The role of the histone H2A deubiquitinase MYSM1 in haematopoiesis and the immune response

• Antragsteller: Michael Förster, Ph.D.
• Fachliche Zuordnung: Immunologie
• Förderung: Förderung von 2013 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 237171680

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

We have thoroughly investigated the role of Mysm1 in the development of the adaptive immune system. In addition, we investigated its role in haematopoietic stem cell function and blood cell development. Within the scope of the allocated time period funded by the DFG, we finalized a project on Usp21, a deubiquitinase related to Mysm1.

Projektbezogene Publikationen (Auswahl)

• The H2A deubiquitinase Mysm1 is Essential for Normal Fetal Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow. Stem Cells and Development, 2015 Aug 15;24(16):1865-77
  Förster M., Bell J.I. Petrov J.C., Clare S., Nijnik A.
  
• Ubiquitin Specific Protease 21 is dispensable for normal development, hematopoiesis and immunity. PLOS One 2015 Feb 13;10(2):e0117304
  Pannu J., Belle J.I., Förster M., Duerr C.U., Shen S., Kane L., Harcourt K., Fritz J.H., Clare S., Nijnik A.
  
• A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells. Immunology Vol 151 Issue 1, May 2017, Pages 110-121
  Förster M., Boora R.K., Petrov J.C., Fodil N., Albanese I., Gros P., Kim J., Nijnik A.