Proteins of the human malaria parasite Plasmodium falciparum as targets in malaria therapy

• Applicant: Professorin Dr. Gabriele Pradel
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2013 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 248381495

• Final Report Year: 2019

No abstract available

Publications

• Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cellular Microbiology, Vol. 16. 2014, Issue 5: Special Issue: Malaria, pp. 709-733.
  Wirth, Christine C.; Glushakova, Svetlana; Scheuermayer, Matthias; Repnik, Urska; Garg, Swati; Schaack, Dominik; Kachman, Marika M.; Weißbach, Tim; Zimmerberg, Joshua; Dandekar, Thomas; Griffiths, Gareth; Chitnis, Chetan E.; Singh, Shailja; Fischer, Rainer & Pradel, Gabriele
  
• A WD40-repeat protein unique to malaria parasites associates with adhesion protein complexes and is crucial for blood stage progeny. Malaria Journal, Vol. 14. 2015, Article number: 435.
  von Bohl, Andreas; Kuehn, Andrea; Simon, Nina; Ngongang, Vanesa Nkwouano; Spehr, Marc; Baumeister, Stefan; Przyborski, Jude M.; Fischer, Rainer & Pradel, Gabriele
  
• Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum. Molecular and Biochemical Parasitology, Vol. 201. 2015, Issue 2, pp. 90-99.
  Wirth, Christine C.; Bennink, Sandra; Scheuermayer, Matthias; Fischer, Rainer & Pradel, Gabriele
  
• The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cellular Microbiology, Vol. 18. 2016, Issue 4, pp. 573-590,
  Rosa, Thiago F. A.; Flammersfeld, Ansgar; Ngwa, Che J.; Kiesow, Meike; Fischer, Rainer; Zipfel, Peter F.; Skerka, Christine & Pradel, Gabriele
  
• Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes. Cell Host Microbe, Vol. 20, Issue 5, pp. 618-630.
  Bargieri, Daniel Y.; Thiberge, Sabine; Tay, Chwen L.; Carey, Alison F.; Rantz, Alice; Hischen, Florian; Lorthiois, Audrey; Straschil, Ursula; Singh, Pallavi; Singh, Shailja; Triglia, Tony; Tsuboi, Takafumi; Cowman, Alan; Chitnis, Chetan; Alano, Pietro; Baum, Jake; Pradel, Gabriele; Lavazec, Catherine & Ménard, Robert
  
• The development of malaria parasites in the mosquito midgut. Cellular Microbiology, Vol. 18 2016, Issue 7, pp. 905-918.
  Bennink, Sandra; Kiesow, Meike J. & Pradel, Gabriele
  
• Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Frontiers in Cellular and Infection Microbiology, Vol. 7. 2017, 320.
  Ngwa, Che J.; Kiesow, Meike J.; Papst, Olga; Orchard, Lindsey M.; Filarsky, Michael; Rosinski, Alina N.; Voss, Till S.; Llinás, Manuel & Pradel, Gabriele
  
• A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum. PLOS Pathogens, Vol. 14. 2018, Issue 8: e1007249.
  Bennink, Sandra; von Bohl, Andreas; Ngwa, Che J.; Henschel, Leonie; Kuehn, Andrea; Pilch, Nicole; Weißbach, Tim; Rosinski, Alina N.; Scheuermayer, Matthias; Repnik, Urska; Przyborski, Jude M.; Minns, Allen M.; Orchard, Lindsey M.; Griffiths, Gareth; Lindner, Scott E.; Llinás, Manuel & Pradel, Gabriele
  
• Cutting Edge: FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. Journal of Immunology, Vol. 201. 2018, Issue 12, pp. 3497-3502.
  Reiss, Timo; Rosa, Thiago F. de A.; Blaesius, Katharina; Bobbert, Rebecca P.; Zipfel, Peter F.; Skerka, Christine & Pradel, Gabriele
  
• Pathways of host cell exit by intracellular pathogens. Microbial Cell, Vol. 5. 2018, No. 12, pp. 525 - 544
  Flieger, Antje; Frischknecht, Freddy; Haecker, Georg; Hornef, Mathias W. & Pradel, Gabriele