Generation of specificity in post-Golgi trafficking (A01)

• Subject Area: Plant Cell and Developmental Biology
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 232631280

In Arabidopsis membrane traffic, specific coat proteins are recruited by ARF1 GTPase activated by different pathway-specific ARF-GEFs. Although ARF-GEF GNOM and its closely related paralogue GNL1 use the same domain interaction required for membrane association, only GNOM – but not GNL1 – mediates endosomal recycling. We will continue to analyse the structural basis for the functional specificity of GNOM, the mechanisms of its endosomal membrane association and the pathway-specific recruitment of coat protein complexes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1101: Molecular Encoding of Specificity in Plant Processes
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Head: Professor Dr. Gerd Jürgens