Oxidative stress: enzymatic detoxification of reactive carbonyl compounds in simple model organisms and man

Applicant Professor Dr. Edmund Maser

Subject Area Public Health, Healthcare Research, Social and Occupational Medicine

Term from 2014 to 2018

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 248793591

Final Report Year 2017

Final Report Abstract

No abstract available

(2018) Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans. The FEBS journal 285 (2) 275–293
Kisiela, Michael; Faust, Annette; Ebert, Bettina; Maser, Edmund; Scheidig, Axel J.
(See online at https://doi.org/10.1111/febs.14337)
(2015) Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase - Carbonyl reductase 1. Chem Biol Interact 234:162-168
Hintzpeter J, Hornung J, Ebert B, Martin HJ, and Maser E
(See online at https://doi.org/10.1016/j.cbi.2014.12.019)
(2016). Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) –An in silico approach. Drug metabolism reviews 48, 183-217
Bettina Ebert, Michael Kisiela and Edmund Maser
(See online at https://doi.org/10.3109/03602532.2016.1167902)