EXC 147:  Kardiopulmonales System

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 24676099

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Herz- und Lungenerkrankungen stellen weltweit die häufigsten Todesursachen mit hoher sozioökonomischer Belastung und immer noch unzureichenden Behandlungsmöglichkeiten dar. Der Exzellenz-Cluster Cardio-Pulmonales System (ECCPS), welcher die Universitäten in Frankfurt und Giessen und das Max-Planck Institut für Herz- und Lungenforschung in Bad Nauheim umfasst, vereinigt Grundlagenforschung mit klinischer Forschung auf folgenden Themengebieten: • Stamm/Progenitor-Zellen in kardio-pulmonaler Entwicklung, Organerhalt und Regeneration. • Vaskuläres und kardiales “Remodelling”, Entwicklung Remodelling-revertierender Therapien. • Angiogenese und Alveologenese in Physiologie, Regeneration und Reparatur. • Matrix-Homöostase und adaptive versus maladaptive mesenchymale Prozesse in der Fibrose. • Redox-abhängige Signaltransduktion und deren Beeinflussung in Hypoxie und Ischämie. • Integrität der vaskulären und alveolären Schranke bei Inflammation und Reparatur. • Schnittstelle zwischen dem endokrinen/metabolischen und dem vaskulären System. • Identifikation von Biomarkern und molekularen Signaturen für personalisierte Medizin. ECCPS-WissenschaftlerInnen haben zahlreiche grundlegende Beiträge zur Entwicklung der kardiopulmonalen Forschung geleistet, belegt durch hochrangige Publikationen und die Koordination großer nationaler und internationaler Forschungsverbünde. Insbesondere hervorzuheben ist die Übertragung innovativer Konzepte in die klinische Anwendung, dokumentiert durch erfolgreiche sowie laufende Phase II/III Studien und zahlreiche Patente. In ECCPS II wurden neue Forschungsansätze in alle genannten Themengebiete eingebracht (z.B. Epigenetik, Metabolomik, molekulare in-vivo Bildgebung) und eine neue Internationale Forschungsplattform mit dem Imperial College, London, und globalen Partnern zur Erforschung und Behandlung von pulmonal-vaskulären Erkrankungen mit hoher gesundheitlicher Bedeutung in Ländern der Dritten Welt gegründet. Zudem haben wir eine langfristig angelegte Technologieplattform eingerichtet, welche den Zugang aller ECCPS Fakultätsmitglieder zu neuesten Technologien sicherstellt (z.B. Bioinformatik, “omic“-Techniken, hochauflösende EXC147 Final Report Bildgebung). Zur Förderung des wissenschaftlichen Nachwuchses haben wir die ECCPS Akademie eingerichtet, um die erfolgreich laufenden Graduierten-Kollegs durch Postdoktoranden- und Programme der Karriereentwicklung zu komplettieren. Diese Maßnahmen haben den ECCPS in seiner Mission, die molekulare Pathogenese von vaskulären und parenchymatösen Herz- und Lungenerkrankungen zu entschlüsseln und neue für die personalisierte Medizin geeignete Therapiekonzepte zu entwickeln, wesentlich gestärkt.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1697279635

Projektbezogene Publikationen (Auswahl)

• Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation. Nat Med 12:235-39, 2006
  Fiedler, Ulrike; Reiss, Yvonne; Scharpfenecker, Marion; Grunow, Verena; Koidl, Stefanie; Thurston, Gavin; Gale, Nicholas W.; Witzenrath, Martin; Rosseau, Simone; Suttorp, Norbert; Sobke, Astrid; Herrmann, Matthias; Preissner, Klaus T.; Vajkoczy, Peter & A
  
• Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355:1210-21, 2006
  Schächinger, Volker; Erbs, Sandra; Elsässer, Albrecht; Haberbosch, Werner; Hambrecht, Rainer; Hölschermann, Hans; Yu, Jiangtao; Corti, Roberto; Mathey, Detlef G.; Hamm, Christian W.; Süselbeck, Tim; Assmus, Birgit; Tonn, Torsten; Dimmeler, Stefanie & Zeiher, Andreas M.
  
• Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355:1222-32, 2006
  Assmus, Birgit; Honold, Jörg; Schächinger, Volker; Britten, Martina B.; Fischer-Rasokat, Ulrich; Lehmann, Ralf; Teupe, Claudius; Pistorius, Katrin; Martin, Hans; Abolmaali, Nasreddin D.; Tonn, Torsten; Dimmeler, Stefanie & Zeiher, Andreas M.
  
• Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci USA 104:6388-93, 2007
  Kannemeier, Christian; Shibamiya, Aya; Nakazawa, Fumie; Trusheim, Heidi; Ruppert, Clemens; Markart, Philipp; Song, Yutong; Tzima, Eleni; Kennerknecht, Elisabeth; Niepmann, Michael; von Bruehl, Marie-Luise; Sedding, Daniel; Massberg, Steffen; Günther, Andreas; Engelmann, Bernd & Preissner, Klaus T.
  
• G12-G13-LARG-mediated signaling in vascular smooth muscle is required for saltinduced hypertension. Nat Med 14:64-68, 2008
  Wirth, Angela; Benyó, Zoltán; Lukasova, Martina; Leutgeb, Barbara; Wettschureck, Nina; Gorbey, Stefan; Örsy, Petra; Horváth, Béla; Maser-Gluth, Christiane; Greiner, Erich; Lemmer, Björn; Schütz, Günther; Gutkind, J. Silvio & Offermanns, Stefan
  
• SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21:2644-58, 2007
  Potente, Michael; Ghaeni, Laleh; Baldessari, Danila; Mostoslavsky, Raul; Rossig, Lothar; Dequiedt, Franck; Haendeler, Judith; Mione, Marina; Dejana, Elisabetta; Alt, Frederick W.; Zeiher, Andreas M. & Dimmeler, Stefanie
  
• An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 11:85-91, 2009
  Calzado, Marco A.; de la Vega, Laureano; Möller, Andreas; Bowtell, David D. L. & Schmitz, M. Lienhard
  
• Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflame cell recruitment. Science 322:1101-4, 2008
  Choi, Eun Young; Chavakis, Emmanouil; Czabanka, Marcus A.; Langer, Harald F.; Fraemohs, Line; Economopoulou, Matina; Kundu, Ramendra K.; Orlandi, Alessia; Zheng, Ying Yi; Prieto, DaRue A.; Ballantyne, Christie M.; Constant, Stephanie L.; Aird, William C.; Papayannopoulou, Thalia; Gahmberg, Carl G.; Udey, Mark C.; Vajkoczy, Peter; Quertermous, Thomas; Dimmeler, Stefanie; ... & Chavakis, Triantafyllos
  
• Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT–mediated clustering of CCR2. Cell Stem Cell 2:566-575, 2008
  Belema-Bedada, Fikru; Uchida, Shizuka; Martire, Alessandra; Kostin, Sawa & Braun, Thomas
  
• Lung epithelial apoptosis in influenza virus pneumonia: The role of macrophage expressed TNF- related apoptosis-inducing ligand. J Exp Med 205:3065-77, 2008
  Herold, Susanne; Steinmueller, Mirko; von Wulffen, Werner; Cakarova, Lidija; Pinto, Ruth; Pleschka, Stephan; Mack, Matthias; Kuziel, William A.; Corazza, Nadia; Brunner, Thomas; Seeger, Werner & Lohmeyer, Juergen
  
• Acquisition of the contractile phenotype of arterial smooth muscle cells depends on the miR- 143/145 gene cluster. J Clin Invest 119:2634-47, 2009
  Boettger, Thomas; Beetz, Nadine; Kostin, Sawa; Schneider, Johanna; Krüger, Marcus; Hein, Lutz & Braun, Thomas
  
• Anaphylactic shock depends on endothelial Gq/G11. J Exp Med 206:411-20, 2009
  Korhonen, Hanna; Fisslthaler, Beate; Moers, Alexandra; Wirth, Angela; Habermehl, Daniel; Wieland, Thomas; Schütz, Günther; Wettschureck, Nina; Fleming, Ingrid & Offermanns, Stefan
  
• Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med 206:2889-96, 2009
  Loot, Annemarieke E.; Schreiber, Judith G.; Fisslthaler, Beate & Fleming, Ingrid
  
• Epidermal growth factor-like 7 (EGFL7) modulates Notch signaling and effects neural stem cell renewal. Nat Cell Biol 11:873-80, 2009
  Schmidt, Mirko H.H.; Bicker, Frank; Nikolic, Iva; Meister, Jeannette; Babuke, Tanja; Picuric, Srdjan; Müller-Esterl, Werner; Plate, Karl H. & Dikic, Ivan
  
• MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324:1710-13, 2009
  Bonauer, Angelika; Carmona, Guillaume; Iwasaki, Masayoshi; Mione, Marina; Koyanagi, Masamichi; Fischer, Ariane; Burchfield, Jana; Fox, Henrik; Doebele, Carmen; Ohtani, Kisho; Chavakis, Emmanouil; Potente, Michael; Tjwa, Marc; Urbich, Carmen; Zeiher, Andreas M. & Dimmeler, Stefanie
  
• Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia. Circulation 119:1747-57, 2009
  Grünig, Ekkehard; Weissmann, Sylvia; Ehlken, Nicola; Fijalkowska, Anna; Fischer, Christine; Fourme, Thierry; Galié, Nazzareno; Ghofrani, Ardeschir; Harrison, Rachel E.; Huez, Sandrine; Humbert, Marc; Janssen, Bart; Kober, Jaroslaw; Koehler, Rolf; Machado, Rajiv D.; Mereles, Derliz; Naeije, Robert; Olschewski, Horst; Provencher, Steeve; ... & Seeger, Werner
  
• WNT1-inducible signalling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119:772-87, 2009
  Königshoff, Melanie; Kramer, Monika; Balsara, Nisha; Wilhelm, Jochen; Amarie, Oana Veronica; Jahn, Andreas; Rose, Frank; Fink, Ludger; Seeger, Werner; Schaefer, Liliana; Günther, Andreas & Eickelberg, Oliver
  
• An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab 11:311-19, 2010
  Ahmed, Kashan; Tunaru, Sorin; Tang, Cong; Müller, Michaela; Gille, Andreas; Sassmann, Antonia; Hanson, Julien & Offermanns, Stefan
  
• EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 65:487-91, 2010
  Sawamiphak, Suphansa; Seidel, Sascha; Essmann, Clara L.; Wilkinson, George A.; Pitulescu, Mara E.; Acker, Till & Acker-Palmer, Amparo
  
• Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome associated interstitial pneumonia. Am J Respir Crit Care Med 182:207-219, 2010
  Mahavadi, Poornima; Korfei, Martina; Henneke, Ingrid; Liebisch, Gerhard; Schmitz, Gerd; Gochuico, Bernadette R.; Markart, Philipp; Bellusci, Saverio; Seeger, Werner; Ruppert, Clemens & Guenther, Andreas
  
• The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120:4251-72, 2010
  Moreth, Kristin; Brodbeck, Rebekka; Babelova, Andrea; Gretz, Norbert; Spieker, Tilmann; Zeng-Brouwers, Jinyang; Pfeilschifter, Josef; Young, Marian F.; Schaefer, Roland M. & Schaefer, Liliana
  
• Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473: 234-8, 2011
  Guarani, Virginia; Deflorian, Gianluca; Franco, Claudio A.; Krüger, Marcus; Phng, Li-Kun; Bentley, Katie; Toussaint, Louise; Dequiedt, Franck; Mostoslavsky, Raul; Schmidt, Mirko H. H.; Zimmermann, Barbara; Brandes, Ralf P.; Mione, Marina; Westphal, Christoph H.; Braun, Thomas; Zeiher, Andreas M.; Gerhardt, Holger; Dimmeler, Stefanie & Potente, Michael
  
• Acute myocardial infarction activates progenitor cells and increases Wnt signaling in the bone marrow. Eur Heart J 33:1911-1919, 2012
  Assmus, B.; Iwasaki, M.; Schachinger, V.; Roexe, T.; Koyanagi, M.; Iekushi, K.; Xu, Q.; Tonn, T.; Seifried, E.; Liebner, S.; Kranert, W. T.; Grunwald, F.; Dimmeler, S. & Zeiher, A. M.
  
• cAMP phosphordiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. Circulation 123:1194-204, 2011
  Pullamsetti, Soni Savai; Savai, Rajkumar; Schaefer, Martina Barbara; Wilhelm, Jochen; Ghofrani, Hossein Ardeschir; Weissmann, Norbert; Schudt, Christian; Fleming, Ingrid; Mayer, Konstantin; Leiper, James; Seeger, Werner; Grimminger, Friedrich & Schermuly, Ralph Theo
  
• Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell 147:293-305, 2011
  Seimetz, Michael; Parajuli, Nirmal; Pichl, Alexandra; Veit, Florian; Kwapiszewska, Grazyna; Weisel, Friederike C.; Milger, Katrin; Egemnazarov, Bakytbek; Turowska, Agnieszka; Fuchs, Beate; Nikam, Sandeep; Roth, Markus; Sydykov, Akylbek; Medebach, Thomas; Klepetko, Walter; Jaksch, Peter; Dumitrascu, Rio; Garn, Holger; Voswinckel, Robert; ... & Weissmann, Norbert
  
• Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proc Natl Acad Sci USA 108:3276-81, 2011
  Boeckel, Jes-Niels; Guarani, Virginia; Koyanagi, Masamichi; Roexe, Tino; Lengeling, Andreas; Schermuly, Ralph T.; Gellert, Pascal; Braun, Thomas; Zeiher, Andreas & Dimmeler, Stefanie
  
• Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest 121:2470-9, 2011
  Clauss, Matthias; Voswinckel, Robert; Rajashekhar, Gangaraju; Sigua, Ninotchka L.; Fehrenbach, Heinz; Rush, Natalia I.; Schweitzer, Kelly S.; Yildirim, Ali Ö.; Kamocki, Krzysztof; Fisher, Amanda J.; Gu, Yuan; Safadi, Bilal; Nikam, Sandeep; Hubbard, Walter C.; Tuder, Rubin M.; Twigg, Homer L.; Presson, Robert G.; Sethi, Sanjay & Petrache, Irina
  
• MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res 109:1115-1119, 2011
  Boon, Reinier A.; Seeger, Timon; Heydt, Susanne; Fischer, Ariane; Hergenreider, Eduard; Horrevoets, Anton J.G.; Vinciguerra, Manlio; Rosenthal, Nadia; Sciacca, Sergio; Pilato, Michele; van Heijningen, Paula; Essers, Jeroen; Brandes, Ralf P.; Zeiher, Andreas M. & Dimmeler, Stefanie
  
• Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell 9:420-32, 2011
  Kubin, Thomas; Pöling, Jochen; Kostin, Sawa; Gajawada, Praveen; Hein, Stefan; Rees, Wolfgang; Wietelmann, Astrid; Tanaka, Minoru; Lörchner, Holger; Schimanski, Silvia; Szibor, Marten; Warnecke, Henning & Braun, Thomas
  
• Transcoronary concentration gradients of circulating microRNAs. Circulation 124:1936-44, 2011
  De Rosa, Salvatore; Fichtlscherer, Stephan; Lehmann, Ralf; Assmus, Birgit; Dimmeler, Stefanie & Zeiher, Andreas M.
  
• A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell 46:472-483, 2012
  de la Vega, Laureano; Grishina, Inna; Moreno, Rita; Krüger, Marcus; Braun, Thomas & Schmitz, M. Lienhard
  
• Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest 122:3652-3664, 2012
  Unkel, Barbara; Hoegner, Katrin; Clausen, Björn E.; Lewe-Schlosser, Peter; Bodner, Johannes; Gattenloehner, Stefan; Janßen, Hermann; Seeger, Werner; Lohmeyer, Juergen & Herold, Susanne
  
• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nature Cell Biol 14:249-256, 2012
  Hergenreider, Eduard; Heydt, Susanne; Tréguer, Karine; Boettger, Thomas; Horrevoets, Anton J. G.; Zeiher, Andreas M.; Scheffer, Margot P.; Frangakis, Achilleas S.; Yin, Xiaoke; Mayr, Manuel; Braun, Thomas; Urbich, Carmen; Boon, Reinier A. & Dimmeler, Stefanie
  
• Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 186:897-908, 2012
  Savai, Rajkumar; Pullamsetti, Soni S.; Kolbe, Julia; Bieniek, Ewa; Voswinckel, Robert; Fink, Ludger; Scheed, Axel; Ritter, Christin; Dahal, Bhola K.; Vater, Axel; Klussmann, Sven; Ghofrani, Hossein A.; Weissmann, Norbert; Klepetko, Walter; Banat, Gamal A.; Seeger, Werner; Grimminger, Friedrich & Schermuly, Ralph T.
  
• Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res 110:1217-1225, 2012
  Schröder, Katrin; Zhang, Min; Benkhoff, Sebastian; Mieth, Anja; Pliquett, Rainer; Kosowski, Judith; Kruse, Christoph; Luedike, Peter; Michaelis, U. Ruth; Weissmann, Norbert; Dimmeler, Stefanie; Shah, Ajay M. & Brandes, Ralf P.
  
• Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med 209:2277-2290, 2012
  Althoff, Till F.; Juárez, Julián Albarrán; Troidl, Kerstin; Tang, Cong; Wang, Shengpeng; Wirth, Angela; Takefuji, Mikito; Wettschureck, Nina & Offermanns, Stefan
  
• Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction. Circulation 125:1765-73, 2012
  Iekushi, Kazuma; Seeger, Florian; Assmus, Birgit; Zeiher, Andreas M. & Dimmeler, Stefanie
  
• Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. Am J Respir Crit Care Med 188: 1451-1459, 2013
  Malczyk, Monika; Veith, Christine; Fuchs, Beate; Hofmann, Katharina; Storch, Ursula; Schermuly, Ralph T.; Witzenrath, Martin; Ahlbrecht, Katrin; Fecher-Trost, Claudia; Flockerzi, Veit; Ghofrani, Hossein A.; Grimminger, Friedrich; Seeger, Werner; Gudermann, Thomas; Dietrich, Alexander & Weissmann, Norbert
  
• Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELL- WAVE randomized clinical trial. J Am Med Assoc 309:1622-1631, 2013
  Assmus, Birgit; Walter, Dirk H.; Seeger, Florian H.; Leistner, David M.; Steiner, Julia; Ziegler, Ina; Lutz, Andreas; Khaled, Walaa; Klotsche, Jens; Tonn, Torsten; Dimmeler, Stefanie & Zeiher, Andreas M.
  
• G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 25:427-434, 2013
  Sivaraj, Kishor Kumar; Takefuji, Mikito; Schmidt, Inga; Adams, Ralf H.; Offermanns, Stefan & Wettschureck, Nina
  
• Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation 127:1128-1138, 2013
  Hoeper, Marius M.; Barst, Robyn J.; Bourge, Robert C.; Feldman, Jeremy; Frost, Adaani E.; Galié, Nazzareno; Gómez-Sánchez, Miguel Angel; Grimminger, Friedrich; Grünig, Ekkehard; Hassoun, Paul M.; Morrell, Nicholas W.; Peacock, Andrew J.; Satoh, Toru; Simonneau, Gérald; Tapson, Victor F.; Torres, Fernando; Lawrence, David; Quinn, Deborah A. & Ghofrani, Hossein-Ardeschir
  
• Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. Circulation 128:1066-1075, 2013
  Hinkel, Rabea; Penzkofer, Daniela; Zühlke, Stefanie; Fischer, Ariane; Husada, Wira; Xu, Quan-Fu; Baloch, Elisabeth; van Rooij, Eva; Zeiher, Andreas M.; Kupatt, Christian & Dimmeler, Stefanie
  
• Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia. PLoS Pathog 9:e1003188, 2013
  Högner, Katrin; Wolff, Thorsten; Pleschka, Stephan; Plog, Stephanie; Gruber, Achim D.; Kalinke, Ulrich; Walmrath, Hans-Dieter; Bodner, Johannes; Gattenlöhner, Stefan; Lewe-Schlosser, Peter; Matrosovich, Mikhail; Seeger, Werner; Lohmeyer, Juergen & Herold, Susanne
  
• MicroRNA-223 antagonizes angiogenesis by targeting β1 integrin and preventing growth factor signaling in endothelial cells. Circ Res 113:1320-1330, 2013
  Shi, Lei; Fisslthaler, Beate; Zippel, Nina; Frömel, Timo; Hu, Jiong; Elgheznawy, Amro; Heide, Heinrich; Popp, Rüdiger & Fleming, Ingrid
  
• MicroRNA-34a regulates cardiac ageing and function. Nature 495:107-110, 2013
  Boon, Reinier A.; Iekushi, Kazuma; Lechner, Stefanie; Seeger, Timon; Fischer, Ariane; Heydt, Susanne; Kaluza, David; Tréguer, Karine; Carmona, Guillaume; Bonauer, Angelika; Horrevoets, Anton J. G.; Didier, Nathalie; Girmatsion, Zenawit; Biliczki, Peter; Ehrlich, Joachim R.; Katus, Hugo A.; Müller, Oliver J.; Potente, Michael; Zeiher, Andreas M.; ... & Dimmeler, Stefanie
  
• Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell 13:590-601, 2013
  Günther, Stefan; Kim, Johnny; Kostin, Sawa; Lepper, Christoph; Fan, Chen-Ming & Braun, Thomas
  
• NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest. 123:4731-4738, 2013
  Goettsch, Claudia; Babelova, Andrea; Trummer, Olivia; Erben, Reinhold G.; Rauner, Martina; Rammelt, Stefan; Weissmann, Norbert; Weinberger, Valeska; Benkhoff, Sebastian; Kampschulte, Marian; Obermayer-Pietsch, Barbara; Hofbauer, Lorenz C.; Brandes, Ralf P. & Schröder, Katrin
  
• Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24:130-137, 2013
  Schumacher, Dagmar; Strilic, Boris; Sivaraj, Kishor Kumar; Wettschureck, Nina & Offermanns, Stefan
  
• RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J Exp Med 210: 665-673, 2013
  Takefuji, Mikito; Krüger, Marcus; Sivaraj, Kishor K.; Kaibuchi, Kozo; Offermanns, Stefan & Wettschureck, Nina
  
• Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med 369:319-329, 2013
  Ghofrani, Hossein-Ardeschir; D'Armini, Andrea M.; Grimminger, Friedrich; Hoeper, Marius M.; Jansa, Pavel; Kim, Nick H.; Mayer, Eckhard; Simonneau, Gerald; Wilkins, Martin R.; Fritsch, Arno; Neuser, Dieter; Weimann, Gerrit & Wang, Chen
  
• Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med 369:330-340, 2013
  Ghofrani, Hossein-Ardeschir; Galiè, Nazzareno; Grimminger, Friedrich; Grünig, Ekkehard; Humbert, Marc; Jing, Zhi-Cheng; Keogh, Anne M.; Langleben, David; Kilama, Michael Ochan; Fritsch, Arno; Neuser, Dieter & Rubin, Lewis J.
  
• The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res 112:924-934, 2013
  Michaelis, U. Ruth; Chavakis, Emmanouil; Kruse, Christoph; Jungblut, Benno; Kaluza, David; Wandzioch, Katalin; Manavski, Yosif; Heide, Heinrich; Santoni, Marie-Josée; Potente, Michael; Eble, Johannes A.; Borg, Jean-Paul & Brandes, Ralf P.
  
• glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med 211:281-295, 2014
  Hu, Jiong; Popp, Rüdiger; Frömel, Timo; Ehling, Manuel; Awwad, Khader; Adams, Ralf H.; Hammes, Hans-Peter & Fleming, Ingrid
  
• Inhaled granulocyte/macrophage colony-stimulating factor as treatment of pneumonia-associated acute respiratory distress syndrome. Am J Respir Crit Care Med 189:609-611, 2014
  Herold, Susanne; Hoegner, Katrin; Vadász, István; Gessler, Tobias; Wilhelm, Jochen; Mayer, Konstantin; Morty, Rory E.; Walmrath, Hans-Dieter; Seeger, Werner & Lohmeyer, Juergen
  
• Long-term clinical outcome after intracoronary application of bone marrow-derived mononuclear cells for acute myocardial infarction: Migratory capacity of administered cells determines event-free survival. Eur Heart J 35:1275-1283, 2014
  Assmus, Birgit; Leistner, David M.; Schächinger, Volker; Erbs, Sandra; Elsässer, Albrecht; Haberbosch, Werner; Hambrecht, Rainer; Sedding, Daniel; Yu, Jiangtao; Corti, Roberto; Mathey, Detlef G.; Barth, Christine; Mayer-Wehrstein, Charlotte; Burck, Iris; Sueselbeck, Tim; Dill, Thorsten; Hamm, Christian W.; Tonn, Torsten; Dimmeler, Stefanie; ... & Palapies, Lars
  
• Prehospital ticagrelor in ST-segment elevation myocardial infarction. N Engl J Med. 371:1016-27, 2014
  Montalescot, Gilles; van 't Hof, Arnoud W.; Lapostolle, Frédéric; Silvain, Johanne; Lassen, Jens Flensted; Bolognese, Leonardo; Cantor, Warren J.; Cequier, Ángel; Chettibi, Mohamed; Goodman, Shaun G.; Hammett, Christopher J.; Huber, Kurt; Janzon, Magnus; Merkely, Béla; Storey, Robert F.; Zeymer, Uwe; Stibbe, Olivier; Ecollan, Patrick; Heutz, Wim M.J.M.; ... & Hamm, Christian W.
  
• Proproliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension. Nature Med 20:1289-1300, 2014
  Savai, Rajkumar; Al-Tamari, Hamza M; Sedding, Daniel; Kojonazarov, Baktybek; Muecke, Christian; Teske, Rebecca; Capecchi, Mario R; Weissmann, Norbert; Grimminger, Friedrich; Seeger, Werner; Schermuly, Ralph Theo & Pullamsetti, Soni Savai
  
• RBM24 is a major regulator of muscle-specific alternative splicing. Dev Cell 31:87-99, 2014
  Yang, Jiwen; Hung, Lee-Hsueh; Licht, Thomas; Kostin, Sawa; Looso, Mario; Khrameeva, Ekaterina; Bindereif, Albrecht; Schneider, Andre & Braun, Thomas
  
• Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema. Am J Respir Crit Care Med 189: 1359-1373, 2014
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