Chronische Nierenerkrankungen und Altersforschung

• Applicant: Professor Dr. Tobias B. Huber
• Subject Area: Nephrology
• Term: from 2013 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 237791083

• Final Report Year: 2019

Final Report Abstract

No abstract available

Publications

• AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nature Medicine, Vol. 19. 2013, pp. 1288–1296.
  Canaud, G., Bienaime, F., Viau, A., Treins, C., Baron, W., Nguyen, C., Burtin, M., Berissi, S., Giannakakis, K., Muda, A. O., Zschiedrich, S., Huber, T.B., Friedlander, G., Legendre, C., Pontoglio, M., Pende, M., Terzi, F.
  (See online at https://doi.org/10.1038/nm.3313)
• The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes. Autophagy, Vol. 9. 2013, Issue 7, pp. 1097-1099.
  Bechtel, W., Helmstadter, M., Balica, J., Hartleben, B., Schell, C., Huber, T.B.
  (See online at https://doi.org/10.4161/auto.24634)
• mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the USA, Vol. 111. 2014, Issue 27, pp. E2817-E2826.
  Grahammer F., Haenisch N., Steinhardt F., Sandner L., Roerden M., Arnold F., Cordts T., Wanner N., Reichardt W., Kerjaschki D., Ruegg M.A., Hall M.N., Moulin P., Busch H., Boerries M., Walz G., Artunc F., Huber T.B.
  (See online at https://doi.org/10.1073/pnas.1402352111)
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. New England Journal of Medicine, Vol. 371. 2014, Issue 24, pp. 2277-2287.
  Godel M., Grahammer F., Huber T.B.
  (See online at https://doi.org/10.1056/NEJMoa1409354)
• Albuminassociated free fatty acids induce macropinocytosis in podocytes. Journal of Clinical Investigation, Vol. 125. 2015, Issue 6, pp. 2307-2316.
  Chung, J.J., Huber, .TB., Godel, M., Jarad, G., Hartleben, B., Kwoh, C., Keil, A., Karpitskiy, A., Hu, J., Huh, C.J., Cella, M., Gross, R.W., Miner, J.H., Shaw, A.S.
  (See online at https://doi.org/10.1172/JCI79641)
• A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight, Vol. 1. 2016, Issue 9, e86177.
  Grahammer F., Wigge C., Schell C., Kretz O., Patrakka J., Schneider S., Klose M., Kind J., Arnold S.J., Habermann A., Bräuniger R., Rinschen M.M., Völker L., Bregenzer A., Rubbenstroth D., Boerries M., Kerjaschki D., Miner J.H., Walz G., Benzing T., Fornoni A., Frangakis A.S., Huber T.B.
  (See online at https://doi.org/10.1172/jci.insight.86177)
• mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, Vol. 126. 2016, Issue 5, pp. 1773-1782.
  Grahammer F., Nesterov V., Ahmed A., Steinhardt F., Sandner L., Arnold F., Cordts T., Negrea S., Bertog M., Ruegg M.A., Hall M.N., Walz G., Korbmacher C., Artunc F., Huber T.B.
  (See online at https://doi.org/10.1172/JCI80304)
• Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nature Communications, Vol. 8. 2017, Issue 1, Article number: 1829.
  Henique C., Bollée G., Loyer X., Grahammer F., Dhaun N., Camus M., Vernerey J., Guyonnet L., Gaillard F., Lazareth H., Meyer C., Bensaada I., Legrès L., Satoh T., Akira S., Bruneval P., Dimmeler S., Tedgui A., Karras A., Thervet E., Nochy D., Huber T.B., Mesnard L., Lenoir O., Tharaux P.L.
  (See online at https://doi.org/10.1038/s41467-017-01885-7)
• Targeting mTOR Signaling Can Prevent the Progression of FSGS. Journal of the American Society of Nephrology, Vol. 28. 2017, Issue 7, pp. 2144-2157.
  Zschiedrich, S., Bork, T., Liang, W., Wanner, N., Eulenbruch, K., Munder, S., Hartleben, B., Kretz, O., Gerber, S., Simons, M., Viau, A., Burtin, M., Wei, C., Reiser, J., Herbach, N., Rastaldi, M.P., Cohen, C.D., Tharaux, P.L., Terzi, F., Walz, G., Godel, M., and Huber, T.B.
  (See online at https://doi.org/10.1681/ASN.2016050519)
• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Developmental Cell, Vol, 47. 2018, Issue 6, pp. 741-757.
  Schell C., Sabass B., Helmstaedter M., Geist F., Abed A., Yasuda-Yamahara M., Sigle A., Maier J.I., Grahammer F., Siegerist F., Artelt N., Endlich N., Kerjaschki D., Arnold H.H., Dengjel J., Rogg M., Huber, T.B.
  (See online at https://doi.org/10.1016/j.devcel.2018.11.011)
• FERMT2 links cortical actin structures, plasma Membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biology, Vol. 68–69. 2018, pp. 263-279.
  Yasuda-Yamahara, M., Rogg, M., Frimmel, J., Trachte, P., Helmstaedter, M., Schroder, P., Schiffer, M., Schell, C., Huber, T.B.
  (See online at https://doi.org/10.1016/j.matbio.2018.01.003)
• Anaerobic glycolysis maintains the glomerular filtration barrier independent of mitochondrial metabolism and dynamics. Cell Reports, Vol. 27. 2019, Issue 5, pp. 1551-1566.
  Brinkkoetter P.T., Bork T., Salou S., Liang W., Mizi A., Özel C., Koehler S., Hagmann H.H., Ising C., Kuczkowski A., Schnyder S., Abed A., Schermer B., Benzing T., Kretz O., Puelles V., Lagies S., Schlimpert M., Kammerer B., Handschin C., Schell C., Huber T.B.
  (See online at https://doi.org/10.1016/j.celrep.2019.04.012)
• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. Journal of the American Society of Nephrology, Vol. 30. 2019, Issue 1, pp. 63-78.
  Wanner, N., Vornweg, J., Combes, A., Wilson, S., Plappert, J., Rafflenbeul, G., Puelles, V.G., Rahman, R.U., Liwinski, T., Lindner, S., Grahammer, F., Kretz, O., Wlodek, M.E., Romano, T., Moritz, K.M., Boerries, M., Busch, H., Bonn, S., Little, M.H., Bechtel-Walz, W., and Huber, T.B.
  (See online at https://doi.org/10.1681/ASN.2018070736)