Project Details
Projekt
Mechanisms of IL-17A-mediated pulmonary priming approaches for therapeutic interventions?
Subject Area
Pediatric and Adolescent Medicine
Term
from 2012 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 227924418
In the context of allergic bronchial asthma sensitization to one allergen constitutes a major risk factor for senstization towards other allergens and often leads to polysensitization. Available asthma therapy mainly targets the effector phase of disease and is thus primarily symptom-orientated. With this project, we aim to identify targets for modulation of bronchial asthma during the sensitization phase. In a mouse model which retraces some of the aspects of polysensitization, we have previously shown that an acute airway inflammation facilitates sensitization towards new allergens. This observation pertains not only to a Th2-polarized (eosinophil-dominated) airway inflammation but also to a Th1- or Th17-polarized (lymphocyte- or neutrophil-dominated) airway inflammation. In the context of a concomitant Th1-/Th17-polarized airway inflammation, facilitation of sensitization depends on IL-17A, a cytokine for which other investigations have suggested a role in steroid-resistent asthma.For the proposed project, we aim to identify target cells and functional effects of IL-17A on these targets cells in the context IL-17 dependent sensitization. Furthermore, we will evaluate different pharmacological agents with known effects on IL-17-dependent inflammation in our model with regards to their efficacy on sensitization and effector phase.
DFG Programme
Research Grants
