The trp zoo: a combinatorial genetic approach to visualize and manipulate TRP-expressing cells (Z02)

• Subject Area: Medicine
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

The platform project will continue to I) develop and generate TRP-Cre driver mouse strains to visualize and manipulate primary TRP-expressing cells, II) systematically profile TRP-expression throughout the entire body of juvenile and adult TRP-Cre/floxed reporter mice. The results obtained in II) will be made available to the consortium in online TRP atlases in 2D and 3D (based on iDISCO whole organ clearing followed by lightsheet imaging) to provide TRP expression profiles in all anatomical regions of interest for the individual projects. Z02 will continue to III) support preparative sorting of TRP-Cre/floxed reporter cells, IV) develop and generate conditional trp alleles and V) serve as a repository of mouse lines.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Ulrich Boehm; Professor Dr. Veit Flockerzi, until 6/2022