Shaping a lymphoma survival niche within secondary lymphoid organs

• Applicants: Privatdozentin Dr. Uta Elisabeth Höpken; Dr. Armin Rehm
• Subject Area: Hematology, Oncology ; Immunology
• Term: from 2013 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 235834047

Shaping a lymphoma survival niche within secondary lymphoid organsCrosstalk between lymphoid tumor cells and their environment provides pivotal signals for the initiation and progression of lymphoma. We will characterize stromal elements in T- and B-cell zones that collaborate with lymphoma B-cells and study lymphoma-induced cellular and molecular remodeling in indolent or aggressive lymphoma mouse models. To track lymphoma B cell migration, we will apply time-resolved confocal microscopy and live-imaging using multiphoton microscopy. Antigen-triggered BCR signaling as a pathogenetic factor in malignant B-cell survival and immunopharmacological inhibition of lymphoma-stroma crosstalk will be assessed in a murine CLL-model.

• DFG Programme: Research Grants