GSC 106:  Graduate School for Life Sciences (GSLS)

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2006 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24389404

• Final Report Year: 2020

Final Report Abstract

Research in the life sciences is moving forward at a tremendous speed and one cannot imagine to pursue a successful career without a multi-disciplinary approach, the ability to quickly adapt to new topics and technologies, and to utilize these to address important questions within the field of interest. The Graduate School of Life Sciences at the University of Würzburg (JMU) provides an ideal platform to prepare doctoral researchers and postdocs to meet these demands. The GSLS comprises members from the faculties of Biology, Medicine, Chemistry and Pharmacy, Physics, and Human Sciences (Psychology). The key to a successful graduate career is a personally tailored and structured graduate program that prepares the doctoral researchers for their future careers. The GSLS has therefore established five sections which cover a wide spectrum in the life sciences and trains doctoral researchers for demanding future careers: Biomedicine, Infection and Immunity, Neuroscience and Behavior, Integrative Biology, and Clinical Sciences. Each section defines its own scientific and methods program, thus permitting all doctoral researchers within the GSLS to design their optimal educational program which is not restricted to one section but also provides the possibility for the doctoral researcher to freely select from the entire spectrum of courses. Over the past 12 years, the Graduate School of Life Sciences (GSLS) has succeeded to be one of the first institutions Germany-wide to set landmark standards for the support and career development of doctoral researchers, thereby being a central driving force for major reforms and adjustments in doctoral training nation-wide. With a training program tailored to personal strengths and developmental needs, the GSLS offers all doctoral researchers in the life sciences the possibility to optimally develop their professional careers. Without distracting from scientific research at the core of each doctorate, the GSLS promotes and supports its doctoral researchers and thereby makes them highly attractive candidates for both academic research and employers outside of academia. After a highly successful 1st funding period our experience with doctoral training in the life sciences led to the expansion of the GSLS concept to the medical doctoral phase, to the master phase as well as the postdoctoral phase in the 2nd funding phase, thus providing an ideal interdisciplinary platform covering the entire path from the Undergraduate to the Postdoc. In total more than 390 principal investigators have joined the GSLS since 2006, supervising more 1300 natural science doctoral researchers and 230 medical doctoral researchers. Approximately 35% of the current natural science doctoral researchers come from countries other than Germany and are eager to nurture their scientific excitement at JMU and with the support of the GSLS. An added value is thus the strong impact on international visibility of the entire University which would have not been possible without the funds from the Excellence Initiative.

Publications

• Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Oncogene. 2008 Nov 27;27(56):7070-82
  Leikam C, Hufnagel A, Schartl M, Meierjohann S
  (See online at https://doi.org/10.1038/onc.2008.323)
• STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood. 2009 Jan 29;113(5):1097-104
  Braun A, Gessner JE, Varga-Szabo D, Syed SN, Konrad S, Stegner D, Vögtle T, Schmidt RE, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2008-05-158477)
• STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal. 2009 Oct 20;2(93):ra67
  Berna-Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B
  (See online at https://doi.org/10.1126/scisignal.2000522)
• ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 9;116(10):1767-75
  Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2010-03-274340)
• Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood. 2010 Oct 28;116(17):3347-55
  Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2010-06-289108)
• Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal. 2010 Jan 5;3(103):ra1
  Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, Kuijpers ME, Boesl M, Chen Q, Heemskerk JW, Stoll G, Frohman MA, Nieswandt B
  (See online at https://doi.org/10.1126/scisignal.2000551)
• The role of the dopamine transporter in dopamine-induced DNA damage. Brain Pathol. 2011 May;21(3):237-48
  Fazeli G, Oli RG, Schupp N, Stopper H
  (See online at https://doi.org/10.1111/j.1750-3639.2010.00440.x)
• Attracting the attention of a fly. Proc Natl Acad Sci USA. 2011 Apr 26;108(17):7230-5
  Sareen P, Wolf R, Heisenberg M
  (See online at https://doi.org/10.1073/pnas.1102522108)
• Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47. J Neurosci. 2011 Mar 2;31(9):3508-18
  Saumweber T, Weyhersmüller A, Hallermann S, Diegelmann S, Michels B, Bucher D, Funk N, Reisch D, Krohne G, Wegener S, Buchner E, Gerber B
  (See online at https://doi.org/10.1523/JNEUROSCI.2646-10.2011)
• Integrating neurobiological markers of depression. Arch Gen Psychiatry. 2011 Apr;68(4):361-8
  Hahn T, Marquand AF, Ehlis AC, Dresler T, Kittel-Schneider S, Jarczok TA, Lesch KP, Jakob PM, Mourao-Miranda J, Brammer MJ, Fallgatter AJ
  (See online at https://doi.org/10.1001/archgenpsychiatry.2010.178)
• Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant. Cereb Cortex. 2011 Jul;21(7):1659-66
  Hahn T, Heinzel S, Plichta MM, Reif A, Lesch KP, Fallgatter AJ
  (See online at https://doi.org/10.1093/cercor/bhq236)
• The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Diabetes. 2011 Jul;60(7):1955-63
  Gerold KD, Zheng P, Rainbow DB, Zernecke A, Wicker LS, Kissler S
  (See online at https://doi.org/10.2337/db11-0130)
• Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state. EMBO J. 2012 Aug 1;31(15):3363-74
  Königsberger S, Prodöhl J, Stegner D, Weis V, Andreas M, Stehling M, Schumacher T, Böhmer R, Thielmann I, van Eeuwijk JM, Nieswandt B, Kiefer F
  (See online at https://doi.org/10.1038/emboj.2012.169)
• Cholesterol loss during glutamate-mediated excitotoxicity. EMBO J. 2012 Apr 4;31(7):1764-73
  Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG
  (See online at https://doi.org/10.1038/emboj.2012.31)
• CLP36 is a negative regulator of glycoprotein VI signaling in platelets. Circ Res. 2012 Nov 9;111(11):1410-20
  Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B
  (See online at https://doi.org/10.1161/CIRCRESAHA.112.264754)
• Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature. 2012 Mar 28;483(7391):608-12
  Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ
  (See online at https://doi.org/10.1038/nature10927)
• Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood. 2012 Jan 26;119(4):1054-63
  Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2011-08-372193)
• Fly cryptochrome and the visual system. Proc Natl Acad Sci USA. 2013 Apr 9;110(15):6163-8
  Mazzotta G, Rossi A, Leonardi E, Mason M, Bertolucci C, Caccin L, Spolaore B, Martin AJ, Schlichting M, Grebler R, Helfrich-Förster C, Mammi S, Costa R, Tosatto SC
  (See online at https://doi.org/10.1073/pnas.1212317110)
• Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J Clin Invest. 2013 August 1; 123(8): 3331–3342
  Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B
  (See online at https://doi.org/10.1172/JCI69210)
• Hebbian plasticity guides maturation of glutamate receptor fields in vivo. Cell Rep. 2013 May 30;3(5):1407-13
  Ljaschenko D, Ehmann N, Kittel RJ
  (See online at https://doi.org/10.1016/j.celrep.2013.04.003)
• High-resolution transcriptome maps reveal strain-specific regulatory features of multiple Campylobacter jejuni isolates. PLoS Genet. 2013 May;9(5):e1003495
  Dugar G, Herbig A, Förstner KU, Heidrich N, Reinhardt R, Nieselt K, Sharma CM
  (See online at https://doi.org/10.1371/journal.pgen.1003495)
• MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. Circulation. 2013 May 28;127(21):2097-106
  Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S
  (See online at https://doi.org/10.1161/CIRCULATIONAHA.112.000882)
• Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomaldominant hypotrichosis simplex. Am J Hum Genet. 2013 Jan 10;92(1):81-7
  Pasternack SM, Refke M, Paknia E, Hennies HC, Franz T, Schäfer N, Fryer A, van Steensel M, Sweeney E, Just M, Grimm C, Kruse R, Ferrándiz C, Nöthen MM, Fischer U, Betz RC
  (See online at https://doi.org/10.1016/j.ajhg.2012.10.022)
• Overproduction of flotillin influences cell differentiation and shape in Bacillus subtilis. MBio. 2013 Nov 12;4(6):e00719-13
  Mielich-Süss B, Schneider J, Lopez D
  (See online at https://doi.org/10.1128/mBio.00719-13)
• PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a lossof-function variant. Diabetes 2013 Mar;62(3):896-904
  Zheng P, Kissler S
  (See online at https://doi.org/10.2337/db12-0929)
• BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues. Cell Rep. 2014 Sep 11;8(5):1347-53
  Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ
  (See online at https://doi.org/10.1016/j.celrep.2014.07.057)
• Comparative landscape genetics of two river frog species occurring at different elevations on Mount Kilimanjaro. Mol Ecol. 2014 Oct;23(20):4989-5002
  Zancolli G, Rödel MO, Steffan-Dewenter I, Storfer A
  (See online at https://doi.org/10.1111/mec.12921)
• Cystathionase mediates senescence evasion in melanocytes and melanoma cells. Oncogene. 2014 Feb 6;33(6):771-82
  Leikam C, Hufnagel A, Walz S, Kneitz S, Fekete A, Müller MJ, Eilers M, Schartl M, Meierjohann S
  (See online at https://doi.org/10.1038/onc.2012.641)
• Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott- Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 4;5:4746
  Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B
  (See online at https://doi.org/10.1038/ncomms5746)
• Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun. 2014 Aug 18;5:4650
  Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ
  (See online at https://doi.org/10.1038/ncomms5650)
• Specificity and transcriptional activity of microbiota associated with low and high microbial abundance sponges from the Red Sea. Mol Ecol. 2014 Mar;23(6):1348-1363
  Moitinho-Silva L, Bayer K, Cannistraci CV, Giles EC, Ryu T, Seridi L, Ravasi T, Hentschel U
  (See online at https://doi.org/10.1111/mec.12365)
• Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1). Cell Death Dis. 2014 Mar 27;5:e1149
  Diessner J, Bruttel V, Stein RG, Horn E, Häusler SF, Dietl J, Hönig A, Wischhusen J
  (See online at https://doi.org/10.1038/cddis.2014.115)
• Accumulation of extra-chloroplastic triacylglycerols in Arabidopsis seedlings during heat acclimation. J Exp Bot. 2015 Aug;66(15):4517-26
  Mueller SP, Krause DM, Mueller MJ, Fekete A
  (See online at https://doi.org/10.1093/jxb/erv226)
• Annual Research Review: The (epi)genetics of neurodevelopmental disorders in the era of wholegenome sequencing - unveiling the dark matter. J Child Psychol Psychiatry. 2015 Mar;56(3):278-95
  Kiser DP, Rivero O, Lesch KP
  (See online at https://doi.org/10.1111/jcpp.12392)
• Calcium sensor kinase activates potassium uptake systems in gland cells of Venus flytraps. Proc Natl Acad Sci USA. 2015 Jun 9;112(23):7309-14
  Scherzer S, Böhm J, Krol E, Shabala L, Kreuzer I, Larisch C, Bemm F, Al-Rasheid KA, Shabala S, Rennenberg H, Neher E, Hedrich R
  (See online at https://doi.org/10.1073/pnas.1507810112)
• Elicitation of secondary metabolism in actinomycetes. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):798-811
  Abdelmohsen UR, Grkovic T, Balasubramanian S, Kamel MS, Quinn RJ, Hentschel U
  (See online at https://doi.org/10.1016/j.biotechadv.2015.06.003)
• High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virusand tumor-derived antigens. Blood. 2015 Jul 9;126(2):185-94
  Wegner J, Hackenberg S, Scholz CJ, Chuvpilo S, Tyrsin D, Matskevich AA, Grigoleit GU, Stevanović S, Hünig T
  (See online at https://doi.org/10.1182/blood-2015-01-622704)
• In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells. Cell Death Dis. 2015 Apr 2;6:e1711
  Leikam C, Hufnagel AL, Otto C, Murphy DJ, Mühling B, Kneitz S, Nanda I, Schmid M, Wagner TU, Haferkamp S, Bröcker EB, Schartl M, Meierjohann S
  (See online at https://doi.org/10.1038/cddis.2015.71)
• ITS2 database V: Twice as much. Mol Biol Evol. 2015 Nov;32(11):3030-2
  Ankenbrand MJ, Keller A, Wolf M, Schultz J, Förster F
  (See online at https://doi.org/10.1093/molbev/msv174)
• Lifestyle evolution in cyanobacterial symbionts of sponges. MBio. 2015 Jun 2;6(3):e00391-15
  Burgsdorf I, Slaby BM, Handley KM, Haber M, Blom J, Marshall CW, Gilbert JA, Hentschel U, Steindler L
  (See online at https://doi.org/10.1128/mBio.00391-15)
• Megakaryocyte rupture for acute platelet needs. J Cell Biol. 2015 May 11;209(3):327-328
  Nieswandt B, Stritt S
  (See online at https://doi.org/10.1083/jcb.201504026)
• Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness. Nat Commun. 2015 Jan 9;6:5614
  Kmoch S, Majewski J, Ramamurthy V, Cao S, Fahiminiya S, Ren H, MacDonald IM, Lopez I, Sun V, Keser V, Khan A, Stránecký V, Hartmannová H, Přistoupilová A, Hodaňová K, Piherová L, Kuchař L, Baxová A, Chen R, Barsottini OG, Pyle A, Griffin H, Splitt M, Sallum J, Tolmie JL, Sampson JR, Chinnery P; Care4Rare Canada, Banin E, Sharon D, Dutta S, Grebler R, Helfrich-Foerster C, Pedroso JL, Kretzschmar D, Cayouette M, Koenekoop RK
  (See online at https://doi.org/10.1038/ncomms6614)
• Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice. Blood. 2015 Jan 8;125(2):219-22
  Stritt S, Wolf K, Lorenz V, Vögtle T, Gupta S, Bösl MR, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2014-08-597542)
• Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. Blood. 2015 Jun 25;125(26):4069-77
  Lorenz V, Stegner D, Stritt S, Vögtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B
  (See online at https://doi.org/10.1182/blood-2014-11-611905)
• A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. Blood. 2016 Jun 9;127(23):2903-14
  Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium BB, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD
  (See online at https://doi.org/10.1182/blood-2015-10-675629)
• A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development. Nat Commun. 2016 Jun 17;7:11841
  Klein-Hessling S, Rudolf R, Muhammad K, Knobeloch KP, Maqbool MA, Cauchy P, Andrau JC, Avots A, Talora C, Ellenrieder V, Screpanti I, Serfling E, Patra AK
  (See online at https://doi.org/10.1038/ncomms11841)
• BMC Biol. 2016 Mar 4;14:10
  Koziol U, Jarero F, Olson PD, Brehm K
  (See online at https://doi.org/10.1186/s12915-016-0233-x)
• Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. Nat Chem Biol. 2016 Aug;12(8):628-35
  Schulze A, Beliu G, Helmerich DA, Schubert J, Pearl LH, Prodromou C, Neuweiler H
  (See online at https://doi.org/10.1038/NCHEMBIO.2111)
• Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. Nat Chem Biol. 2016 Aug;12(8):628-35
  Schulze A, Beliu G, Helmerich DA, Schubert J, Pearl LH, Prodromou C, Neuweiler H
  (See online at https://doi.org/10.1038/NCHEMBIO.2111)
• Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Nat Commun. 2016 Mar 29;7:11097
  Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A
  (See online at https://doi.org/10.1038/ncomms11097)
• Different promoter affinities account for specificity in MYC-dependent gene regulation. Elife. 2016 Jul 27;5. pii: e15161
  Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E
  (See online at https://doi.org/10.7554/eLife.15161)
• Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling. Acta Neuropathol. 2016 Jul;132(1):93-110
  Yadav P, Selvaraj BT, Bender FL, Behringer M, Moradi M, Sivadasan R, Dombert B, Blum R, Asan E, Sauer M, Julien JP, Sendtner M
  (See online at https://doi.org/10.1007/s00401-016-1564-y)
• The CsrA-FliW network controls polar localization of the dual-function flagellin mRNA in Campylobacter jejuni. Nat Commun. 2016 May 27;7:11667
  Dugar G, Svensson SL, Bischler T, Wäldchen S, Reinhardt R, Sauer M, Sharma CM
  (See online at https://doi.org/10.1038/ncomms11667)
• The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1247-53
  van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B
  (See online at https://doi.org/10.1161/ATVBAHA.115.306883)
• The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs. Cell Rep. 2016 Sep 20;16(12):3103-12
  Paknia E, Chari A, Stark H, Fischer U
  (See online at https://doi.org/10.1016/j.celrep.2016.08.047)
• TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157
  Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B
  (See online at https://doi.org/10.1161/ATVBAHA.116.307727)
• Venus flytrap carnivorous lifestyle builds on herbivore defense strategies. Genome Res. 2016 Jun;26(6):812-25
  Bemm F, Becker D, Larisch C, Kreuzer I, Escalante-Perez M, Schulze WX, Ankenbrand M, Van de Weyer AL, Krol E, Al-Rasheid KA, Mithöfer A, Weber AP, Schultz J, Hedrich R
  (See online at https://doi.org/10.1101/gr.202200.115)
• Venus flytrap carnivorous lifestyle builds on herbivore defense strategies. Genome Res. 2016 Jun;26(6):812-25
  Bemm F, Becker D, Larisch C, Kreuzer I, Escalante-Perez M, Schulze WX, Ankenbrand M, Van de Weyer AL, Krol E, Al-Rasheid KA, Mithöfer A, Weber AP, Schultz J, Hedrich R
  (See online at https://doi.org/10.1101/gr.202200.115)
• A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nat Commun. 2017 Jun 15;8:15838
  Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B
  (See online at https://doi.org/10.1038/ncomms15838)
• Chlamydia preserves the mitochondrial network necessary for replication via microRNA- dependent inhibition of fission. J Cell Biol. 2017 Apr 3;216(4):1071-1089
  Chowdhury SR, Reimer A, Sharan M, Kozjak-Pavlovic V, Eulalio A, Prusty BK, Fraunholz M, Karunakaran K, Rudel T
  (See online at https://doi.org/10.1083/jcb.201608063)
• Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. Oncotarget. 2017 Dec 30;9(5):6518-6535
  Thakur C, Rapp UR, Rudel T
  (See online at https://doi.org/10.18632/oncotarget.23785)
• Diacylglycerol acyltransferase-mediated triacylglyerol synthesis augments basal thermotolerance. Plant Physiol. 2017 Sep;175(1):486-497
  Mueller SP, Unger M, Guender L, Fekete A, Mueller MJ
  (See online at https://doi.org/10.1104/pp.17.00861)
• Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors. Leukemia. 2017 Jan;31(1):186-194
  Monjezi R, Miskey C, Gogishvili T, Schleef M, Schmeer M, Einsele H, Ivics Z, Hudecek M
  (See online at https://doi.org/10.1038/leu.2016.180)
• Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus. PLoS Pathog. 2017 Nov 22;13(11):e1006728
  Mielich-Süss B, Wagner RM, Mietrach N, Hertlein T, Marincola G, Ohlsen K, Geibel S, Lopez D
  (See online at https://doi.org/10.1371/journal.ppat.1006728)
• Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation. J Cell Biol. 2017 Aug 7;216(8):2391-2407
  Prusty AB, Meduri R, Prusty BK, Vanselow J, Schlosser A, Fischer U
  (See online at https://doi.org/10.1083/jcb.201611108)
• Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation. J Cell Biol. 2017 Aug 7;216(8):2391-2407
  Prusty AB, Meduri R, Prusty BK, Vanselow J, Schlosser A, Fischer U
  (See online at https://doi.org/10.1083/jcb.201611108)
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