Function and regulation of the SUMO system during hypoxia (A20)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

Post-translational modification of cellular proteins with ubiquitin-like SUMO modifiers is a dynamic process, in which SUMO-specific isopeptidass of the SENP family acts as SUMO deconjugases. We could demonstrate that in hypoxia the catalytic activity of distinct SENPs is reversibly inhibited. By comparative proteomics we defined a distinct subset of hypoxia-induced SUMO1 targets, including a set of transcriptional regulators. Based on ongoing functional experiments we propose a pathway that connects oxygen-controlled SENP activity to hypoxic reprogramming of cellular metabolism.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Stefan Müller