Proteine des humanpathogenen Malariaerregers Plasmodium falciparum als Zielstrukturen in der Malariatherapie

• Antragstellerin: Professorin Dr. Gabriele Pradel
• Fachliche Zuordnung: Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
• Förderung: Förderung von 2013 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 248381495

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cellular Microbiology, Vol. 16. 2014, Issue 5: Special Issue: Malaria, pp. 709-733.
  Wirth C.C., Glushakova S., Scheuermayer M., Repnik U., Garg S., Schaack D., Kachman M.M., Weißbach T., Zimmerberg J., Dandekar T., Griffiths G., Chitnis C.E., Singh S., Fischer R., Pradel G.
  
• A WD40-repeat protein unique to malaria parasites associates with adhesion protein complexes and is crucial for blood stage progeny. Malaria Journal, Vol. 14. 2015, Article number: 435.
  von Bohl A., Kuehn A., Simon N., Ngongang V.N., Spehr M., Baumeister S., Przyborski J.M., Fischer R., Pradel G.
  
• Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum. Molecular and Biochemical Parasitology, Vol. 201. 2015, Issue 2, pp. 90-99.
  Wirth C.C., Bennink S., Scheuermayer M., Fischer R., Pradel G.
  
• Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes. Cell Host Microbe, Vol. 20, Issue 5, pp. 618-630.
  Bargieri D.Y., Thiberge S., Tay C.L., Carey A.F., Rantz A., Hischen F., Lorthiois A., Straschil U., Singh P., Singh S., Triglia T., Tsuboi T., Cowman A., Chitnis C., Alano P., Baum J., Pradel G., Lavazec C., Ménard R.
  
• The development of malaria parasites in the mosquito midgut. Cellular Microbiology, Vol. 18 2016, Issue 7, pp. 905-918.
  Bennink S., Kiesow M.J., Pradel G.
  
• The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cellular Microbiology, Vol. 18. 2016, Issue 4, pp. 573-590,
  Rosa T.F.A., Flammersfeld A., Ngwa C.J., Kiesow M., Fischer R., Zipfel P.F., Skerka C., Pradel G.
  
• Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Frontiers in Cellular and Infection Microbiology, Vol. 7. 2017, 320.
  Ngwa C.J., Kiesow M.J., Papst O., Orchard L.M., Filarsky M., Rosinski A.N., Voss T.S., Llinás M., Pradel G.
  
• A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum. PLOS Pathogens, Vol. 14. 2018, Issue 8: e1007249.
  Bennink S., von Bohl A., Ngwa C.J., Henschel L., Kuehn A., Pilch N., Weißbach T., Rosinski A.N., Scheuermayer M., Repnik U., Przyborski J.M., Minns A.M., Orchard L.M., Griffiths G., Lindner S.E., Llinás M., Pradel G.
  
• Cutting Edge: FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. Journal of Immunology, Vol. 201. 2018, Issue 12, pp. 3497-3502.
  Reiss T., Rosa T.F.A., Blaesius K., Bobbert R.P., Zipfel P.F., Skerka C., Pradel G.
  
• Pathways of host cell exit by intracellular pathogens. Microbial Cell, Vol. 5. 2018, No. 12, pp. 525 - 544
  Flieger A., Frischknecht F., Häcker G., Hornef M.W., Pradel G.