Role of TPC2 in cellular signaling networks (P06)

• Subject Area: Pharmacology
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

Two pore channels (TPCs) are endo-lysosomal cation channels which form a subgroup within the superfamily of TRP channels. In aim 1, properties of these channels will be characterized using endo-lysosomal single channel recordings. These experiments will be performed in HEK293 cells, in hepatocytes, cardiac myocytes and hippocampal neurons. In aim 2 the role of TPC2 in atherosclerosis will be analyzed in the ApoE-/- background in mice globally lacking TPC2 channels (TPC2-/-ApoE-/-), and mice with cell type specific and inducible deletion of TPC2 in macrophages, endothelial- or smooth muscle-cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Christian Wahl-Schott