Interleukin-22 in kidney regeneration
Final Report Abstract
The project turned out to be quite successful in terms of generating new and in part unexpected insights in the biology of IL-22 in the kidney. To my best knowledge, we were the only ones in the world working on this topic and could come up with a bunch of new concepts following our initial paper published in J Am Soc Nephrol on IL-22 in acute kidney injury. We explored kidney regeneration, chronic progressive kidney atrophy, and renal cancer, just to name a few. As the most exciting result we identified IL-22R expression as a prognostic biomarker for clear cell RCC and raised a rationale also for using IL-22 blockade as a sensitizer for cytotoxic therapies. If there is a role for this in the current phase of check point inhibitors remains to be seen.
Publications
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Interleukin-22 in kidney injury and regeneration. Am J Physiol Renal Physiol. 2015 May 15;308(10):F1041-6
Weidenbusch, Marc; Rodler, Severin & Anders, Hans-Joachim
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Links between coagulation, inflammation, regeneration, and fibrosis in kidney pathology. Lab Invest. 2016 Apr; 96(4):378-90.2015.164
Suárez-Álvarez, Beatriz; Liapis, Helen & Anders, Hans-Joachim
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Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease. J Am Soc Nephrol. 2016 Sep;27(9):2564-75
Anders, Hans-Joachim
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Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep. 2016 Dec 9;36(6)
Honarpisheh, Mohsen; Desai, Jyaysi; Marschner, Julian A.; Weidenbusch, Marc; Lech, Maciej; Vielhauer, Volker; Anders, Hans-Joachim & Mulay, Shrikant R.
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The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation? Mediators Inflamm. 2016;2016:2856213
Kulkarni, Onkar P.; Lichtnekert, Julia; Anders, Hans-Joachim & Mulay, Shrikant R.
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Evolutionary trade-offs in kidney injury and repair. Histol Histopathol 2017, May 8; 11900
Lei Y, Anders HJ
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Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury. Biosci Rep. 2017 Dec 22;37(6)
Weidenbusch, Marc; Rodler, Severin; Song, Shangqing; Romoli, Simone; Marschner, Julian A.; Kraft, Franziska; Holderied, Alexander; Kumar, Santosh; Mulay, Shrikant R.; Honarpisheh, Mohsen; Kumar Devarapu, Satish; Lech, Maciej & Anders, Hans-Joachim
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Thrombospondin immune regulation and the kidney. Nephrol Dial Transplant. 2017 Jan 14
Ponticelli, Claudio & Anders, Hans-Joachim
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Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury. Nat Commun. 2018 Apr 9;9(1):1344
Lazzeri, Elena; Angelotti, Maria Lucia; Peired, Anna; Conte, Carolina; Marschner, Julian A.; Maggi, Laura; Mazzinghi, Benedetta; Lombardi, Duccio; Melica, Maria Elena; Nardi, Sara; Ronconi, Elisa; Sisti, Alessandro; Antonelli, Giulia; Becherucci, Francesca; De Chiara, Letizia; Guevara, Ricardo Romero; Burger, Alexa; Schaefer, Beat; Annunziato, Francesco; ... & Romagnani, Paola
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IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis. Physiol Rep. 2018
Weidenbusch, Marc; Song, Shangqing; Iwakura, Takamasa; Shi, Chongxu; Rodler, Severin; Kobold, Sebastian; Mulay, Shrikant R.; Honarpisheh, Mohsen M. & Anders, Hans-Joachim
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Necroptosis in Acute Kidney Injury. Nephron. 2018;139(4):342-348
Anders, Hans-Joachim
