Heger, Jan Michel; Liaki, Vasiliki; Isensee, Jörg; Schmitt, Anna; Knittel, Gero; Riabinska, Arina; Beleggia, Filippo; Laurien, Lucie; Leeser, Uschi; Jüngst, Christian; Siedek, Florian; Vogel, Wenzel; Klümper, Niklas; Nolte, Hendrik; Wittersheim, Maike; Tharun, Lars; Castiglione, Roberta; Krüger, Marcus; ... & Reinhardt, Hans Christian
  
• Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer. Br J Cancer 2019;120:69-78
  Schiffmann, Lars Mortimer; Fritsch, Melanie; Gebauer, Florian; Günther, Saskia Diana; Stair, Neil Richard; Seeger, Jens Michael; Thangarajah, Fabinshy; Dieplinger, Georg; Bludau, Marc; Alakus, Hakan; Göbel, Heike; Quaas, Alexander; Zander, Thomas; Hilberg, Frank; Bruns, Christiane Josephine; Kashkar, Hamid & Coutelle, Oliver
  
• ATM activity in T cells is critical for immune surveillance of lymphoma in vivo. Leukemia 2020;34:771-86
  Riabinska, Arina; Lehrmann, Daria; Jachimowicz, Ron Daniel; Knittel, Gero; Fritz, Christian; Schmitt, Anna; Geyer, Aenne; Heneweer, Carola; Wittersheim, Maike; Frenzel, Lukas P.; Torgovnick, Alessandro; Wiederstein, Janica Lea; Wunderlich, Claudia Maria; Ortmann, Monika; Paillard, Arlette; Wößmann, Wilhelm; Borkhardt, Arndt; Burdach, Stefan; Hansmann, Martin-Leo; ... & Reinhardt, Hans Christian
  
• Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature 2019;575:683-7
  Fritsch, Melanie; Günther, Saskia D.; Schwarzer, Robin; Albert, Marie-Christine; Schorn, Fabian; Werthenbach, J. Paul; Schiffmann, Lars M.; Stair, Neil; Stocks, Hannah; Seeger, Jens M.; Lamkanfi, Mohamed; Krönke, Martin; Pasparakis, Manolis & Kashkar, Hamid
  
• Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing. J Mol Diagn 2019;21:198-213
  Grimm, Christina; Fischer, Axel; Farrelly, Angela M.; Kalachand, Roshni; Castiglione, Roberta; Wasserburger, Elena; Hussong, Michelle; Schultheis, Anne M.; Altmüller, Janine; Thiele, Holger; Reinhardt, H. Christian; Hauschulz, Kai; Hennessy, Bryan T.; Herwig, Ralf; Lienhard, Matthias; Buettner, Reinhard & Schweiger, Michal R.
  
• Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat Microbiol 2020;5:354-67
  Günther, Saskia D.; Fritsch, Melanie; Seeger, Jens M.; Schiffmann, Lars M.; Snipas, Scott J.; Coutelle, Maria; Kufer, Thomas A.; Higgins, Paul G.; Hornung, Veit; Bernardini, Maria L.; Höning, Stefan; Krönke, Martin; Salvesen, Guy S. & Kashkar, Hamid
  
• Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma. BMC Cancer 2019;19:531
  Schiffmann, Lars M.; Göbel, Heike; Löser, Heike; Schorn, Fabian; Werthenbach, Jan Paul; Fuchs, Hans F.; Plum, Patrick S.; Bludau, Marc; Zander, Thomas; Schröder, Wolfgang; Bruns, Christiane J.; Kashkar, Hamid; Quaas, Alexander & Gebauer, Florian
  
• iRODS metadata management for a cancer genome analysis workflow. BMC Bioinformatics 2019;20:29
  Nieroda, Lech; Maas, Lukas; Thiebes, Scott; Lang, Ulrich; Sunyaev, Ali; Achter, Viktor & Peifer, Martin
  
• Tumor Metabolism as a Regulator of Tumor-Host Interactions in the B-Cell Lymphoma Microenvironment-Fueling Progression and Novel Brakes for Therapy. Int J Mol Sci 2019;20
  Beielstein, Anna C. & Pallasch, Christian P.
  
• UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell 2019;176:505-19 e22
  Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jörg; Velpula, Bhagya Bhavana; Goergens, Jonas; Bustos, Matias A.; Doll, Markus A.; Shenoy, Anjana; Checa-Rodriguez, Cintia; Wiederstein, Janica Lea; Baranes-Bachar, Keren; Bartenhagen, Christoph; Hertwig, Falk; Teper, Nizan; Nishi, Tomohiko; Schmitt, Anna; Distelmaier, Felix; Lüdecke, Hermann-Josef; Albrecht, Beate; ... & Shiloh, Yosef
  
• CaMuS: simultaneous fitting and de novo imputation of cancer mutational signature. Sci Rep 2020;10:19316
  Cartolano, Maria; Abedpour, Nima; Achter, Viktor; Yang, Tsun-Po; Ackermann, Sandra; Fischer, Matthias & Peifer, Martin
  
• CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis 2020;11:740
  Albert, Marie-Christine; Brinkmann, Kerstin; Pokrzywa, Wojciech; Günther, Saskia Diana; Krönke, Martin; Hoppe, Thorsten & Kashkar, Hamid
  
• Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Emicro-TCL1 mice. Blood Adv 2020;4:6106-16
  Kohlhas, Viktoria; Hallek, Michael & Nguyen, Phuong-Hien
  
• Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B- Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2. Cancers (Basel) 2020;12
  Barbarino, Verena; Henschke, Sinika; Blakemore, Stuart; Izquierdo, Elena; Michalik, Michael; Nickel, Nadine; Möllenkotte, Indra; Vorholt, Daniela; Müller, Linda; Brinker, Reinhild; Fedorchenko, Oleg; Mikhael, Nelly; Seeger-Nukpezah, Tamina; Hallek, Michael & Pallasch, Christian
  
• Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Emicro-TCL1 Transgenic Mouse Model. Cancers (Basel) 2020;12(7):1980
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