Regulation of RNA metabolism, translation and protein degradation pathways in the host response to coronavirus infection (C02)

• Subject Area: Virology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 197785619

The molecular mechanisms that determine coronavirus pathology at the cellular level are incompletely understood and new concepts are needed to suppress viral replication. Based on results from multi-level molecular analyses we will identify (i) the chromatin-based functions of CoV-activated transcription factors, (ii) the roles of ER stress kinases in selective translation, (iii) the host cell factors required for CoV replication and (iv) the molecular basis for the antiviral effects of the ER stressor thapsigargin with the long-term aim to unravel intracellular key nodes of signaling that distinguish adapted from highly pathogenic CoV and that are amenable to therapeutic intervention.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1021: RNA Viruses: RNA Metabolism, Host Response and Pathogenesis
• Applicant Institution: Philipps-Universität Marburg
• Co-Applicant Institution: Justus-Liebig-Universität Gießen
• Project Head: Professor Dr. Michael Kracht