Kortikale Netzwerkstörungen durch Hyperstimulierung des Neuregulin/ErbB4-Signalwegs

• Antragsteller: Privatdozent Dr. Markus Hermann Schwab
• Fachliche Zuordnung: Molekulare Biologie und Physiologie von Nerven- und Gliazellen
• Förderung: Förderung von 2014 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 249113022

• Erstellungsjahr: 2019

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell Reports, Vol. 8. 2014, Issue 4, pp. 1130-1145.
  Agarwal, Amit; Zhang, Mingyue; Trembak-Duff, Irina; Unterbarnscheidt, Tilmann; Radyushkin, Konstantin; Dibaj, Payam; Martins de Souza, Daniel; Boretius, Susann; Brzózka, Magdalena M.; Steffens, Heinz; Berning, Sebastian; Teng, Zenghui; Gummert, Maike N.; Tantra, Martesa; Guest, Peter C.; Willig, Katrin I.; Frahm, Jens; Hell, Stefan W.; Bahn, Sabine; ... & Schwab, Markus H.
  
• Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated Synapse elimination at developing neuromuscular junctions. Proceedings of the National Academy of Sciences of the USA, Vol. 113. 2016, Issue 4, pp. E479-E487.
  Lee, Young il; Li, Yue; Mikesh, Michelle; Smith, Ian; Nave, Klaus-Armin; Schwab, Markus H. & Thompson, Wesley J.
  
• OSO paradigm-A rapid behavioral screening method for acute psychosocial stress reactivity in mice. Neuroscience, Vol. 314. 2016, pp. 1-11.
  Brzózka, M.M.; Unterbarnscheidt, T.; Schwab, M.H. & Rossner, M.J.
  
• Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. EMBO Molecular Medicine, Vol. 9. 2017, Issue 10, pp. 1448-1462.
  Wehr, Michael C.; Hinrichs, Wilko; Brzózka, Magdalena M.; Unterbarnscheidt, Tilmann; Herholt, Alexander; Wintgens, Jan P.; Papiol, Sergi; Soto‐bernardini, Maria Clara; Kravchenko, Mykola; Zhang, Mingyue; Nave, Klaus‐Armin; Wichert, Sven P.; Falkai, Peter;
  
• Altered hippocampal gene expression and structure in transgenic mice over-expressing neuregulin 1 (NRG1) type I. Translational Psychiatry, Vol. 8. 2018, Article number: 229.
  Deakin, Inga H.; Godlewska, Beata R.; Walker, Mary A.; Huang, Guo-Jen; Schwab, Markus H.; Nave, Klaus-Armin; Law, Amanda J. & Harrison, Paul J.
  
• Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair. FASEB Journal, Vol. 33. 2019, No. 7, pp. 7833-7851.
  Salvany, Sara; Casanovas, Anna; Tarabal, Olga; Piedrafita, Lídia; Hernández, Sara; Santafé, Manuel; Soto-Bernardini, María Clara; Calderó, Jordi; Schwab, Markus H. & Esquerda, Josep E.
  
• NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies. Nature Communications, Vol. 10. 2019, Article number: 1467.
  Fledrich, Robert; Akkermann, Dagmar; Schütza, Vlad; Abdelaal, Tamer A.; Hermes, Doris; Schäffner, Erik; Soto-Bernardini, M. Clara; Götze, Tilmann; Klink, Axel; Kusch, Kathrin; Krueger, Martin; Kungl, Theresa; Frydrychowicz, Clara; Möbius, Wiebke; Brück, Wolfgang; Mueller, Wolf C.; Bechmann, Ingo; Sereda, Michael W.; Schwab, Markus H.; ... & Stassart, Ruth M.