Development of Enantioselective Halogen-Catalyzed Reactions

• Applicant: Dr. Thorsten H. Wöste
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2013 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 237685870

In 2011 the Muñiz group introduced an innovative concept for oxidative amination reactions under metal-free conditions. Initially, it was discovered that structurally well-defined hypervalent iodine compounds are capable of promoting a direct oxidative diamination of alkenes. This reaction is usually conducted with palladium catalysis. In the long run, the first intermolecular metal-free diamination of alkenes succeeded under enantioselective conditions.The aim of the intended research project is to develop an asymmetric diamination reaction of alkenes, which is catalytic in iodine. Stoichiometric amounts of an added oxidant should help to realize this. Thereby, different concepts will have to be elaborated. Diamines represent important building blocks in the synthesis of pharmaceutically relevant compounds. Latter ones can be prepared with simple manipulations from these ones.

• DFG Programme: Research Fellowships
• International Connection: Spain
• Host: Professor Dr. Kilian Muñiz (†)