Project Details
Projekt
Impact of Prevotellaceae on the interplay between host and microbiota during health and disease
Applicant
Professor Dr. Till Strowig
Subject Area
Immunology
Term
from 2013 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 237379463
The intestinal microbiota is composed of hundreds of microorganisms and has important functions in the regulation of metabolism and the immune system. New scientific studies suggest that the intestinal microbiota contributes to the development of common disease such as auto inflammation and diabetes. These disease associations correlate with altered composition of the microbiota, a so-called dysbiosis.In mice lacking a part of the innate immune system, we discovered a dysbiotic microbiota that is directly responsible for the development of intestinal inflammation. We propose to use this model system to study the mechanisms the microbiota employs to modulate the immune system and to identify which specific microorganisms are responsible for exacerbating disease severity. These experiments explore new functions of the intestinal microbiota that may play important roles for human health and may enable new therapeutic approaches in the future.
DFG Programme
Priority Programmes
