EXC 114:  Munich Center for Integrated Protein Science (CIPSM)

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2006 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24286268

• Final Report Year: 2019

Final Report Abstract

Proteins are the principal carriers of function in each living cell and of central importance in life. At the beginning of the cluster it became apparent that proteins will be the next generation pharmaceuticals. Indeed today, proteins have revolutionized the way in which we treat cancer. The goal of the excellence cluster CIPSM was to chaperone these new developments. The CIPSM cluster established towards this goal six research areas. In the first research area, protein biophysics, CIPSM studied the stability of proteins and the forces that shape the protein universe. In the second research area CIPSM investigated the principles of proteins folding and misfolding. The third research area was devoted to study the three-dimensional structure of proteins with X-ray crystallography, cryo-electron microscopy and NMR spectroscopy. The fourth research area bundled research in the area of protein nucleic acids interactions, recognizing that proteins are intimately involved in the regulation of transcription. In the fifth research area of CIPSM, new chemical biology and protein engineering tools were developed to manipulate proteins. In research area six, CIPSM investigated proteins involved in diseases with particular emphasis on developing photo-pharmacological approaches, and protein function in systems. Systems biology was newly established in Munich by CIPSM. In all six research areas, CIPSM was able to achieve major scientific breakthroughs as demonstrated by over 2400 publications, among them 25 publications in Nature, 27 publications in Science and 15 publications in Cell. CIPSM also successfully moved scientific results into applications. The elucidation of the silk protein structure and the development of efficient expression systems led not only to high impact publications but allowed the creation of the company AMSilk GmbH. New click chemistry methods were developed to manipulate biomolecules, which delivered not only highly cited publications but led also to the establishment of the company Baseclick GmbH which now provides technologies for next generation sequencing. The CIPSM effort to create highly potent antibodies led to the development of camel-bodies and the spin-outs ChromoTek GmbH and Tubulis GmbH. New ideas to control the cellular half-life time of proteins resulted in the discovery of the Pasylation concept and foundation of the company XL-protein GmbH. The idea to turn fundamental research results into application allowed CIPSM to establish a strategic alliance with Bayer AG. Prof. Plischke, a former board member at Bayer AG and now member of the supervisory board, is teaching courses on innovation management at CIPSM attended by about 100 graduate students from TUM and LMU. CIPSM was able to submit four successful proposals for new research buildings (Bavarian NMR Center, BioSysM, CPA, and ICEM). This expands the laboratory space on the Campus Großhadern-Martinsried and Garching significantly, with an investment that exceeds 160 million Euros.

Link to the final report

https://dx.doi.org/10.2314/GBV:1696292794

Publications

• CPD Damage Recognition by Transcribing RNA Polymerase II. Science 2007
  Florian Brueckner, Ulrich Hennecke, Thomas Carell, Patrick Cramer
  
• Functional Architecture of RNA Polymerase I. Cell 2007
  Claus-D. Kuhn, Sebastian R. Geiger, Sonja Baumli, Marco Gartmann, Jochen Gerber, Stefan Jennebach, Thorsten Mielke, Herbert Tschochner, Roland Beckmann, Patrick Cramer
  
• Mechanism of transcriptional stalling at cisplatindamaged DNA. Nature Structural & Molecular Biology 2007
  Gerke E. Damsma Aaron Alt, Florian Brueckner, Thomas Carell, Patrick Cramer
  
• Molecular basis of RNA-dependent RNA polymerase II activity. Nature 2007
  Elisabeth Lehmann, Florian Brueckner, Patrick Cramer
  
• Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science 2007
  Chapman, R.D., Heidemann, M., Albert, T., Mailhammer, R., Flatley, A., Meisterernst, M., Kremmer, E., Eick, D.
  
• A nano-positioning system for macromolecular structural analysis. Nature Methods 2008
  Adam Muschielok, Joanna Andrecka, Anass Jawhari, Florian Brückner, Patrick Cramer., Jens Michaelis
  
• Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease. Science 2008
  Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, C, Staufenbiel M, Konnerth A, Garaschuk O
  
• Combined use of RNAi and quantitative proteomics to study gene function in Drosophila. Molecular Cell 2008
  Bonaldi T, Straub T, Kumar C, Cox J, Becker PB, Mann M
  
• Mechanoenzymatics of titin kinase. PNAS 2008
  Elias M. Puchner, Alexander Alexandrovich, Ay Lin Kho, Ulf Hensen, Lars V. Schäfer, Birgit Brandmeier, Frauke Gräter, Helmut Grubmüller, Hermann E. Gaub, and Mathias Gautel
  
• Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding. Cell 2008
  Shruti Sharma, Kausik Chakraborty, Barbara K. Muller, Nagore Astola, Yun-Chi Tang, Don C. Lamb, Manajit Hayer-Hartl, F. Ulrich Hartl
  
• Single-molecule tracking of mRNA exiting from RNA polymerase II. PNAS 2008
  Joanna Andrecka, Robert Lewis, Florian Brückner, Elisabeth Lehmann, Patrick Cramer, Jens Michaelis
  
• Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation. Nature Structural & Molecular Biology 2008
  Brueckner F, Cramer P
  
• Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science 2008
  Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke, B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW
  
• An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies. PNAS 2009
  D. Schönfeld, G. Matschiner, L. Chatwell, S. Trentmann, H. Gille, M. Hülsmeyer, N. Brown, P. M. Kaye, S. Schlehuber, A. M. Hohlbaum, A. Skerra
  
• An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol. Cell 2009
  Feige, M.J., Groscurth, S., Marcinowski, M., Shimizu, Y., Kessler, H., Hendershot, L.M. & Buchner, J.
  
• Dissection of the ATP- induced conformational cycle of the molecular chaperone Hsp90. Nature Structural & Molecular Biology 2009
  Hessling, M., Richter, K. & Buchner, J.
  
• Ligand-dependent equilibrium fluctuations of single calmodulin molecules. Science 2009
  Junker, J.P., Ziegler, F., Rief, M.
  
• Thymine Dimerization in DNA Model Systems: Cyclobutane Photolesion Is Predominantly Formed via the Singlet Channel. J. Am. Chem. Soc. 2009
  Julia Kubon, Nadja Regner, Karin Haiser, Tobias E. Schrader, Wolfgang Zinth, Pascale Clivio, Peter Gilch
  
• ALS‐associated fused in sarcoma (FUS) mutations disrupt Transportin‐ mediated nuclear import. EMBO J. 2010
  Dorothee Dormann, Ramona Rodde, Dieter Edbauer, Eva Bentmann, Ingeborg Fischer, Alexander Hruscha, Manuel E Than, Ian R A Mackenzie, Anja Capell, Bettina Schmid, Manuela Neumann, Christian Haass
  
• Cilengitide: The First Anti- Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation. Anti- Cancer Agents In Medicinal Chemistry 2010
  C. Mas-Moruno, F. Rechenmacher, H. Kessler
  
• Dendritic organization of sensory input to cortical neurons in vivo. Nature 2010
  Jia H, Rochefort N, Chen X, Konnerth A
  
• Molecular Basis of RNA Polymerase III Transcription Repression by Maf1. Cell 2010
  Alessandro Vannini, Rieke Ringel, Anselm G. Kusser, Otto Berninghausen, George A. Kassavetis, Patrick Cramer
  
• Uniform transitions of the general RNA polymerase II transcription complex. Nature Structural & Molecular Biology 2010
  Andreas Mayer, Michael Lidschreiber, Matthias Siebert, Kristin Leike, Johannes Söding, Patrick Cramer
  
• A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 2011
  Nikić I., Merkler D., Sorbara C., Brinkoetter M., Kreutzfeldt M., Bareyre F.M., Brück W., Bishop D., Misgeld T., Kerschensteiner M.
  
• An efficient synthesis of loline alkaloids. Nature Chemistry 2011
  Mesut Cakmak, Peter Mayer, Dirk Trauner
  
• Cytosine methylation alters DNA mechanical properties. Nucleic acids research 2011
  PMD Severin, X Zou, HE Gaub, K Schulten
  
• Functional mapping of single spines in cortical neurons in vivo. Nature 2011
  Chen X, Leischner U, Rochefort NL, Nelken I, Konnerth A
  
• Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF. Nature 2011
  Cameron D. Mackereth, Tobias Madl, Sophie Bonnal, Bernd Simon, Katia Zanier, Alexander Gasch, Vladimir Rybin, Juan Valcárcel, Michael Sattler
  
• Optochemical Genetics. Angewandte Chemie Int. Ed. 2011
  Timm Fehrentz, Matthias Schönberger, Dirk Trauner
  
• Proton detected solid-state NMR of fibrillar and membrane proteins. Angew. Chem. Int. Ed. 2011
  Linser R, Dasari M, Hiller M, Higman V, Fink U, Lopez del Amo J-M, Handel L, Kessler B, Schmieder P, Oesterhelt D, Oschkinat H, Reif B
  
• RNA polymerase II–TFIIB structure and mechanism of transcription initiation. Nature 2011
  Cheung AC, Cramer P
  
• Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nature structural & molecular biology 2011
  Franz Hagn, Stephan Lagleder, Marco Retzlaff, Julia Rohrberg, Oliver Demmer, Klaus Richter, Johannes Buchner, Horst Kessler
  
• Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins. Nature Structural & Molecular Biology 2011
  Konstantinos Tripsianes, Tobias Madl, Martin Machyna, Dimitrios Fessas, Clemens Englbrecht, Utz Fischer, Karla M Neugebauer, Michael Sattler
  
• Structural basis of RNA polymerase II backtracking, arrest and reactivation. Nature 2011
  Alan C. M. Cheung, Patrick Cramer
  
• Structure and VP16 binding of the Mediator Med25 activator interaction domain. Nature Structural & Molecular Biology 2011
  Erika Vojnic, André Mourão, Martin Seizl, Bernd Simon, Larissa Wenzeck, Laurent Larivière, Sonja Baumli, Karen Baumgart, Michael Meisterernst, Michael Sattler, Patrick Cramer
  
• The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science 2011
  Sims III, R.J., Rojas, L.A., Beck, D., Bonasio, R., Schüller, R., Drury III, W.J., Eick, D, Reinberg, D.
  
• The complex folding network of single calmodulin molecules. Science 2011
  Stigler, J., Ziegler, F., Gieseke, A., Gebhardt, J.C., Rief, M.
  
• A Movie of RNA Polymerase II Transcription. Cell 2012
  Alan C.M. Cheun, Patrick Cramer
  
• A Photochromic Agonist of AMPA Receptors. Angewandte Chemie Int. Ed. 2012
  Philipp Stawski, Martin Sumser, Dirk Trauner
  
• Azo-Propofols: Photochromic Potentiators of GABAA Receptors. Angewandte Chemie Int. Ed. 2012
  Marco Stein, Simon J. Middendorp, Valentina Carta, Ervin Pejo, Douglas E. Raines, Stuart A. Forman, Erwin Sigel, Dirk Trauner
  
• CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II. Science 2012
  Andreas Mayer, Martin Heidemann, Michael Lidschreiber, Amelie Schreieck, Mai Sun, Corinna Hintermair, Elisabeth Kremmer, Dirk Eick, Patrick Cramer
  
• CTD tyrosine phosphorylation impairs termination factor recruitment to transcribing RNA polymerase II. Science 2012
  Mayer, A., Heidemann, M., Lidschreiber, M., Schreieck, A., Sun, M., Hintermair, C., Kremmer, E., Eick, D., Cramer, P.
  
• Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Cell 2012
  Huber E. M., Basler M., Schwab R., Heinemeyer W., Kirk C., Groettrup M., Groll M.
  
• Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein–Ligand Binding. Angewandte Chemie Int. Ed. 2012
  Susanne A. I. Seidel, Christoph J. Wienken, Sandra Geissler, Moran Jerabek- Willemsen, Stefan Duhr, Alwin Reiter, Dirk Trauner , Dieter Braun, Philipp Baaske
  
• Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nature Chemistry 2012
  Ivan Tochitsky, Matthew R. Banghart, Alexandre Mourot, Jennifer Z. Yao, Benjamin Gaub, Richard H. Kramer, Dirk Trauner
  
• Rapid optical control of nociception with an ionchannel photoswitch. Nature Methods 2012
  Alexandre Mourot, Timm Fehrentz, Yves Le Feuvre, Caleb M Smith, Christian Herold, Deniz Dalkara, Frédéric Nagy, Dirk Trauner, Richard H Kramer
  
• Single-molecule dissection of the high-affinity cohesin– dockerin complex. PNAS 2012
  SW Stahl, MA Nash, DB Fried, M Slutzki, Y Barak, EA Bayer, HE Gaub
  
• Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature 2012
  Thomas Becker, Sibylle Franckenberg, Stephan Wickles, Christopher J. Shoemaker, Andreas M. Anger, Jean-Paul Armache, Heidemarie Sieber, Charlotte Ungewickell, Otto Berninghausen, Ingo Daberkow, Annette Karcher, Michael Thomm, Karl-Peter Hopfner, Rachel Green, Roland Beckmann
  
• A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis. Dev. Cell 2013
  Esther Zanin, Arshad Desai, Ina Poser, Yusuke Toyoda, Cordula Andree, Claudia Moebius, Marc Bickle, Barbara Conradt, Alisa Piekny, Karen Oegema
  
• A Pair of Centromeric Proteins Mediates Reproductive Isolation in Drosophila. Species Dev Cell 2013
  Thomae, A.W., Schade, G.O.M., Padeken, J., Borath, M.Vetter,I., Kremmer,E., Heun,P. Imhof,A.
  
• ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins. Molecular Cell 2013
  Maenner S, Müller, M, Fröhlich J, Langer D, Becker PB
  
• Dynamic readers for 5- (hydroxy)methylcytosine and its oxidized derivatives. Cell 2013
  C.G. Spruijt, F. Gnerlich, A.H. Smits, T. Pfaffeneder, P.W.T.C. Jansen, C. Bauer, M. Münzel, M. Wagner, M. Müller, F. Khan, H.C. Eberl, A. Mensinga, A.B. Brinkman, K. Lephikov, U. Müller, J. Walter, R. Boelens, H. van Ingen, H. Leonhardt, T. Carell
  
• LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell 2013
  Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B
  
• NMR Spectroscopy of Soluble Protein Complexes at One Mega‐Dalton and Beyond. Angew. Chem. Int. Ed. 2013
  Mainz, A.; Religa, T.; Sprangers, R.; Linser, R.; Kay, L. E.; Reif, B.
  
• Optical control of metabotropic glutamate receptors. Nature Neuroscience 2013
  Joshua Levitz, Carlos Pantoja, Benjamin Gaub, Harald Janovjak, Andreas Reiner, Adam Hoagland, David Schoppik, Brian Kane, Philipp Stawski, Alexander F Schier, Dirk Trauner, Ehud Y Isacoff
  
• RNA polymerase I structure and transcription regulation. Nature 2013
  Christoph Engel, Sarah Sainsbury, Alan C. Cheung, Dirk Kostrewa, Patrick Cramer
  
• Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature 2013
  Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang E, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E, Ladurner AG
  
• Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013
  Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP
  
• Structures of the human and Drosophila 80S ribosome. Nature 2013
  Andreas M. Anger, Jean-Paul Armache, Otto Berninghausen, Michael Habeck, Marion Subklewe, Daniel N. Wilson, Roland Beckmann
  
• The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase. J. Am. Chem. Soc. 2013
  Pester, O., Barrett, P.J., Hornburg, D., Hornburg, P., Proebstle, R., Widmaier, S., Kutzner, C., Duerrbaum, M., Kapurniotu, A., Sanders, C.R., Scharnagl, C., Langosch, D.
  
• Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis. Cell 2013
  Daniel Schulz, Bjoern Schwalb, Anja Kiesel, Carlo Baejen, Phillipp Torkler, Julien Gagneur, Johannes Soeding, Patrick Cramer
  
• Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches. Science 2013
  Susanne Ude, Jürgen Lassak, Agata L. Starosta, Tobias Kraxenberger, Daniel N. Wilson, Kirsten Jung
  
• Uptake Kinetics and Nanotoxicity of Silica Nanoparticles are Cell Type Dependent. Small 2013
  Blechinger J., Bauer A.T., Torrano A.A., Gorzelanny C., Bräuchle C., Schneider S.W.
  
• GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding. Cell 2014
  Georgescauld F, Popova K, Gupta JA, Bracher A, Engen JR, Hayer-Hartl M, Hartl FU
  
• High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat. Commun. 2014
  Grimm C, Holdt LM, Chen CC, Hassan, H, Jörs S Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Müller C, Spahn S, Castonguay J, Luber CA, Moser M, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C
  
• Mass-spectrometry-based draft of the human proteome. Nature 2014
  Wilhelm M, Schlegl J, Hahne H, Gholami AM, Lieberenz M, Savitski MM, Ziegler E, Butzmann L, Gessulat S, Marx H, Mathieson T, Lemeer S, Schnatbaum K, Reimer U, Wenschuh H, Mollenhauer M, Slotta-Huspenina J, Boese JH, Bantscheff M, Gerstmair A, Faerber F, Kuster B
  
• Multi-parametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nature Medicine 2014
  Breckwoldt M.O., Pfister F., Bradley P.M., Marinkovic P., Williams P.W., Brill M.S., Plomer B., Schmalz A., St Clair D.K., Naumann R., Griesbeck O., Schwarzländer M., Godinho L., Bareyre F.M., Dick T.P., Kerschensteiner M. , Misgeld T.
  
• Structural basis for the assembly of the Sxl–Unr translation regulatory complex. Nature 2014
  Janosch Hennig, Cristina Militti, Grzegorz M. Popowicz, Iren Wang, Miriam Sonntag, Arie Geerlof, Frank Gabel, Fátima Gebauer, Michael Sattler
  
• Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion. Nature 2014
  Marko Gogala, Thomas Becker, Birgitta Beatrix, Jean- Paul Armache, Clara Barrio-Garcia, Otto Berninghausen, Roland Beckmann
  
• Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nat. Chem Biol 2014
  Spada, M. Wagner, C. Brandmayr, S. K. Laube, D. Eisen, M. Truss, J. Steinbacher, B. Hackner, O. Kotl-jarova, D. Schuermann, S. Michalakis, O. Kosmatchev, S. Schiesser, B. Steigenberger, N. Raddaoui, G. Kashiwazaki, U. Müller, C. G. Spruijt, M. Vermeulen, H. Leonhardt, P. Schar, M. Müller, T. Carell
  
• A tunable azine-covalent organic framework platform for light-induced hydrogen generation. Nat. Commun. 2015
  V. S. Vyas, F. Haase, L. Stegbauer, G. Savasci, F. Podjaski, C. Ochsenfeld, B.V.
  
• AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control. Nat. Commun. 2015
  Malte Gersch, Kirsten Famulla, Maria Dahmen, Christoph Göbl, Imran Malik, Klaus Richter, Vadim S. Korotkov, Peter Sass, Helga Rübsamen-Schaeff, Tobias Madl, Heike Brötz-Oesterhelt & Stephan A. Sieber
  
• An eight-step synthesis of epicolactone reveals its biosynthetic origin. Nature Chemistry 2015
  Pascal Ellerbrock, Nicolas Armanino, Marina K. Ilg, Robert Webster, Dirk Trauner
  
• Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nature chemical biology 2015
  Jürgen Lassak, Eva C Keilhauer, Maximilian Fürst, Kristin Wuichet, Julia Gödeke, Agata L Starosta, Jhong-Min Chen, Lotte Søgaard-Andersen, Jürgen Rohr, Daniel N Wilson, Susanne Häussler, Matthias Mann, Kirsten Jung
  
• DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links. Science 2015
  Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M
  
• Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components. Science 2015
  Gerling, K. Wagenbauer, A. Neuner, H. Dietz
  
• Engulfment path-ways promote programmed cell death by enhancing the unequal segregation of apoptotic potential. Nat. Commun. 2015
  Chakraborty, S., Lambie, E.J., Bindu, S., Mikeladze-Dvali, T., Conradt, B.
  
• FAX1, a Novel Membrane Protein Mediating Plastid Fatty Acid Export. PLOS Biology 2015
  Li, N., Gügel, I.L., Giavalsico, P., Zeisler, V., Schreiber, L., Soll, J., Philippar, K.
  
• Fully Blind Peptide-Protein Docking with pepATTRACT. Structure 2015
  Schindler C. E., de Vries S. J., Zacharias M.
  
• Global and specific responses of the histone acetylome to systematic perturbation. Molecular Cell 2015
  Feller C, Forné I, Imhof A, Becker PB
  
• Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. Cell 2015
  Malgorzata Borowiak, Wallis Nahaboo, Martin Reynders, Katharina Nekolla, Pierre Jalinot, Jens Hasserodt, Markus Rehberg, Marie Delattre, Stefan Zahler, Angelika Vollmar, Dirk Trauner, Oliver Thorn-Seshold
  
• Sunlight Powered kHz Rotation of a Hemithioindigo Based Molecular Motor. Nat. Commun. 2015
  M. Guentner, M. Schildhauer, S. Thumser, P. Mayer, D. Stephenson, P. J. Mayer, H. Dube
  
• TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. Cell Rep. 2015
  A. Perera, D. Eisen, M. Wagner, S. K. Laube, A. F. Künzel, S. Koch, J. Steinbacher, E. Schulze, V. Splith, N. Mittermeier, M. Müller, M. Biel, T. Carell, S. Michalakis
  
• The Chaperone αB- Crystallin Deploys Different Interfaces to Capture an Amorphous and an Amyloid Client. Nature structural & molecular biology 2015
  Mainz A, Peschek J, Stavropoulou M, Back K, Bardiaux B, Asami S, Prade E, Peters C, Weinkauf S, Buchner J, Reif B
  
• Two distinct modes for propagation of histone PTMs across the cell cycle. Genes & Dev. 2015
  Alabert, C., Barth, T.K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O.N., Imhof, A., Groth, A.
  
• Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment. Science 2015
  Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA
  
• A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway. Science 2016
  S. Becker, I. Thoma, A. Deutsch, T. Gehrke, P. Mayer, H. Zipse, T. Carell
  
• Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature 2016
  Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU
  
• PionX sites mark the X chromosome for dosage compensation. Nature 2016
  Villa R, Schauer T, Smialowski P, Straub T, Becker PB
  
• Biotechnological mass production of DNA origami. Nature 2017
  F. Praetorius, B. Kick, K. Behler, M. Honemann, D. Weuster- Botz, H. Dietz
  
• Building ProteomeTools based on a complete synthetic human proteome. Nat Methods 2017
  Daniel P Zolg, Mathias Wilhelm ,Karsten Schnatbaum, Johannes Zerweck, Tobias Knaute, Bernard Delanghe, Derek J Bailey, Siegfried Gessulat, Hans-Christian Ehrlich, Maximilian Weininger, Peng Yu, Judith Schlegl, Karl Kramer, Tobias Schmidt, Ulrike Kusebauch, Eric W Deutsch, Ruedi Aebersold, Robert L Moritz, Holger Wenschuh, Thomas Moehring, Stephan Aiche, Andreas Huhmer, Ulf Reimer, Bernhard Kuster
  
• cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein- DNA ladders. Nature 2017
  Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP
  
• Gigadalton-scale shapeprogrammable DNA assemblies. Nature 2017
  K. Wagenbauer, C. Sigl, H. Dietz
  
• Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization. Angew. Chem. Int. Ed 2017
  Anna Sib, Tobias A. M. Gulder
  
• The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell 2017
  Gaidt, M. M., Ebert, T. S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O'Duill, F., Schmid-Burgk, J. L., Hoss, F., Buhmann, R., Wittmann, G., Latz, E., Subklewe, M., Hornung, V.
  
• The target landscape of clinical kinase drugs. Science 2017
  Susan Klaeger, ... Sabine Schneider, ... Bernhard Kuster
  
• Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins. Nucleic Acids Research 2019
  Valentina Corvaglia, Daniel Carbajo, Panchami Prabhakaran, Krzysztof Ziach, Pradeep Kumar Mandal, Victor Dos Santos, Carole Legeay, Rachel Vogel, Vincent Parissi, Philippe Pourquier , Ivan Huc
  
• Cell type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nature Neuroscience 2019
  Fecher C., Trovò L., Müller S.A., Snaidero N., Wettmarshausen J., Heink S., Ortiz O., Hartmann J., Karl R.M., Konnerth A., Korn T., Wurst W., Merkler D., Lichtenthaler S.F., Perocchi F., Misgeld T.
  
• Directional Threading and Sliding of a Dissymmetrical Foldamer Helix on Dissymmetrical Axles. Angewandte Chemie Int. Ed. 2019
  Xiang Wang, Quan Gan, Barbara Wicher, Yann Ferrand, Ivan Huc
  
• Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science 2019
  Sidney Becker, Jonas Feldmann, Stefan Wiedemann Hidenori Okamura, Christina Schneider, Katharina Iwan, Antony Crisp, Martin Rossa, Tynchtyk Amatov, Thomas Carell