Regulation of T cell plasticity and metabolism by coagulation regulators (B26)

• Subject Area: Immunology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

Within the 2nd funding period, project B26 established that coagulation protease activated protein C (aPC) acts directly on primary T cells via the receptor-heterodimer PAR2/PAR3, promoting expansion of Tregs and protecting from GvHD (graft versus host disease; cooperation with A05, Z01). Within the 3rd funding period we will investigate specific candidate receptors (e.g. integrins, S1PR1, cooperation with A20, B12), the metabolic signature, and signaling pathways (cooperation with A04, A23, B14, B16, B19). Furthermore, the relevance of platelets for the coagulation protease aPC-dependent effect on T cells will be investigated, focusing on mechanistic studies related to platelet-derived extracellular vesicles, ATP/ADP and potentially involved receptors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Head: Professor Dr. Berend Isermann