Kontrolle von Zytokinantworten durch das Transkriptionsfaktornetzwerk MITF-IRF4 beim malignen Melanom

• Antragsteller: Professor Dr. Michael Hölzel
• Fachliche Zuordnung: Dermatologie ; Hämatologie, Onkologie
• Förderung: Förderung von 2013 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 251103840

• Erstellungsjahr: 2021

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov. 4, 674–687 (2014).5
  Bald, Tobias; Landsberg, Jennifer; Lopez-Ramos, Dorys; Renn, Marcel; Glodde, Nicole; Jansen, Philipp; Gaffal, Evelyn; Steitz, Julia; Tolba, Rene; Kalinke, Ulrich; Limmer, Andreas; Jönsson, Göran; Hölzel, Michael & Tüting, Thomas
  
• Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature. 2014 Mar 6;507(7490):109-13
  Bald, Tobias; Quast, Thomas; Landsberg, Jennifer; Rogava, Meri; Glodde, Nicole; Lopez-Ramos, Dorys; Kohlmeyer, Judith; Riesenberg, Stefanie; van den Boorn-Konijnenberg, Debby; Hömig-Hölzel, Cornelia; Reuten, Raphael; Schadow, Benjamin; Weighardt, Heike; Wenzel, Daniela; Helfrich, Iris; Schadendorf, Dirk; Bloch, Wilhelm; Bianchi, Marco E.; Lugassy, Claire; ... & Tüting, Thomas
  
• MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nature Communications 2015;6:8755.2
  Riesenberg, Stefanie; Groetchen, Angela; Siddaway, Robert; Bald, Tobias; Reinhardt, Julia; Smorra, Denise; Kohlmeyer, Judith; Renn, Marcel; Phung, Bengt; Aymans, Pia; Schmidt, Tobias; Hornung, Veit; Davidson, Irwin; Goding, Colin R.; Jönsson, Göran; Landsberg, Jennifer; Tüting, Thomas & Hölzel, Michael
  
• A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells. Cancer Research 2016;76(2):251–263.6
  Hölzel, Michael; Landsberg, Jennifer; Glodde, Nicole; Bald, Tobias; Rogava, Meri; Riesenberg, Stefanie; Becker, Albert; Jönsson, Göran & Tüting, Thomas
  
• Inflammation-Induced Plasticity in Melanoma Therapy and Metastasis. Trends Immunol. 2016 Jun;37(6):364-374.9
  Hölzel, Michael & Tüting, Thomas
  
• MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Cancer Research 2017;77(17):4697–4709.3
  Reinhardt, Julia; Landsberg, Jennifer; Schmid-Burgk, Jonathan L.; Ramis, Bartomeu Bibiloni; Bald, Tobias; Glodde, Nicole; Lopez-Ramos, Dorys; Young, Arabella; Ngiow, Shin Foong; Nettersheim, Daniel; Schorle, Hubert; Quast, Thomas; Kolanus, Waldemar; Schadendorf, Dirk; Long, Georgina V.; Madore, Jason; Scolyer, Richard A.; Ribas, Antoni; Smyth, Mark J.; ... & Hölzel, Michael
  
• Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. Immunity 2017;47(4):789-802.e9
  Glodde, Nicole; Bald, Tobias; van den Boorn-Konijnenberg, Debby; Nakamura, Kyohei; O’Donnell, Jake S.; Szczepanski, Sabrina; Brandes, Maria; Eickhoff, Sarah; Das, Indrajit; Shridhar, Naveen; Hinze, Daniel; Rogava, Meri; van der Sluis, Tetje C.; Ruotsalainen, Janne J.; Gaffal, Evelyn; Landsberg, Jennifer; Ludwig, Kerstin U.; Wilhelm, Christoph; Riek-Burchardt, Monika; ... & Hölzel, Michael
  
• Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. Genes & Develompent 2017;31(1):18–33.7
  Falletta, Paola; Sanchez-del-Campo, Luis; Chauhan, Jagat; Effern, Maike; Kenyon, Amy; Kershaw, Christopher J.; Siddaway, Robert; Lisle, Richard; Freter, Rasmus; Daniels, Matthew J.; Lu, Xin; Tüting, Thomas; Middleton, Mark; Buffa, Francesca M.; Willis, Anne E.; Pavitt, Graham; Ronai, Ze'ev A.; Sauka-Spengler, Tatjana; Hölzel, Michael; ... & Goding, Colin R.