Molecular mechanisms of homeostatic neuronal adaptations after denervation. (B03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 221828878

Following brain lesion, denervated neurons use multiple homeostatic mechanisms to return to their former functional state. We will (i) further characterize the regulation of homeostatic synaptic plasticity by synaptopodin and the maintenance of neuronal firing rates as control factor for the homeostatic response, (ii) focus on a newly identified player, the axon initial segment (AIS), and (iii) integrate all data gathered during the three funding periods in a single computational model to better understand the interaction of these homeostatic mechanisms.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Thomas Deller; Professor Dr. Andreas Vlachos, until 12/2016