Chronische Nierenerkrankungen und Altersforschung

• Antragsteller: Professor Dr. Tobias B. Huber
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 2013 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 237791083

• Erstellungsjahr: 2019

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nature Medicine, Vol. 19. 2013, pp. 1288–1296.
  Canaud, Guillaume; Bienaimé, Frank; Viau, Amandine; Treins, Caroline; Baron, William; Nguyen, Clément; Burtin, Martine; Berissi, Sophie; Giannakakis, Konstantinos; Muda, Andrea Onetti; Zschiedrich, Stefan; Huber, Tobias B; Friedlander, Gérard; Legendre, Christophe; Pontoglio, Marco; Pende, Mario & Terzi, Fabiola
  
• The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes. Autophagy, Vol. 9. 2013, Issue 7, pp. 1097-1099.
  Bechtel, Wibke; Helmstädter, Martin; Balica, Jan; Hartleben, Björn; Schell, Christoph & Huber, Tobias B.
  
• mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the USA, Vol. 111. 2014, Issue 27, pp. E2817-E2826.
  Grahammer, Florian; Haenisch, Nora; Steinhardt, Frederic; Sandner, Lukas; Roerden, Malte; Arnold, Frederic; Cordts, Tomke; Wanner, Nicola; Reichardt, Wilfried; Kerjaschki, Dontscho; Ruegg, Markus A.; Hall, Michael N.; Moulin, Pierre; Busch, Hauke; Boerries, Melanie; Walz, Gerd; Artunc, Ferruh & Huber, Tobias B.
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. New England Journal of Medicine, Vol. 371. 2014, Issue 24, pp. 2277-2287.
  Tomas, Nicola M.; Beck, Laurence H.; Meyer-Schwesinger, Catherine; Seitz-Polski, Barbara; Ma, Hong; Zahner, Gunther; Dolla, Guillaume; Hoxha, Elion; Helmchen, Udo; Dabert-Gay, Anne-Sophie; Debayle, Delphine; Merchant, Michael; Klein, Jon; Salant, David J.; Stahl, Rolf A.K. & Lambeau, Gérard
  
• Albuminassociated free fatty acids induce macropinocytosis in podocytes. Journal of Clinical Investigation, Vol. 125. 2015, Issue 6, pp. 2307-2316.
  Chung, Jun-Jae; Huber, Tobias B.; Gödel, Markus; Jarad, George; Hartleben, Björn; Kwoh, Christopher; Keil, Alexander; Karpitskiy, Aleksey; Hu, Jiancheng; Huh, Christine J.; Cella, Marina; Gross, Richard W.; Miner, Jeffrey H. & Shaw, Andrey S.
  
• A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight, Vol. 1. 2016, Issue 9, e86177.
  Grahammer, Florian; Wigge, Christoph; Schell, Christoph; Kretz, Oliver; Patrakka, Jaakko; Schneider, Simon; Klose, Martin; Arnold, Sebastian J.; Habermann, Anja; Bräuniger, Ricarda; Rinschen, Markus M.; Völker, Linus; Bregenzer, Andreas; Rubbenstroth, Dennis; Boerries, Melanie; Kerjaschki, Dontscho; Miner, Jeffrey H.; Walz, Gerd; Benzing, Thomas; ... & Huber, Tobias B.
  
• mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, Vol. 126. 2016, Issue 5, pp. 1773-1782.
  Grahammer, Florian; Nesterov, Viatcheslav; Ahmed, Azaz; Steinhardt, Frederic; Sandner, Lukas; Arnold, Frederic; Cordts, Tomke; Negrea, Silvio; Bertog, Marko; Ruegg, Marcus A.; Hall, Michael N.; Walz, Gerd; Korbmacher, Christoph; Artunc, Ferruh & Huber, Tobias B.
  
• Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nature Communications, Vol. 8. 2017, Issue 1, Article number: 1829.
  Henique, Carole; Bollée, Guillaume; Loyer, Xavier; Grahammer, Florian; Dhaun, Neeraj; Camus, Marine; Vernerey, Julien; Guyonnet, Léa; Gaillard, François; Lazareth, Hélène; Meyer, Charlotte; Bensaada, Imane; Legrès, Luc; Satoh, Takashi; Akira, Shizuo; Bruneval, Patrick; Dimmeler, Stefanie; Tedgui, Alain; Karras, Alexandre; ... & Tharaux, Pierre-Louis
  
• Targeting mTOR Signaling Can Prevent the Progression of FSGS. Journal of the American Society of Nephrology, Vol. 28. 2017, Issue 7, pp. 2144-2157.
  Zschiedrich, Stefan; Bork, Tillmann; Liang, Wei; Wanner, Nicola; Eulenbruch, Kristina; Munder, Stefan; Hartleben, Björn; Kretz, Oliver; Gerber, Simon; Simons, Matias; Viau, Amandine; Burtin, Martine; Wei, Changli; Reiser, Jochen; Herbach, Nadja; Rastaldi,
  
• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Developmental Cell, Vol, 47. 2018, Issue 6, pp. 741-757.
  Schell, Christoph; Sabass, Benedikt; Helmstaedter, Martin; Geist, Felix; Abed, Ahmed; Yasuda-Yamahara, Mako; Sigle, August; Maier, Jasmin I.; Grahammer, Florian; Siegerist, Florian; Artelt, Nadine; Endlich, Nicole; Kerjaschki, Dontscho; Arnold, Hans-Henning; Dengjel, Jörn; Rogg, Manuel & Huber, Tobias B.
  
• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. Journal of the American Society of Nephrology, Vol. 30. 2019, Issue 1, pp. 63-78.
  Wanner, Nicola; Vornweg, Julia; Combes, Alexander; Wilson, Sean; Plappert, Julia; Rafflenbeul, Gesa; Puelles, Victor G.; Rahman, Raza-Ur; Liwinski, Timur; Lindner, Saskia; Grahammer, Florian; Kretz, Oliver; Wlodek, Mary E.; Romano, Tania; Moritz, Karen M.; Boerries, Melanie; Busch, Hauke; Bonn, Stefan; Little, Melissa H.; ... & Huber, Tobias B.
  
• FERMT2 links cortical actin structures, plasma Membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biology, Vol. 68–69. 2018, pp. 263-279.
  Yasuda-Yamahara, M.; Rogg, M.; Frimmel, J.; Trachte, P.; Helmstaedter, M.; Schroder, P.; Schiffer, M.; Schell, C. & Huber, T.B.
  
• Anaerobic glycolysis maintains the glomerular filtration barrier independent of mitochondrial metabolism and dynamics. Cell Reports, Vol. 27. 2019, Issue 5, pp. 1551-1566.
  Brinkkoetter, Paul T.; Bork, Tillmann; Salou, Sarah; Liang, Wei; Mizi, Athanasia; Özel, Cem; Koehler, Sybille; Hagmann, H. Henning; Ising, Christina; Kuczkowski, Alexander; Schnyder, Svenia; Abed, Ahmed; Schermer, Bernhard; Benzing, Thomas; Kretz, Oliver; Puelles, Victor G.; Lagies, Simon; Schlimpert, Manuel; Kammerer, Bernd; ... & Huber, Tobias B.