Chronische Nierenerkrankungen und Altersforschung

• Antragsteller: Professor Dr. Tobias B. Huber
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 2013 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 237791083

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nature Medicine, Vol. 19. 2013, pp. 1288–1296.
  Canaud, G., Bienaime, F., Viau, A., Treins, C., Baron, W., Nguyen, C., Burtin, M., Berissi, S., Giannakakis, K., Muda, A. O., Zschiedrich, S., Huber, T.B., Friedlander, G., Legendre, C., Pontoglio, M., Pende, M., Terzi, F.
  
• The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes. Autophagy, Vol. 9. 2013, Issue 7, pp. 1097-1099.
  Bechtel, W., Helmstadter, M., Balica, J., Hartleben, B., Schell, C., Huber, T.B.
  
• mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the USA, Vol. 111. 2014, Issue 27, pp. E2817-E2826.
  Grahammer F., Haenisch N., Steinhardt F., Sandner L., Roerden M., Arnold F., Cordts T., Wanner N., Reichardt W., Kerjaschki D., Ruegg M.A., Hall M.N., Moulin P., Busch H., Boerries M., Walz G., Artunc F., Huber T.B.
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. New England Journal of Medicine, Vol. 371. 2014, Issue 24, pp. 2277-2287.
  Godel M., Grahammer F., Huber T.B.
  
• Albuminassociated free fatty acids induce macropinocytosis in podocytes. Journal of Clinical Investigation, Vol. 125. 2015, Issue 6, pp. 2307-2316.
  Chung, J.J., Huber, .TB., Godel, M., Jarad, G., Hartleben, B., Kwoh, C., Keil, A., Karpitskiy, A., Hu, J., Huh, C.J., Cella, M., Gross, R.W., Miner, J.H., Shaw, A.S.
  
• A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight, Vol. 1. 2016, Issue 9, e86177.
  Grahammer F., Wigge C., Schell C., Kretz O., Patrakka J., Schneider S., Klose M., Kind J., Arnold S.J., Habermann A., Bräuniger R., Rinschen M.M., Völker L., Bregenzer A., Rubbenstroth D., Boerries M., Kerjaschki D., Miner J.H., Walz G., Benzing T., Fornoni A., Frangakis A.S., Huber T.B.
  
• mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, Vol. 126. 2016, Issue 5, pp. 1773-1782.
  Grahammer F., Nesterov V., Ahmed A., Steinhardt F., Sandner L., Arnold F., Cordts T., Negrea S., Bertog M., Ruegg M.A., Hall M.N., Walz G., Korbmacher C., Artunc F., Huber T.B.
  
• Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nature Communications, Vol. 8. 2017, Issue 1, Article number: 1829.
  Henique C., Bollée G., Loyer X., Grahammer F., Dhaun N., Camus M., Vernerey J., Guyonnet L., Gaillard F., Lazareth H., Meyer C., Bensaada I., Legrès L., Satoh T., Akira S., Bruneval P., Dimmeler S., Tedgui A., Karras A., Thervet E., Nochy D., Huber T.B., Mesnard L., Lenoir O., Tharaux P.L.
  
• Targeting mTOR Signaling Can Prevent the Progression of FSGS. Journal of the American Society of Nephrology, Vol. 28. 2017, Issue 7, pp. 2144-2157.
  Zschiedrich, S., Bork, T., Liang, W., Wanner, N., Eulenbruch, K., Munder, S., Hartleben, B., Kretz, O., Gerber, S., Simons, M., Viau, A., Burtin, M., Wei, C., Reiser, J., Herbach, N., Rastaldi, M.P., Cohen, C.D., Tharaux, P.L., Terzi, F., Walz, G., Godel, M., and Huber, T.B.
  
• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Developmental Cell, Vol, 47. 2018, Issue 6, pp. 741-757.
  Schell C., Sabass B., Helmstaedter M., Geist F., Abed A., Yasuda-Yamahara M., Sigle A., Maier J.I., Grahammer F., Siegerist F., Artelt N., Endlich N., Kerjaschki D., Arnold H.H., Dengjel J., Rogg M., Huber, T.B.
  
• FERMT2 links cortical actin structures, plasma Membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biology, Vol. 68–69. 2018, pp. 263-279.
  Yasuda-Yamahara, M., Rogg, M., Frimmel, J., Trachte, P., Helmstaedter, M., Schroder, P., Schiffer, M., Schell, C., Huber, T.B.
  
• Anaerobic glycolysis maintains the glomerular filtration barrier independent of mitochondrial metabolism and dynamics. Cell Reports, Vol. 27. 2019, Issue 5, pp. 1551-1566.
  Brinkkoetter P.T., Bork T., Salou S., Liang W., Mizi A., Özel C., Koehler S., Hagmann H.H., Ising C., Kuczkowski A., Schnyder S., Abed A., Schermer B., Benzing T., Kretz O., Puelles V., Lagies S., Schlimpert M., Kammerer B., Handschin C., Schell C., Huber T.B.
  
• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. Journal of the American Society of Nephrology, Vol. 30. 2019, Issue 1, pp. 63-78.
  Wanner, N., Vornweg, J., Combes, A., Wilson, S., Plappert, J., Rafflenbeul, G., Puelles, V.G., Rahman, R.U., Liwinski, T., Lindner, S., Grahammer, F., Kretz, O., Wlodek, M.E., Romano, T., Moritz, K.M., Boerries, M., Busch, H., Bonn, S., Little, M.H., Bechtel-Walz, W., and Huber, T.B.