Proteins of the human malaria parasite Plasmodium falciparum as targets in malaria therapy

• Applicant: Professorin Dr. Gabriele Pradel
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2013 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 248381495

• Final Report Year: 2019

Final Report Abstract

No abstract available

Publications

• Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cellular Microbiology, Vol. 16. 2014, Issue 5: Special Issue: Malaria, pp. 709-733.
  Wirth C.C., Glushakova S., Scheuermayer M., Repnik U., Garg S., Schaack D., Kachman M.M., Weißbach T., Zimmerberg J., Dandekar T., Griffiths G., Chitnis C.E., Singh S., Fischer R., Pradel G.
  (See online at https://doi.org/10.1111/cmi.12288)
• A WD40-repeat protein unique to malaria parasites associates with adhesion protein complexes and is crucial for blood stage progeny. Malaria Journal, Vol. 14. 2015, Article number: 435.
  von Bohl A., Kuehn A., Simon N., Ngongang V.N., Spehr M., Baumeister S., Przyborski J.M., Fischer R., Pradel G.
  (See online at https://doi.org/10.1186/s12936-015-0967-x)
• Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum. Molecular and Biochemical Parasitology, Vol. 201. 2015, Issue 2, pp. 90-99.
  Wirth C.C., Bennink S., Scheuermayer M., Fischer R., Pradel G.
  (See online at https://doi.org/10.1016/j.molbiopara.2015.06.005)
• Plasmodium merozoite TRAP family protein is essential for vacuole membrane disruption and gamete egress from erythrocytes. Cell Host Microbe, Vol. 20, Issue 5, pp. 618-630.
  Bargieri D.Y., Thiberge S., Tay C.L., Carey A.F., Rantz A., Hischen F., Lorthiois A., Straschil U., Singh P., Singh S., Triglia T., Tsuboi T., Cowman A., Chitnis C., Alano P., Baum J., Pradel G., Lavazec C., Ménard R.
  (See online at https://doi.org/10.1016/j.chom.2016.10.015)
• The development of malaria parasites in the mosquito midgut. Cellular Microbiology, Vol. 18 2016, Issue 7, pp. 905-918.
  Bennink S., Kiesow M.J., Pradel G.
  (See online at https://doi.org/10.1111/cmi.12604)
• The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cellular Microbiology, Vol. 18. 2016, Issue 4, pp. 573-590,
  Rosa T.F.A., Flammersfeld A., Ngwa C.J., Kiesow M., Fischer R., Zipfel P.F., Skerka C., Pradel G.
  (See online at https://doi.org/10.1111/cmi.12535)
• Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Frontiers in Cellular and Infection Microbiology, Vol. 7. 2017, 320.
  Ngwa C.J., Kiesow M.J., Papst O., Orchard L.M., Filarsky M., Rosinski A.N., Voss T.S., Llinás M., Pradel G.
  (See online at https://doi.org/10.3389/fcimb.2017.00320)
• A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum. PLOS Pathogens, Vol. 14. 2018, Issue 8: e1007249.
  Bennink S., von Bohl A., Ngwa C.J., Henschel L., Kuehn A., Pilch N., Weißbach T., Rosinski A.N., Scheuermayer M., Repnik U., Przyborski J.M., Minns A.M., Orchard L.M., Griffiths G., Lindner S.E., Llinás M., Pradel G.
  (See online at https://doi.org/10.1371/journal.ppat.1007249)
• Cutting Edge: FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. Journal of Immunology, Vol. 201. 2018, Issue 12, pp. 3497-3502.
  Reiss T., Rosa T.F.A., Blaesius K., Bobbert R.P., Zipfel P.F., Skerka C., Pradel G.
  (See online at https://doi.org/10.4049/jimmunol.1800662)
• Pathways of host cell exit by intracellular pathogens. Microbial Cell, Vol. 5. 2018, No. 12, pp. 525 - 544
  Flieger A., Frischknecht F., Häcker G., Hornef M.W., Pradel G.
  (See online at https://doi.org/10.15698/mic2018.12.659)